Surfactant lipids containing aromatic units produce vesicular membranes with high thermal stability

Bhattacharya, Santanu; Subramanian, Marappan; Hiremath, Uma S.

doi:10.1016/0009-3084(95)02494-4

Cited by 29 publications

(15 citation statements)

References 28 publications

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“…Briefly, 4-n-alkyloxybenzoic acid was first synthesized from 4-hydroxybenzoic acid and 1-bromoalkane and purified according to the reported procedure [40]. The coupling of L-alanine, DL-alanine, or L-lactic acid ester and 4-n-alkyloxybenzoic acid was made via the formation of NHS ester in the presence of DCC.…”

Section: Synthesismentioning

confidence: 99%

Birefringent physical gels of N-(4-n-alkyloxybenzoyl)-l-alanine amphiphiles in organic solvents: The role of hydrogen-bonding

Patra

Pal

Dey

2010

Journal of Colloid and Interface Science

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Section: Synthesismentioning

confidence: 99%

Birefringent physical gels of N-(4-n-alkyloxybenzoyl)-l-alanine amphiphiles in organic solvents: The role of hydrogen-bonding

Patra

Pal

Dey

2010

Journal of Colloid and Interface Science

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“…45 Toward this end Bhattacharya et al developed cationic lipids containing aromatic units which produced vesicular membranes with high thermal stability. 46 These authors also synthesized novel phosphatidylcholine lipids with fatty acid chains bearing aromatic units at various lengths. This afforded generation of oxidatively stable fluid membranes from unsaturated phospholipids.…”

Section: Chemistry Of Cationic Lipidsmentioning

confidence: 99%

Advances in gene delivery through molecular design of cationic lipids

2009

Self Cite

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This feature article describes the recent developments in the design of cationic lipids and their applications in gene delivery. Various structure-activity investigations explaining the variations in gene transfection efficacies with respect to different molecular structures of the cationic lipids have been discussed. Gene transfer abilities are presented in relation to aggregation properties of different aqueous formulations such as cationic liposomes and surfactant aggregates from various amphiphiles and cationic lipids, as a function of their hydrophobic parts, linkers and head groups.

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“…All cationic lipids (CLs) bear a dimethylammonium bromide headgroup (DAB) as the DNA-binding moiety yet different hydrophobic parts. [2728] Importantly, the miscibility of the CLs with DMPC was assessed by scanning liposomes composed of CL-DMPC mixtures with molar ratios from 0 to 1. The DSC profiles manifested that maximum miscibility was achieved for low CL to DMPC molar ratios (≤0.15).…”

Section: Dna–membrane Interactionsmentioning

confidence: 99%

Nucleic acid-lipid membrane interactions studied by DSC

Giatrellis

Nounesis²

2011

J Pharm Bioall Sci

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The interactions of nucleic acids with lipid membranes are of great importance for biological mechanisms as well as for biotechnological applications in gene delivery and drug carriers. The optimization of liposomal vectors for clinical use is absolutely dependent upon the formation mechanisms, the morphology, and the molecular organization of the lipoplexes, that is, the complexes of lipid membranes with DNA. Differential scanning calorimetry (DSC) has emerged as an efficient and relatively easy-to-operate experimental technique that can straightforwardly provide data related to the thermodynamics and the kinetics of the DNA—lipid complexation and especially to the lipid organization and phase transitions within the membrane. In this review, we summarize DSC studies considering nucleic acid—membrane systems, accentuating DSC capabilities, and data analysis. Published work involving cationic, anionic, and zwitterionic lipids as well as lipid mixtures interacting with RNA and DNA of different sizes and conformations are included. It is shown that despite limitations, issues such as DNA- or RNA-induced phase separation and microdomain lipid segregation, liposomal aggregation and fusion, alterations of the lipid long-range molecular order, as well as membrane-induced structural changes of the nucleic acids can be efficiently treated by systematic high-sensitivity DSC studies.

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Surfactant lipids containing aromatic units produce vesicular membranes with high thermal stability

Cited by 29 publications

References 28 publications

Birefringent physical gels of N-(4-n-alkyloxybenzoyl)-l-alanine amphiphiles in organic solvents: The role of hydrogen-bonding

Birefringent physical gels of N-(4-n-alkyloxybenzoyl)-l-alanine amphiphiles in organic solvents: The role of hydrogen-bonding

Advances in gene delivery through molecular design of cationic lipids

Nucleic acid-lipid membrane interactions studied by DSC

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