Surfactant proteins A and D in pregnancy and parturition

Yadav, Ajit Kumar; Madan, Taruna; Bernal, Andrés López

doi:10.2741/e244

Cited by 11 publications

(6 citation statements)

References 47 publications

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“…SP-A and SP-D expression was subsequently observed in several extrapulmonary organs including kidney, salivary gland, prostate gland, pancreas, intestine, stomach and female reproductive tract 24–25, 27, 38–39 . Several studies demonstrated that both SP-A and SP-D proteins play roles not only in the respiratory system 13 , but also in the gastrointestinal tract 40 and the reproductive system 41 . Urinary tract system is exposed to various environmental factors including pathogens and requires multiple host defense mechanisms against environmental insults, including agents of the innate immunity such as SP-A and SP-D.…”

Section: Discussionmentioning

confidence: 99%

Innate immunity of surfactant proteins A and D in urinary tract infection with uropathogenic Escherichia coli

Ding

Zhang

et al. 2015

Innate Immun

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To investigate the effects of surfactant proteins A and D (SP-A, SP-D) in urinary tract infection (UTI), SP-A and SP-D double knockout (SP-A/D KO) and wild type (WT) C57BL/6 female mice were infected with uropathogenic Escherichia coli by intravesical inoculation. Compared with WT mice SP-A/D KO mice showed increased susceptibility to UTI as evidenced by higher bacterial CFU, more infiltrating neutrophils and severe pathological changes. Keratinocyte-derived chemokine increased in the kidney of WT mice but not in SP-A/D KO mice 24 h post-infection. Compared to control, level of IL-17 was elevated in the kidney of infected WT and SP-A/D KO mice and the level of IL-17 was higher in the infected SP-A/D KO mice than infected WT mice 24 and 48 h post-infection. Basal level of p38 MAPK phosphorylation in SP-A/D KO mice was higher compared to WT mice. Phosphorylated-p38 level was elevated in the kidney of WT mice post-infection but not in SP-A/D KO mice. Furthermore, in vitro growth of uropathogenic E. coli was inhibited by SP-A and SP-D. We conclude that SP-A and SP-D function as mediators of innate immunity by inhibiting bacterial growth and modulating renal inflammation in part by regulating p38 MAPK-related pathway in murine UTI.

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Section: Discussionmentioning

confidence: 99%

Innate immunity of surfactant proteins A and D in urinary tract infection with uropathogenic Escherichia coli

Ding

Zhang

et al. 2015

Innate Immun

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“…Quantitative real-time RT-PCR demonstrated expression of SP-A1 mRNA, which was 17.4-fold higher in patients delivering preterm with chorioamniotis. Several studies have also established that SP-A is an important marker that increases during the intricate signaling that mediates parturition (Breuiller-Fouche et al, 2010; Chaiworapongsa et al, 2008; Garcia-Verdugo et al, 2010; Leong et al, 2008; Salminen et al, 2008; Snegovskikh et al, 2011; Yadav et al, 2011). Most recently, statistically significant delay in the time to parturition was evident in SP-A and D doubly deficient mice (Montalbano et al, 2013).…”

Section: Review Of the Localization And Known Functions Of Extra-pmentioning

confidence: 99%

Structure, genetics and function of the pulmonary associated surfactant proteins A and D: The extra-pulmonary role of these C type lectins

Vieira

Kung

Bhatti

2017

Annals of Anatomy - Anatomischer Anzeiger

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The collectins family encompasses several collagenous Ca2+-dependent defense lectins that are described as pathogen recognition molecules. They play an important role in both adaptive and innate immunity. Surfactant protein A and D are two of these proteins which were initially discovered in association with surfactant in the pulmonary system. The structure, immune and inflammatory functions, and genetic variations have been well described in relation to their roles, function and pathophysiology in the pulmonary system. Subsequently, these proteins have been discovered in a wide range of other organs and organ systems. The role of these proteins outside the pulmonary system is currently an active area of research. This review intends to provide a current overview of the genetics, structure and extra-pulmonary functions of the surfactant collectin proteins.

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“…The role of SP-A in innate immunity is primarily mediated by its ability to bind several pathogens, enhance phagocytosis and chemotaxis of alveolar macrophages, induce proliferation of immune cells, and stimulate proinflammatory cytokine production, as well as to modulate the generation of reactive oxygen species (reviewed in (Phelps, 2001; Wright, 2005; Wang and Reid, 2007)). Furthermore, SP-A participates in several other functions that involve secretion of surfactant, signaling the initiation of parturition, as well as maintaining the structure of the extracellular form of surfactant tubular myelin (Williams et al, 1991; Condon et al, 2004; Wang et al, 2010; Snegovskikh et al, 2011; Yadav et al, 2011). Moreover, the expression and function of SP-A is not restricted to alveolar epithelial cells.…”

Section: Surfactant Proteinsmentioning

confidence: 99%

Genetic complexity of the human surfactant-associated proteins SP-A1 and SP-A2

Silveyra¹,

Floros²

2013

Gene

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Pulmonary surfactant protein A (SP-A) plays a key role in innate lung host defense, in surfactant-related functions, and in parturition. In the course of evolution, the genetic complexity of SP-A has increased, particularly in the regulatory regions (i.e. promoter, untranslated regions). Although most species have a single SP-A gene, two genes encode SP-A in humans and primates (SFTPA1and SFTPA2). This may account for the multiple functions attributed to human SP-A, as well as the regulatory complexity of its expression by a relatively diverse set of protein and non-protein cellular factors. The interplay between enhancer cis-acting DNA sequences and trans-acting proteins that recognize these DNA elements is essential for gene regulation, primarily at the transcription initiation level. Furthermore, regulation at the mRNA level is essential to ensure proper physiological levels of SP-A under different conditions. To date, numerous studies have shown significant complexity of the regulation of SP-A expression at different levels, including transcription, splicing, mRNA decay, and translation. A number of trans-acting factors have also been described to play a role in the control of SP-A expression. The aim of this report is to describe the genetic complexity of the SFTPA1 and SFTPA2 genes, as well as to review regulatory mechanisms that control SP-A expression in humans and other animal species.

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Surfactant proteins A and D in pregnancy and parturition

Cited by 11 publications

References 47 publications

Innate immunity of surfactant proteins A and D in urinary tract infection with uropathogenic Escherichia coli

Innate immunity of surfactant proteins A and D in urinary tract infection with uropathogenic Escherichia coli

Structure, genetics and function of the pulmonary associated surfactant proteins A and D: The extra-pulmonary role of these C type lectins

Genetic complexity of the human surfactant-associated proteins SP-A1 and SP-A2

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