Surfactant Effect on the Physicochemical Characteristics of Solid Lipid Nanoparticles Based on Pillar[5]arenes

Nazarova, A. A.; Yakimova, Luidmila S.; Filimonova, Darya; Stoikov, Ivan I.

doi:10.3390/ijms23020779

Cited by 10 publications

(4 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previously, our research group optimized acylation conditions with succinic anhydride of monosubstituted pillar[5]arenes containing N -propylamide and N -(aminobutyl)amide fragments [ 21 ]. Pillar[5]arene 1 containing one diethylenetriamine fragment, which has primary and secondary amino groups, was chosen as a starting amine for interaction with succinic anhydride.…”

Section: Resultsmentioning

confidence: 99%

“…A number of works have proposed amphiphilic molecules, e.g., calix[n]arenes and cyclodextrins, as lipid analogues [ 14 , 15 , 16 , 17 , 18 ]. The use of a promising class of macrocycles, pillar[5]arenes, in the synthesis of SLN was shown for the first time in our research group [ 19 , 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

“…The presented work is ongoing studies of the monosubstituted pillar[5]arene as a building block for nanoparticles [ 19 , 20 , 21 ]. We assumed that minor changes in the substituent structure of macrocycle can dramatically change the stability and shape of the SLN.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Solid Lipid Nanoparticles Based on Monosubstituted Pillar[5]arenes: Chemoselective Synthesis of Macrocycles and Their Supramolecular Self-Assembly

et al. 2022

Self Cite

View full text Add to dashboard Cite

Novel monosubstituted pillar[5]arenes with one or two terminal carboxyl groups were synthesized by the reaction of succinic anhydride with pillar[5]arene derivative containing a diethylenetriamine function. The ability for non-covalent self-assembly in chloroform, dimethyl sulfoxide, as well as in tetrahydrofuran-water system was studied. The ability of the synthesized macrocycles to form different types of associates depending on the substituent nature was established. The formation of stable particles with average diameter of 192 nm in chloroform and of 439 nm in DMSO was shown for pillar[5]arene containing two carboxyl fragments. Solid lipid nanoparticles (SLN) based on monosubstituted pillar[5]arenes were synthesized by nanoprecipitation in THF-water system. Minor changes in the structure of the macrocycle substituent can dramatically influence the stability and shape of SLN (spherical and rod-like structures) accordingly to DLS and TEM. The presence of two carboxyl groups in the macrocycle substituent leads to the formation of stable spherical SLN with an average hydrodynamic diameter of 364–454 nm. Rod-like structures are formed by pillar[5]arene containing one carboxyl fragment, which diameter is about of 50–80 nm and length of 700–1000 nm. The synthesized stable SLN open up great prospects for their use as drug storage systems.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Solid Lipid Nanoparticles Based on Monosubstituted Pillar[5]arenes: Chemoselective Synthesis of Macrocycles and Their Supramolecular Self-Assembly

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…Moreover, the choice of lipid and surfactant components can affect the stability and integrity of the VVS during storage, transportation, and administration [ 139 ]. Lipid and surfactant molecules can undergo oxidation, hydrolysis, or aggregation, ultimately leading to changes in the physical and chemical properties of the nanocarrier and the contained drug [ 140 ]. These changes can affect the release profile, biodistribution, and efficacy of the drug, thus limiting its bioavailability [ 141 ].…”

Section: Challenges and Limitationsmentioning

confidence: 99%

Synergistic vesicle-vector systems for targeted delivery

Marquez,

Oh,

Ahn

et al. 2024

J Nanobiotechnol

View full text Add to dashboard Cite

With the immense progress in drug delivery systems (DDS) and the rise of nanotechnology, challenges such as target specificity remain. The vesicle-vector system (VVS) is a delivery system that uses lipid-based vesicles as vectors for a targeted drug delivery. When modified with target-probing materials, these vesicles become powerful vectors for drug delivery with high target specificity. In this review, we discuss three general types of VVS based on different modification strategies: (1) vesicle-probes; (2) vesicle-vesicles; and (3) genetically engineered vesicles. The synthesis of each VVS type and their corresponding properties that are advantageous for targeted drug delivery, are also highlighted. The applications, challenges, and limitations of VVS are briefly examined. Finally, we share a number of insights and perspectives regarding the future of VVS as a targeted drug delivery system at the nanoscale. Graphical Abstract

show abstract

Solid lipid nanocarriers for drug delivery: design innovations and characterization strategies—a comprehensive review

Bukke,

Venkatesh,

Bandenahalli Rajanna

et al. 2024

Discov Appl Sci

View full text Add to dashboard Cite

Lipid-based colloidal carriers, particularly Solid Lipid Nanoparticles (SLNs), offer a versatile platform for formulating hydrophobic drugs, presenting significant pharmaceutical implications across diverse fields. This paper explores methodologies utilized in SLN production, ranging from high-pressure homogenization to microemulsion techniques, with each method influencing the characteristics and efficacy of the resultant nanoparticles. Various administration routes for SLNs exist, leveraging the lipid matrix's protective properties to shield encapsulated drugs, thus minimizing degradation and enhancing therapeutic efficacy. Furthermore, SLNs exhibit sustained release properties, facilitating prolonged drug delivery and reducing the need for frequent dosing. Their small size and high surface area contribute to improved drug dissolution, enhanced bioavailability, and extended retention within the body. The existence of multiple patents underscores the substantial research conducted in the domain of SLNs, with numerous commercial formulations available globally. In conclusion, this work highlights the intricate nature of SLNs and their pivotal role in advancing drug delivery techniques. Ongoing efforts are directed toward overcoming challenges and exploring novel therapeutic avenues, highlighting the dynamic and evolving landscape of SLN research and application.

show abstract

Surfactant Effect on the Physicochemical Characteristics of Solid Lipid Nanoparticles Based on Pillar[5]arenes

Cited by 10 publications

References 50 publications

Solid Lipid Nanoparticles Based on Monosubstituted Pillar[5]arenes: Chemoselective Synthesis of Macrocycles and Their Supramolecular Self-Assembly

Solid Lipid Nanoparticles Based on Monosubstituted Pillar[5]arenes: Chemoselective Synthesis of Macrocycles and Their Supramolecular Self-Assembly

Synergistic vesicle-vector systems for targeted delivery

Solid lipid nanocarriers for drug delivery: design innovations and characterization strategies—a comprehensive review

Contact Info

Product

Resources

About