Surfactant Protein D in <i>Helicobacter Pylori</i> Infection

Murray, E; Walker, M M; P, Eggleton; Ferris, John A.; Moran, Anthony P.; Mac, SDonald; Knapp, S.; Karim, N. Q.; Worku, M; Strong, Peter; Reid, K. B. M.; Thursz, Mark

doi:10.1042/cs098002pb

Cited by 1 publication

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“…In the gastrointestinal tract, DMBT1 was found to be secreted from the apical membrane of epithelia onto the mucosal surface, where binding of invading pathogens such as S. mutans and H. pylori [15], and host defense components such as SP‐D [45] and sIgA [35], could take place. All these ligands are involved in local inflammation in gastric mucosa [46]. DMBT1 homologs have also been identified as putative receptor for trefoil factors, the peptides known to play a major role in the acute phase protection of mucosa surface upon tissue injury [47].…”

Section: Dmbt1 a Linkage Between Mucosal Defense And Epithelial Regementioning

confidence: 99%

DMBT1, a regulator of mucosal homeostasis through the linking of mucosal defense and regeneration?

Kang

Reid

2003

FEBS Letters

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DMBT1 (deleted in malignant brain tumor 1), which encodes a large scavenger receptor cysteine rich (SRCR) B protein, has been proposed to be a tumor suppressor gene, due to the high frequency of its homozygous deletion and the lack of expression in a variety of cancers. However, studies on its physiological functions and its relationship with tumorigenesis are still at an initial stage. Two mucosal defense-related molecules, gp-340 and salivary agglutinin, have been identi¢ed to be alternatively spliced products of DMBT1, which suggests that DMBT1 is a pattern recognition receptor in innate immunity. Meanwhile, results from immunohistochemical staining and studies at the cellular level, began to associate DMBT1 with a proliferation to di¡erentiation switching process in gastrointestinal epithelial cells. Together with its up-regulation in in£ammation, these ¢ndings suggest that DMBT1 might be a local regulator of homeostasis, possibly through linking mucosal in£ammation to the modulation of epithelial regeneration, and whose abnormality is a frequent cause of malignancy.

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Section: Dmbt1 a Linkage Between Mucosal Defense And Epithelial Regementioning

confidence: 99%