Surfactant stabilised colloidal cholesterol

Mukhopadhyay, L; Bhattacharyya, P.; Das, Anindita; Moulik, Satya P.

doi:10.1007/bf00660097

Cited by 8 publications

(5 citation statements)

References 17 publications

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“…1d). Previous studies have shown that CHOL has a negative surface charge in the pH range 2.0-10.5 [31,32]. On the other hand, nonionic surfactants and MB have no electrical charge; therefore, the electrical surface charge of the vesicle depends only on the amount of cholesterol.…”

Section: Effect Of Independent Variables On Zpmentioning

confidence: 98%

Methylene blue-loaded niosome: preparation, physicochemical characterization, and in vivo wound healing assessment

Farmoudeh

Âkbari

Saeedi

et al. 2020

Drug Deliv. and Transl. Res.

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Following skin injury, the overproduction of reactive oxygen species (ROS) during the inflammatory phase can cause tissue damage and delay in wound healing. Methylene blue (MB) decreases mitochondrial ROS production and has antioxidant effects. The authors aimed to prepare MB-loaded niosomes using the ultra-sonication technique as a green formulation method. A Box-Behnken design was selected to optimize formulation variables. The emulsifier to cholesterol ratio, HLB of mixed surfactants (Span 60 and Tween 60), and sonication time were selected as independent variables. Vesicle size, zeta potential (ZP), and drug entrapment capacity percentage were studied as dependent variables. The optimized formulation of niosomes showed spherical shape with optimum vesicle size of 147.8 nm, ZP of − 18.0 and entrapment efficiency of 63.27%. FTIR study showed no observable interaction between MB and other ingredients. In vivo efficacy of optimized formulation was evaluated using an excision wound model in male Wistar rat. Superoxide dismutase (SOD, an endogenous antioxidant) and malondialdehyde (MDA, an end product of lipid peroxidation) levels in skin tissue samples were evaluated. After 3 days, MDA was significantly decreased in niosomal gel-treated group, whereas SOD level was increased. Histological results indicate rats that received niosomal MB were treated effectively faster than other ones.

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Section: Effect Of Independent Variables On Zpmentioning

confidence: 98%

Methylene blue-loaded niosome: preparation, physicochemical characterization, and in vivo wound healing assessment

Farmoudeh

Âkbari

Saeedi

et al. 2020

Drug Deliv. and Transl. Res.

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“…The formation of the supramolecular colloidal aggregates reported here is caused by the sudden change in the solvent quality (polarity, hydrogen bonding, apolar interactions) of the solution. Addition of a co-solvent [43][44][45][46][47] which is miscible with the good initial organic solvent but which is selective for specific moieties of b-sitosterolin induces the self-assembly of this molecule into supramolecular aggregates as schematically summarized in Fig. 5.…”

Section: Self-assembly Of B-sitosterolinmentioning

confidence: 99%

Edible supramolecular chiral nanostructures by self-assembly of an amphiphilic phytosterol conjugate

2012

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We study the self-assembly of a food-grade glucose-b-sitosterol conjugate in bulk and in solution by small angle X-ray scattering (SAXS) and atomic force microscopy (AFM). The amphiphilic behavior of the glucose-b-sitosterol conjugate, combined with the chirality of both its moieties, leads in solutions to the aggregation into supramolecular chiral aggregates with plate-like, spherical and helical ribbon configurations, depending on concentration and solvent quality. Owing to the crucial role of phytosterols in replacing cholesterol content and the need for functional edible fibrils with enhanced nutritional value, this system shows great promise in the struggle for the design of new functional food building blocks with targeted properties.

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“…[29][30][31][32] Recently the same method was used to prepare cholesterol particles. [33][34][35][36] The precipitation of the particles is caused by a change in the solvent quality of the fluid phase, in which the material to be precipitated is initially present, by mixing it with a second fluid phase (usually water) which is miscible with the organic phase but which is not a good solvent for the dissolved material.…”

Section: Particle Synthesismentioning

confidence: 99%

“…Similar surface properties were found in the case of CH. 36,45 Contributions to the negative surface charge could also be made by naturally present minor contaminants of organic molecules that have ionisable groups (e.g. organic acids).…”

Section: Particle Morphologymentioning

confidence: 99%

Colloidal phytosterols: synthesis, characterization and bioaccessibility

et al. 2010

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We demonstrate the synthesis of phytosterol colloidal particles using a simple food grade method based on antisolvent precipitation in the presence of a non-ionic surfactant. The resulting colloidal particles have a rod-like shape with some degree of crystallinity. The colloidal dispersions display good stability assured by surface charge, due to the presence of water and hydroxyl groups on the particle surface, and by steric stabilisation, due to the presence of a non-ionic stabiliser. In vitro bioaccessibility experiments demonstrated that colloidal phytosterol can be effectively solubilised in model dietary mixed micelles and the micellar cholesterol concentration can be effectively reduced by 47% within two hours.

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Surfactant stabilised colloidal cholesterol

Cited by 8 publications

References 17 publications

Methylene blue-loaded niosome: preparation, physicochemical characterization, and in vivo wound healing assessment

Methylene blue-loaded niosome: preparation, physicochemical characterization, and in vivo wound healing assessment

Edible supramolecular chiral nanostructures by self-assembly of an amphiphilic phytosterol conjugate

Colloidal phytosterols: synthesis, characterization and bioaccessibility

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