Surfactant Replacement Therapy for Pulmonary Diseases

Pramanik, Arun K.; Holtzman, Ronald B.; Merritt, T. Allen

doi:10.1016/s0031-3955(16)38616-3

Cited by 34 publications

(16 citation statements)

References 60 publications

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“…Singh et al 24 have reported 53% survival for these babies. Exogenous surfactant therapy has been shown to reduce the mortality rate, requirements for mechanical ventilation and air leak complications in HMD 25 . We used it only 8 of our patients because of the high cost and difficulty in procuring it on time.…”

Section: Resultsmentioning

confidence: 99%

Indication and short term outcome of Mechanical Ventilation in Neonates in a tertiary care hospital

Jahan¹,

Haque

Mannan³

et al. 2017

Bangladesh J Med Sci

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Background: Mechanical ventilation of newborn has been practiced for several years with advances in many ways. As compared to the western world, neonatal ventilation in our country started in recent years.Subjects, Methods and Results: A retrospective chart review was conducted to analyze the common indications and outcome of neonates requiring mechanical ventilation in neonatal intensive care unit at Ad-Din Medical College Hospital from January 2012 to July 2013. Fifty eight neonates were ventilated over a period of 19 months of whom 39 (67.24%) survived. Respiratory distress syndrome was the commonest indication for ventilation (32.75%), followed by Perinatal asphyxia (18.96%), Pneumonia (13.79%), Neonatal Sepsis (13.79%), Meconium aspiration syndrome 6(10.16%) & Pneumothorax 6 (10.16%). Among the babies who survived, 35(89.74%) were managed solely with conventional ventilator and 4 babies required both conventional and High Frequency Oscillatory (HFOV) ventilation. Survival rate was higher where birth weight >2500gm (76.19%) and gestational age 34-37 weeks (88.88%). Survival rates was (69.23%) in <30 weeks and 60% in <1000 g. Prolong ventilator support was needed for Respiratory Distress Syndrome without surfactant (mean 254 hrs), Perinatal asphyxia (mean 187hrs) and Neonatal sepsis (mean 187hrs). Common complications were Pneumonia (12.06%), Pneumothorax (10.34%), sepsis (8.6%) & Pulmonary hemorrhage (3.4%). Survival rate was higher in babies requiring mechanical ventilation for respiratory distress syndrome (84.21%).Conclusion: Use of surfactant could decrease the duration of ventilation and mortality further in babies with respiratory distress syndrome.Bangladesh Journal of Medical Science Vol.16(1) 2017 p.24-28

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Section: Resultsmentioning

confidence: 99%

Indication and short term outcome of Mechanical Ventilation in Neonates in a tertiary care hospital

Jahan¹,

Haque

Mannan³

et al. 2017

Bangladesh J Med Sci

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“…Mostly because of the increased number of surviving infants with shorter gestation [4,5], the estimated incidence of NCLD of about 30% of all ventilated newborns has not changed since the original description of BPD [6]. NCLD is now the most prevalent chronic respiratory disorder of infancy.Expectations of a decrease in the incidence of NCLD as a result of new treatments like surfactant administration to the high-risk group [7] and more sophisticated artificial ventilation [8], have not as yet been met, although new techniques are being developed to meet the challenge [9]. Moreover, a population of very small preterm babies has recently been recognized who initially have no or only mild pulmonary disease requiring no respiratory support, but subsequently develop NCLD [3,5,10], suggesting that respiratory support is not a prerequisite for developing NCLD [6,11,12].…”

mentioning

confidence: 99%

Pulmonary function in infants with neonatal chronic lung disease with or without hyaline membrane disease at birth

Merth¹,

Winter²,

Zonderland³

et al. 1997

Eur Respir J

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The clinical and radiological picture of bronchopulmonary dysplasia (BPD) following prolonged mechanical ventilation and administration of high concentrations of oxygen for hyaline membrane disease (HMD), described in 1967, has become relatively rare [1]. With the advent of: antenatal corticosteroids; more gentle application of mechanical ventilation; judicious administration of fluids, nutrients and oxygen; early closure of a patent ductus arteriosus; and surfactant administration, a milder form is now more prevalent [2]. The term neonatal chronic lung disease (NCLD) is currently preferred [3]. Mostly because of the increased number of surviving infants with shorter gestation [4,5], the estimated incidence of NCLD of about 30% of all ventilated newborns has not changed since the original description of BPD [6]. NCLD is now the most prevalent chronic respiratory disorder of infancy.Expectations of a decrease in the incidence of NCLD as a result of new treatments like surfactant administration to the high-risk group [7] and more sophisticated artificial ventilation [8], have not as yet been met, although new techniques are being developed to meet the challenge [9]. Moreover, a population of very small preterm babies has recently been recognized who initially have no or only mild pulmonary disease requiring no respiratory support, but subsequently develop NCLD [3,5,10], suggesting that respiratory support is not a prerequisite for developing NCLD [6,11,12].Studies published so far have described abnormal pulmonary mechanics in infants who developed NCLD following ventilatory treatment for HMD [13][14][15][16][17][18][19][20]. Abnormal respiratory function is frequently seen as a consequence of lung damage associated with the level of treatment. On the other hand, therapeutic intervention is likely to be necessary if immaturity or prematurity are associated with compromised respiratory function at birth [21]. Only one study included both ventilated and nonventilated preterm infants [17]; in that study asymptomatic infants had normal lung function by the age of 1 yr. At school age in children born prematurely, airway diameter, as inferred from forced expiratory flows, was related only to birth weight and not to the level of respiratory therapy at birth [22,23].In the present study we analysed the association between a history of HMD, difference in ventilatory support We conclude that birth weight is the major determinant of the development of neonatal chronic lung disease. At 6 and 12 months corrected age, the abnormal pulmonary function is not associated with prior hyaline membrane disease.

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“…(Lim et al, 1998) identified a sudden and extremely major progress in FiO2, mean airway pressure, arterial/alveolar oxygen tension ratio and ventilatory index in neonates with respiratory distress syndrome (RDS) requiring mechanical ventilation with FiO2 of > or = 40% who were treated with Survanta. A similar study conducted by (Pramanik et al, 1993) stated that pulmonary surfactant agents which are artificial or non-human source given as preventive or lifesaving treatment efficiently decrease death rate among RDS patients. Eighty one of the subjects were on invasive mechanical ventilator with a mean duration of 40 days.…”

Section: Resultsmentioning

confidence: 84%

Incidence and Outcome of Surfactant Therapy in Premature Neonates in ICU of KAMC

Enezi¹,

Mohan²,

Alghamdi³

et al. 2018

Int.J.Curr.Microbiol.App.Sci

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Surfactant Replacement Therapy for Pulmonary Diseases

Cited by 34 publications

References 60 publications

Indication and short term outcome of Mechanical Ventilation in Neonates in a tertiary care hospital

Indication and short term outcome of Mechanical Ventilation in Neonates in a tertiary care hospital

Pulmonary function in infants with neonatal chronic lung disease with or without hyaline membrane disease at birth

Incidence and Outcome of Surfactant Therapy in Premature Neonates in ICU of KAMC

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