Surfactant alterations following donation after cardiac death donor lungs

İnci, İlhan; Arni, Stephan; Acevedo, Christa; Jungraithmayr, Wolfgang; Inci, Demet; Vogt, Peter R.; Weder, Walter

doi:10.1111/j.1432-2277.2010.01154.x

Cited by 13 publications

(16 citation statements)

References 26 publications

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“…This was proven by significantly different adsorption and surface tension in DCD groups compared with heart-beating donor (HBD) group (49).…”

Section: Proof Of Concept and Experimental Backgroundmentioning

confidence: 97%

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Donors after cardiocirculatory death and lung transplantation

İnci

2017

J. Thorac. Dis.

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Abstract:The number of patients actively awaiting lung transplantation (LTx) is more than the number of suitable donor lungs. The percentage of lung retrieval rate is lower when compared to other solid organs.The use of lungs from donation after cardiocirculatory death (DCD) donors is one of the options to avoid organ shortage in LTx. After extensive experimental research, clinical application of DCD donation is becoming wider. The results from most of the centers show at least equal survival rate compared to donors from brain death. This review paper will summarize experimental background and clinical experience from DCD donors.

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“…This was proven by significantly different adsorption and surface tension in DCD groups compared with heart-beating donor (HBD) group (49).…”

Section: Proof Of Concept and Experimental Backgroundmentioning

confidence: 97%

“…To assess the surfactant alterations in DCD donor lungs (49) we showed that surfactant function decreases with increased WITs. This was proven by significantly different adsorption and surface tension in DCD groups compared with heart-beating donor (HBD) group (49).…”

Section: Proof Of Concept and Experimental Backgroundmentioning

confidence: 99%

Donors after cardiocirculatory death and lung transplantation

İnci

2017

J. Thorac. Dis.

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“…Inhaled nitric oxide and beta-adrenergic drugs were used in different studies. Another utilization of inhalation treatments is the one concerning surfactant (4,30). Anti-inflammatory drugs, antiapoptotic drugs, antibiotics, and immunosuppressants are added to the perfusate for treatment purposes.…”

Section: Examples For Study Methodsmentioning

confidence: 99%

“…For this procedure, 5 mL/ kg betaine HCL/pepsin was bronchoscopically instilled (24). Another application of EVLP is to assess organs of NHBD (30,31). This is why, death before harvesting should be initiated in the experimental setup.…”

Section: Injurymentioning

confidence: 99%

Ex-vivo Lung Perfusion and Its Role in Experimental Studies

Cosgun¹,

Dabak²,

Şenbaklavacı³

2017

Eurasian J Pulmonol

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To date, lung transplantation is an accepted and a preferred treatment modality for end-stage lung diseases (1-3). But ischemia reperfusion--related injury, allograft rejection, bronchiolitis obliterans, and chronic graft rejection are still important and detrimental problems in lung transplant medicine (2). The gap between the limited number of donor organs and the increase in the number of patients on the waiting list is increasing rapidly. The acceptance of lung donors is still 20%-30% so far. The scarcity of appropriate organs leads to improper utilization of marginal donors. One of the solutions to increase the number of donor organs is the meticulous evaluation of donor organs after cardiac death (2-4). This is why a method called ex-vivo lung perfusion (EVLP) was developed. The usefulness of EVLP on lung transplantation is firstly because this model makes it possible to evaluate the lung perfusion and functions of the body in the pre transplant period in marginal organs. By this method, we can make the right decision to implant. Second area of utilization is by preserving the graft after harvesting over long time intervals. Third area provides a platform for the development of additional therapies especially decreasing ischemia reperfusion (IRI). In this review, we aimed to provide the usage of EVLP on the development of treatment strategies in experimental studies and share our experiences with colleagues in the related field (5). General Perspective of Organ Culture SystemsThe experimental sciences have routinely used in-vivo and in-vitro models for stimulation of physiology and diseases. As a result of integration of physics and chemistry into in-vitro and in-vivo biomedicine, study on cell cultures and analyzing them at the molecular level became possible. The aim of ex-vivo experimental studies of organs is to create a system to stimulate human pathophysiology. Sys- Review Ex-vivo Lung Perfusion and Its Role in Experimental StudiesTuğba Coşgun AbstractLung transplantation is an accepted treatment modality for end-stage lung diseases. However, the donor pool is not getting larger in comparison to the number of patients on the waiting list. Of the patients on the waiting list for lung transplant, more than a quarter dies while waiting. Utilization of marginal donors became an issue, and ex-vivo lung perfusion (EVLP) was started to be performed to solve this problem. Besides that, success in lung transplantation has not reached a satisfactory level for various reasons including ischemia reperfusion injury. Treatment options against these reasons that cause low success of lung transplantations are being investigated by many centers. Nowadays, EVLP that was initially developed to re-evaluate marginal donors has become a method for studies in experimental models. In our article, we want to review EVLP models in experimental studies.

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“…Warm ischemia is the ischemia of cells and tissues under normothermic conditions. It leads to endothelial dysfunction and to alveolar type II cell dysfunction resulting in pulmonary edema and graft dysfunction during reperfusion [6][7][8][9]. There is experimental and clinical evidence that 1 h of WI does not compromise the function of the pulmonary graft [10].…”

Section: Introductionmentioning

confidence: 99%

In situ lung perfusion is a valuable tool to assess lungs from donation after circulatory death donors category I-II

et al. 2013

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SummaryDonations after circulatory death (DCD) lung grafts are an alternative to extend the donor pool in lung transplantation. This study investigates the use of an in situ lung perfusion system (ISLP) in the donor to evaluate category I-II lungs. Pigs were sacrificed by ventricular fibrillation. All animals underwent 20 min of cardiopulmonary resuscitation and 5 min hands-off period after which heparin was administered. In group [WI-1], this was followed by 1 h of warm ischemia (WI) and 2 h of topical cooling (TC). In group [WI-2], 2 h of WI was followed by 1 h of TC. In group [WI-0], there was a minimal period of WI and no TC. In all three groups, the lungs were then evaluated during 60 min with ISLP. A high W/D weight ratio was correlated with a lower compliance, higher lactate production, and a higher PaCO 2 . ISLP is an effective way to assess the quality of lungs from category I-II DCD donors.

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Surfactant alterations following donation after cardiac death donor lungs

Cited by 13 publications

References 26 publications

Donors after cardiocirculatory death and lung transplantation

Donors after cardiocirculatory death and lung transplantation

Ex-vivo Lung Perfusion and Its Role in Experimental Studies

In situ lung perfusion is a valuable tool to assess lungs from donation after circulatory death donors category I-II

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