Surfactant protein (SP) B associations and interactions with SP‐A in white and black subjects with respiratory distress syndrome

Floros, Joanna; Fan, Ruzong; DiAngelo, Susan; Guo, Xiaoxuan; Wert, Jr Jj; Luo, Jiang

doi:10.1046/j.1442-200x.2001.01474.x

Cited by 68 publications

(82 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Regarding the protection against the development of the disease, it was evident both in the heterozygous C/T and homozygous T/T genotype. The authors suggested that the genotype T/T seem to increase the protection in relation to the disease, as was demonstrated with the black patients with RDS by Floros et al 56 In a study conducted in Finland, the genotype C/C of the polymorphism C/T 1580 seemed to constitute both a risk factor for the alleles of SP-A for susceptibility to RDS and a protective factor for the allele 6A3. 60 Guo et al showed that the allele C seemed to be associated with a high risk of chronic obstructive pulmonary disease.…”

Section: Genetic Factors Of Respiratory Distress Syndromementioning

confidence: 78%

“…36 In 2001 Floros et al conducted a case-control study with preterm newborns with and without RDS. 56 The authors concluded that the genotype A/G of the polymorphism A/ G 9306 seems to be a susceptibility factor for RDS in individuals with gestational age greater than or equal to 33 weeks. The presence of specific alleles of SP-A and SP-B in the same individual resulted in a considerable change of the values of P or odds ratio, when compared to the values obtained with each genotype separately.…”

Section: Genetic Factors Of Respiratory Distress Syndromementioning

confidence: 98%

“…Floros et al, in 2001, 56 genotyped individuals with and without RDS for variants of intron 4 and for 4 polymorphisms of SP-B: AC-18, AC-1013, CT-1580, and AG-9306. The objective of these authors was to study casecontrol associations in black newborns and white newborns.…”

Section: Genetic Factors Of Respiratory Distress Syndromementioning

confidence: 99%

“…In black individuals, however, the SP-A1, 6A3 protector genotype, in the presence of genotype SP-B 1580 (T/T), showed an increase protection against RDS, especially in individuals with advanced gestational ages. 56 The polymorphism 1580 (C/T), present at the end of exon 4, on nucleotide 1580, affects the amino acid 131, altering the threonine amino acid (ACT) to isoleucine (ATT). Such an alteration eliminates a potential site of glycosylation and is associated with certain pulmonary pathologies.…”

Section: Genetic Factors Of Respiratory Distress Syndromementioning

confidence: 99%

“…No significant interaction was observed between either of the two loci and the alleles of SP-A. 56 In 2003, Liu et al conducted a study to evaluate the similarity of genetic markers among populations from 3 different ethnic groups (Caucasians, Blacks, and Hispanics), with the objective of observing whether people from different races or ethnic groups could be grouped in linkage analysis studies. The results showed that the allele and genotype frequencies could be different among diverse ethnic groups, especially among ethnic groups of different races.…”

Section: Genetic Factors Of Respiratory Distress Syndromementioning

confidence: 99%

See 4 more Smart Citations

The Importance of Surfactant on the Development of Neonatal Pulmonary Diseases

Lyra

Diniz

2007

Clinics

View full text Add to dashboard Cite

Section: Genetic Factors Of Respiratory Distress Syndromementioning

confidence: 78%

Section: Genetic Factors Of Respiratory Distress Syndromementioning

confidence: 98%

Section: Genetic Factors Of Respiratory Distress Syndromementioning

confidence: 99%

Section: Genetic Factors Of Respiratory Distress Syndromementioning

confidence: 99%

Section: Genetic Factors Of Respiratory Distress Syndromementioning

confidence: 99%

See 3 more Smart Citations

The Importance of Surfactant on the Development of Neonatal Pulmonary Diseases

Lyra

Diniz

2007

Clinics

View full text Add to dashboard Cite

Predictive index for adverse perinatal outcome in pregnancies complicated by fetal growth restriction

Powel

Zantow

Bialko

et al. 2023

Ultrasound in Obstet & Gyne

View full text Add to dashboard Cite

Objectives To develop and validate an index predictive of adverse perinatal outcome (APO) in pregnancies meeting the consensus‐based criteria for fetal growth restriction (FGR) endorsed by the International Society of Ultrasound in Obstetrics and Gynecology (ISUOG). Methods This was a retrospective analysis of consecutive singleton non‐anomalous gestations meeting the ISUOG‐endorsed criteria for FGR at a single tertiary care center from November 2010 to August 2020. The dataset was divided randomly into a development set (two‐thirds) and a validation set (one‐third). The primary composite APO comprised one or more of: perinatal demise, Grade III–IV intraventricular hemorrhage (IVH), periventricular leukomalacia (PVL), seizures, hypoxic ischemic encephalopathy (HIE), necrotizing enterocolitis (NEC), sepsis, bronchopulmonary dysplasia (BPD) and length of stay in the neonatal intensive care unit (NICU) > 7 days. Regression analysis incorporated clinical factors readily available at the time of FGR diagnosis. The sum of β coefficient‐based weights yielded an index score, the performance of which was assessed in the validation set. Score cut‐offs were selected to identify ‘high‐risk’ and ‘low‐risk’ ranges for which positive (PPV) and negative (NPV) predictive values and positive (LR+) and negative (LR–) likelihood ratios were calculated. Results Of the 875 consecutive pregnancies that met the criteria for FGR and were included in the study cohort, 405 (46%) were complicated by one or more components of the composite APO, including 54 (6%) perinatal deaths, 22 (3%) neonates with Grade III–IV IVH and/or PVL, nine (1%) with seizures and/or HIE, 91 (10%) with BPD, 57 (7%) with sepsis, 21 (2%) with NEC, and 361 (41%) who remained in the NICU > 7 days. In addition, 270 (31%) pregnancies were delivered by Cesarean section for non‐reassuring fetal status, 43 (5%) were admitted to the NICU for < 7 days, 79 (9%) had 5‐min Apgar score < 7, 125/631 (20%) had a cord gas pH ≤ 7.1 and 35/631 (6%) had a base excess ≥ 12 mmol/L. The predictive index we developed included seven factors available at the time of FGR diagnosis: hypertensive disorder of pregnancy (HDP) (+8 points), chronic hypertension without HDP (+4 points), gestational age ≤ 32 weeks (+5 points), absent or reversed end‐diastolic flow in the umbilical artery (+8 points), prepregnancy body mass index ≥ 35 kg/m2 (+3 points), isolated abdominal circumference < 3rd percentile (−4 points) and non‐Hispanic black race (−2 points). The bias‐corrected bootstrapped (1000 replicates) area under the receiver‐operating‐characteristics curve (AUC) of the predictive index for composite APO in the validation group was 0.88 (95% CI, 0.84–0.92), which was similar to that in the development group (AUC, 0.86 (95% CI, 0.82–0.89); P = 0.34). In the total cohort, 40% of pregnancies had a low‐risk index score (≤ 2), associated with a NPV of 85% (95% CI, 81–88%) and a LR– of 0.21 (95% CI, 0.16–0.27), and 23% had a high‐risk index score (≥ 10), associated with a PPV of 96% (95% CI, 93–98...

show abstract