2017
DOI: 10.1159/000458466
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Surfactant for Respiratory Distress Syndrome: New Ideas on a Familiar Drug with Innovative Applications

Abstract: In the last 4 decades, advances in neonatology have led to a significant increase in the survival of preterm infants. One of the biggest advances was the introduction of surfactant replacement therapy for the treatment of respiratory distress syndrome. This is the main cause of respiratory insufficiency in preterm infants and is one of the major causes of perinatal morbidity and mortality. Surfactant replacement therapy is already a well-investigated and established therapy in neonatology. However, surfactant … Show more

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Cited by 51 publications
(28 citation statements)
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“…The authors presumed that the distribution of the surfactant caused these differences. Using animal experiments, Niemarkt reported decreased surfactant distribution to the right upper lobe in the LISA method compared with the intubation method [18]. Surfactant distribution, which is affected by the volume of the administered surfactant, rate of installation, the position of the infant, and underline the status of the lung of the patient, is an essential factor of surfactant administration [19].…”
Section: Discussionmentioning
confidence: 99%
“…The authors presumed that the distribution of the surfactant caused these differences. Using animal experiments, Niemarkt reported decreased surfactant distribution to the right upper lobe in the LISA method compared with the intubation method [18]. Surfactant distribution, which is affected by the volume of the administered surfactant, rate of installation, the position of the infant, and underline the status of the lung of the patient, is an essential factor of surfactant administration [19].…”
Section: Discussionmentioning
confidence: 99%
“…The LISA method via thin catheter is widely adapted in Europe [29] and is a recommended method of care according to the latest consensus guidelines [9,12,30]. However, there is still large variability in the application of this technique regarding patient population that may bene t from this approach; the catheter type, the adequate dose and type of surfactant; the use of premedication; and the need of pharmacologic sedation during the procedure [31].…”
Section: Discussionmentioning
confidence: 99%
“…We appreciated the survey respondents' comments about the use of MIST or LISA prior intubation if patient fails on CPAP support. 18,29,30 We received two comments by the survey responders that they would use a threshold FiO 2 of 30% while on humidified high flow nasal cannula (HHFNC) therapy. Recent surveys have found extensive use of HHFNC in special care nurseries in many parts of the world.…”
Section: Nomentioning
confidence: 99%