2022
DOI: 10.1002/cbic.202200568
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Surfactant‐Assisted Purification of Hydrophobic DNA Nanostructures

Abstract: Purification of functional DNA nanostructures is an essential step in achieving intended functions because misfolded structures and the remaining free DNA strands in a solution can interact and affect their behavior. However, due to hydrophobicity-mediated aggregation, it is difficult to purify DNA nanostructures modified with hydrophobic molecules by conventional methods. Herein, we report the purification of cholesterol-modified DNA nanostructures by using a novel surfactant-assisted gel extraction. The addi… Show more

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“…To avoid this issue, surfactant was often mixed with the hydrophobic nanopores. Expanding this approach, a surfactant‐assisted purification method for cholesterol‐modified nanopores was developed [26] . Adding sodium cholate, an anionic surfactant, to the sample solution before the nanopore folding prevented aggregation, which allowed purification of the structure by gel extraction.…”
Section: Function Of Transmembrane Dna Nanostructuresmentioning
confidence: 99%
“…To avoid this issue, surfactant was often mixed with the hydrophobic nanopores. Expanding this approach, a surfactant‐assisted purification method for cholesterol‐modified nanopores was developed [26] . Adding sodium cholate, an anionic surfactant, to the sample solution before the nanopore folding prevented aggregation, which allowed purification of the structure by gel extraction.…”
Section: Function Of Transmembrane Dna Nanostructuresmentioning
confidence: 99%