Surfactant-stabilized microbubbles as ultrasound contrast agents: stability study of Span 60 and Tween 80 mixtures using a Langmuir trough

Singhal, Sarita; Moser, Chris; Wheatley, Margaret A.

doi:10.1021/la00033a027

Cited by 62 publications

(44 citation statements)

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“…Microbubbles stabilized by mixtures of the synthetic surfactants SPAN-40 and TWEEN-40 were formulated by Wheatley et al17, 18 The SPAN/TWEEN solution was sonicated in the presence of air to form stable microbubbles. Using a Langmuir trough, they were able to establish the correct ratio of SPAN to TWEEN (roughly 1:1) to use for maximum film stability.…”

Section: Microbubble Compositions and Physicochemical Propertiesmentioning

confidence: 99%

Microbubble compositions, properties and biomedical applications

Sirsi

Borden

2009

Bubble Science, Engineering & Technology

510

484

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Over the last decade, there has been significant progress towards the development of microbubbles as theranostics for a wide variety of biomedical applications. The unique ability of microbubbles to respond to ultrasound makes them useful agents for contrast ultrasound imaging, molecular imaging, and targeted drug and gene delivery. The general composition of a microbubble is a gas core stabilized by a shell comprised of proteins, lipids or polymers. Each type of microbubble has its own unique advantages and can be tailored for specialized functions. In this review, different microbubbles compositions and physiochemical properties are discussed in the context of current progress towards developing novel constructs for biomedical applications, with specific emphasis on molecular imaging and targeted drug/gene delivery.

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Section: Microbubble Compositions and Physicochemical Propertiesmentioning

confidence: 99%

Microbubble compositions, properties and biomedical applications

Sirsi

Borden

2009

Bubble Science, Engineering & Technology

510

484

View full text Add to dashboard Cite

show abstract

“…The results obtained reveal that durability of this layer depends on the ratio of esters in the total concentration of additives. After considering the literature data [17][18][19][20][21][22][23] it can be concluded that ordered structures, formed by both types of the esters tested, are crucial in creation of the adsorption film.…”

Section: Discussionmentioning

confidence: 99%

“…They can be obtained from renewable natural resources and they are cheap. They have a wide range of applications in production of cosmetic, food and industrial emulsions [17][18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Paraffin oil solutions of the mixture of sorbitan monolaurate–ethoxylated sorbitan monolaurate as lubricants

Wasilewski¹,

Sułek²

2006

Wear

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“…29 Several different combinations of a high HLB surfactant and a low HLB surfactant have been used to produce stable emulsions. [29][30][31][32] According to the obtained results, T60, T80, and B58 were selected as hydrophilic surfactant for aqueous phase and span 20, 40, 60, and 80 were selected as hydrophobic surfactant for oil phase, as shown in Table IV.…”

Section: Optimization Of Emulsion Solution Conditionsmentioning

confidence: 99%

Biphasic, tough composite core/shell PCL/PVA‐GEL nanofibers for biomedical application

Akbarzadeh

Pezeshki‐Modaress

Zandi

2019

J of Applied Polymer Sci

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Emulsion electrospinning using natural and synthetic polymers, including two dissimilar materials is a promising technique for nanofibers fabrication in a core/shell configuration for tissue engineering, controlled or sustained drug delivery and dressing applications. In this study, we designed and fabricated core/shell nanofibers based on polycaprolactone (PCL) as core material and poly(vinyl alcohol) (PVA)‐gelatin (GEL) blend as shell materials (PCL/PVA‐GEL) to achieve high mechanical properties, good cell growth, and proliferation via emulsion electrospinning. The effect of water to acetic acid ratio in the solvent system (8:2, 7:3, 6:4, 5:5) and also type and concentration (3, 5, 7 w/v %) of surfactant on emulsion stability and nanofibers morphology were investigated. The emulsion containing 2% Tween80 and 1% Span60 as surfactants were selected by considering the stability of emulsion and uniform fiber morphology. In the tensile strength and elongation at break, 53 and 8% increase in the crosslinked wet state of the PCL/PVA‐GEL nanofibers compared with PVA‐GEL nanofibers were observed respectively. The cell culture results indicated that the PCL/PVA‐GEL nanofibers surface has presented suitable interaction with fibroblast cells and cells attached and proliferated well on the fabricated substrate within 24 and 48 hours and also would be a good candidate for biomedical applications. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48713.

show abstract

Surfactant-stabilized microbubbles as ultrasound contrast agents: stability study of Span 60 and Tween 80 mixtures using a Langmuir trough

Cited by 62 publications

References 0 publications

Microbubble compositions, properties and biomedical applications

Microbubble compositions, properties and biomedical applications

Paraffin oil solutions of the mixture of sorbitan monolaurate–ethoxylated sorbitan monolaurate as lubricants

Biphasic, tough composite core/shell PCL/PVA‐GEL nanofibers for biomedical application

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