Surfactant Replacement Therapy

Dekowski, Steven A.; Holtzman, Ronald B.

doi:10.1016/s0031-3955(05)70027-4

Cited by 17 publications

(2 citation statements)

References 129 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Since the pioneering efforts of Fujiwara and colleagues in the 1980s, 57 numerous clinical trials have demonstrated the efficacy of exogenous surfactant in improving the compliance of the lung, decreasing requirements for inspired oxygen, improving oxygenation, reducing the incidence of air-leak complications, and increasing survival. 58 Moreover, the pathologist can encounter hemorrhage with extravasations of erythrocytes in the interstitial space and alveoli, hyaline membranes, evidence of persistence of fetal circulation with thick muscular and adventitial layers due to the maintenance of a fetal-type high pulmonary vascular resistance, and evidence of congenital pneumonia with neutrophilic granulocytes in the lumen of the pulmonary tree. Histologic examination of the lung tissue may reveal abnormal vascular development, such as in alveolar capillary dysplasia, leading to nonfunctional air–blood interfaces ( Fig.…”

Section: Histologymentioning

confidence: 99%

Stillbirth Investigations: An Iconographic and Concise Diagnostic Workup in Perinatal Pathology

2023

View full text Add to dashboard Cite

Background Stillbirth is a dramatic event for the parents, health care team, and anyone close to the expectant parents. Multidisciplinary team (MDT) meetings are essential to improve communication in health care. We review the most frequent findings discussed at MDT meetings. Methods A PubMed search was conducted through December 2021 since the inception (1965) using clinical queries with the key terms “stillbirth” AND “investigation” AND “pathology” AND “human.” The search strategy included reviews, meta-analyses, randomized controlled trials, clinical trials, and observational studies. This systematic review is based on, but not limited to, the search results. It is the experience of more than 30 years of pediatrics, obstetrics, and pathology staff. Results Two hundred and six articles were screened and complemented through the perusal of congressional activities and personal communications. Pathological findings following perinatal death can be divided into macroscopic, histologic, and placental findings. The placenta is crucial in fetal medicine and is key in determining the cause of stillbirth in a substantial number of events. Perinatal lung disease is essential to evaluate the response of newborns to extrauterine life and address newborns' outcomes appropriately. Conclusions Stillbirth remains one of the less explored areas of medicine, and we can determine the cause in a limited number of cases. Nevertheless, placental pathology is critical in the etiology discovery pathway. Accurate investigations and discussion of photography-supported findings are vital in promoting communication at MDT meetings.

show abstract

Section: Histologymentioning

confidence: 99%

Stillbirth Investigations: An Iconographic and Concise Diagnostic Workup in Perinatal Pathology

2023

View full text Add to dashboard Cite

show abstract

“…All premature newborn babies demonstrate a defect in SP-A & D maturation, which used to be responsible for a high incidence of pulmonary morbidity and mortality (Dekowski & Holtzman 1998). These infants suffer from increased pulmonary infections, an increased airway sensitivity to oxygen, leading to bronchopulmonary dysplasia (BPD) and many of the survivors became respiratory cripples.…”

Section: Defects In Collectinsmentioning

confidence: 99%

Clinical Significance of Functional Aberrations in Macrophage and NK Cells, in Type-1 Cytokines and in Lectin-Binding Molecules

Handzel

2002

Advances in Experimental Medicine and Biology

View full text Add to dashboard Cite

Surfactantsubstitutionstherapie

Speer

2002

Monatsschr Kinderheilkd

View full text Add to dashboard Cite

Surfactant replacement therapy is a major breakthrough in neonatal medicine.Prophylaxis or treatment of neonatal respiratory distress syndrome (RDS) with various surfactant preparations is now a clinical reality. With either strategy the incidence of air leaks and mortality is reduced; more babies with RDS survive without signs of chronic lung disease.The earlier the treatment, the better the outcome.An initial dose of 100 mg/kg can be recommended for all natural preparations, and some babies may benefit from multiple dose treatment.Metaanalyses show a consistent advantage of natural surfactant preparations over the currently available synthetic ones.There is growing evidence that surfactant may also be beneficial in pulmonary diseases of the newborn which are characterized by inactivation of the surfactant system such as meconium aspiration syndrome or neonatal pneumonia.

show abstract

Surfactant Replacement Therapy

Cited by 17 publications

References 129 publications

Stillbirth Investigations: An Iconographic and Concise Diagnostic Workup in Perinatal Pathology

Stillbirth Investigations: An Iconographic and Concise Diagnostic Workup in Perinatal Pathology

Clinical Significance of Functional Aberrations in Macrophage and NK Cells, in Type-1 Cytokines and in Lectin-Binding Molecules

Surfactantsubstitutionstherapie

Contact Info

Product

Resources

About