2023
DOI: 10.1042/bsr20230504
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Surfactant replacement therapy as promising treatment for COVID-19: an updated narrative review

Khaled Khudadah,
Alaa Ramadan,
Ahmed Othman
et al.

Abstract: Patients with COVID-19 exhibit similar symptoms to neonatal respiratory distress syndrome. SARS-CoV-2 spike protein has been shown to target alveolar type 2 lung cells which synthesize and secrete endogenous surfactants leading to acute respiratory distress syndrome in some patients. This was proven by post-mortem histopathological findings revealing desquamated alveolar type 2 cells. Surfactant use in patients with COVID-19 respiratory distress syndrome results in marked improvement in respiratory parameters … Show more

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Cited by 8 publications
(4 citation statements)
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“…Such a shift only occurs due to significant damage to the AT2 cells and the depletion of phosphatidylcholine. The H-type presentation results in high stiffness (reduced compliance), resembling a premature infant's lungs (lack of sufficient surfactant production) [25][26][27].…”
Section: Discussionmentioning
confidence: 99%
“…Such a shift only occurs due to significant damage to the AT2 cells and the depletion of phosphatidylcholine. The H-type presentation results in high stiffness (reduced compliance), resembling a premature infant's lungs (lack of sufficient surfactant production) [25][26][27].…”
Section: Discussionmentioning
confidence: 99%
“…Variables such as mechanical ventilation technique, treatment schedule, provided dose, administration mode, and the exact formulation used were all considered. 89 …”
Section: Pulmonary Sps and Covid‐19mentioning
confidence: 99%
“…Variables such as mechanical ventilation technique, treatment schedule, provided dose, administration mode, and the exact formulation used were all considered. 89 Employing respiratory SPs as biomarkers to assess the severity of COVID-19 has both advantages and disadvantages. Their direct association with lung function makes them especially intriguing in this context.…”
Section: Sp-dmentioning
confidence: 99%
“…At variance with the pediatric environment, the administration of surfactant as a treatment for acute hypoxemic respiratory failure in adult patients has not been demonstrated to be effective . Nevertheless, the physiologic role of the surfactant in maintaining normal aeration and ventilation is unequivocally proven and accepted.…”
mentioning
confidence: 99%