Surfactant for a Patient with Refractory Pyopneumothorax and Acute Respiratory Distress Syndrome Due to Pneumococcal Necrotizing Pneumonia Complicated by a Bronchopleural Fistula

Öztürk, Zeynelabidin; Küçükkuray, Merve Duman; Özdem, Suna; Çınar, Hasibe Gökçe; Aytekin, Caner; Çağlar, Özgür

doi:10.1089/ped.2022.0112

Cited by 2 publications

(1 citation statement)

References 12 publications

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“…NP is characterized by necrosis and liquification of lung parenchyma and loss of the normal pulmonary parenchymal architecture [ 7 ]. Moreover, NP is associated with a higher risk of complications such as parapneumonic effusion, pleural empyema, pyothorax, pneumothorax, pyopneumothorax, septic shock, respiratory failure, hemolytic uremic syndrome (HUS) and bronchopleural fistula (BPF) [ 8 , 9 ]. In view of the severity of NP and heavy burden of hospitalization especially in developing countries, early prediction and management are essential for good recovery and prognosis.…”

Section: Introductionmentioning

confidence: 99%

Necrotizing Pneumonia in Children: Early Recognition and Management

Chen

Wang

et al. 2023

JCM

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Necrotizing pneumonia (NP) is an uncommon complicated pneumonia with an increasing incidence. Early recognition and timely management can bring excellent outcomes. The diagnosis of NP depends on chest computed tomography, which has radiation damage and may miss the optimal treatment time. The present review aimed to elaborate on the reported predictors for NP. The possible pathogenesis of Streptococcus pneumoniae, Staphylococcus aureus, Mycoplasma pneumoniae and coinfection, clinical manifestations and management were also discussed. Although there is still a long way for these predictors to be used in clinical, it is necessary to investigate early predictors for NP in children.

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Section: Introductionmentioning

confidence: 99%

Necrotizing Pneumonia in Children: Early Recognition and Management

Chen

Wang

et al. 2023

JCM

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Role of systemic immune-inflammatory index and systemic inflammatory response index in predicting the diagnosis of necrotizing pneumonia in children

Elmeazawy,

Ayoub,

Morad

et al. 2024

BMC Pediatr

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Background Necrotizing pneumonia (NP) is a rare serious complication of community-acquired pneumonia (CAP) in children, which is characterized by a protracted course of the disease and a prolonged hospital stay. This study aimed to assess the role of systemic immune-inflammatory index and systemic inflammatory response index in predicting early lung necrotization in children with CAP. Methods This study included all children hospitalized in Pediatric Pulmonology Unit, Tanta University, Egypt, with CAP between the ages of two months and 18 years. Systemic inflammatory indices, including the neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), monocyte/lymphocyte ratio (MLR), systemic immune-inflammatory index (SII), and systemic inflammation response index (SIRI), were calculated on patients’ admission. Results The study involved a total of 228 children, 42 patients had NP, 46 patients had parapneumonic effusion, and 140 patients had non-complicated CAP. Patients with NP were substantially younger (p = 0.002), stayed in the hospital longer (p < 0.001), had a longer duration of symptoms before hospital admission (p < 0.001), and had fever for a longer duration than those in the other groups (p < 0.001). Regarding the inflammatory ratios, patients with NP had significantly higher MLR, PLR, SII, and SIRI than those in the other groups (p = 0.020, p = 0.007, p = 0.001, p = 0.037, respectively). ROC curve analysis showed that the combined SII + SIRI + D-dimer showed the highest AUC with a good specificity in predicting the diagnosis of NP. Conclusions SII, SIRI, and D-dimer may be beneficial biomarkers for predicting the occurrence of NP in children when performed on patients’ admission. In addition, it was found for the first time that combined SII + SIRI + D-dimer had a good sensitivity and specificity in the diagnosis of NP.

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Surfactant for a Patient with Refractory Pyopneumothorax and Acute Respiratory Distress Syndrome Due to Pneumococcal Necrotizing Pneumonia Complicated by a Bronchopleural Fistula

Cited by 2 publications

References 12 publications

Necrotizing Pneumonia in Children: Early Recognition and Management

Necrotizing Pneumonia in Children: Early Recognition and Management

Role of systemic immune-inflammatory index and systemic inflammatory response index in predicting the diagnosis of necrotizing pneumonia in children

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