Surfaces functionalized with hierarchical polymer brushes and their biomedical applications

Yang, Ran; Yin, Jinghua; Yan, Shuai; Luan, Shifang

doi:10.1360/ssc-2019-0159

“…This approach is becoming more practical as the copolymer synthesis technology advances. Surface-attached copolymer brushes can be achieved by using either “grafting from” or “grafting to” methods [ 177 ]. It is even possible to control the chemical sequence of the target copolymer at the resolution of single monomer [ 178 , 179 , 180 ].…”

Section: Applicationsmentioning

confidence: 99%

Theoretical Modeling of Chemical Equilibrium in Weak Polyelectrolyte Layers on Curved Nanosystems

Solveyra

¹

,

Nap

²

,

Huang

³

et al. 2020

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Surface functionalization with end-tethered weak polyelectrolytes (PE) is a versatile way to modify and control surface properties, given their ability to alter their degree of charge depending on external cues like pH and salt concentration. Weak PEs find usage in a wide range of applications, from colloidal stabilization, lubrication, adhesion, wetting to biomedical applications such as drug delivery and theranostics applications. They are also ubiquitous in many biological systems. Here, we present an overview of some of the main theoretical methods that we consider key in the field of weak PE at interfaces. Several applications involving engineered nanoparticles, synthetic and biological nanopores, as well as biological macromolecules are discussed to illustrate the salient features of systems involving weak PE near an interface or under (nano)confinement. The key feature is that by confining weak PEs near an interface the degree of charge is different from what would be expected in solution. This is the result of the strong coupling between structural organization of weak PE and its chemical state. The responsiveness of engineered and biological nanomaterials comprising weak PE combined with an adequate level of modeling can provide the keys to a rational design of smart nanosystems.

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Cobalt‐Catalyzed Facial‐Selective Hydroalkylation of Cyclopropenes

Zhang

¹

,

Li

²

,

Xu

³

et al. 2023

Angewandte Chemie

2

0

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Cyclopropene hydrofunctionalization has been a promising strategy for accessing multi-substituted cyclopropanes; however, cyclopropene hydroalkylation remains underdeveloped. Herein, we report a low-valent CoH-catalyzed facial-selective cyclopropene hydroalkylation to access multi-substituted cyclopropanes. This reaction exhibits a broad substrate scope of alkyl halides and cyclopropenes and tolerates many functional groups. Moderate-to-good facial-selectivity is obtained without any directing groups. Mechanism studies provide evidence that alkyl radicals are generated from alkyl halides and irreversible CoH insertion is responsible for the facial-selectivity. Our preliminary exploration demonstrates that asymmetric cyclopropene hydroalkylation can be realized without conspicuous auxiliary groups.

show abstract

Cobalt‐Catalyzed Facial‐Selective Hydroalkylation of Cyclopropenes

Zhang

¹

,

Li

²

,

Xu

³

et al. 2023

View full text Add to dashboard Cite

Cyclopropene hydrofunctionalization has been a promising strategy for accessing multi-substituted cyclopropanes; however, cyclopropene hydroalkylation remains underdeveloped. Herein, we report a low-valent CoH-catalyzed facial-selective cyclopropene hydroalkylation to access multi-substituted cyclopropanes. This reaction exhibits a broad substrate scope of alkyl halides and cyclopropenes and tolerates many functional groups. Moderate-to-good facial-selectivity is obtained without any directing groups. Mechanism studies provide evidence that alkyl radicals are generated from alkyl halides and irreversible CoH insertion is responsible for the facial-selectivity. Our preliminary exploration demonstrates that asymmetric cyclopropene hydroalkylation can be realized without conspicuous auxiliary groups.

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Surfaces functionalized with hierarchical polymer brushes and their biomedical applications

Cited by 5 publications

References 34 publications

Theoretical Modeling of Chemical Equilibrium in Weak Polyelectrolyte Layers on Curved Nanosystems

Theoretical Modeling of Chemical Equilibrium in Weak Polyelectrolyte Layers on Curved Nanosystems

Cobalt‐Catalyzed Facial‐Selective Hydroalkylation of Cyclopropenes

Cobalt‐Catalyzed Facial‐Selective Hydroalkylation of Cyclopropenes

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