Surfactant systems: their use in drug delivery

Lawrence, M. Jayne

doi:10.1039/cs9942300417

Cited by 336 publications

(227 citation statements)

References 25 publications

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“…It is known that the solubility of sparingly water soluble drugs can be increased through the addition of surfactants [2]. Solubilization of water insoluble drugs by micelles has long been investigated as a means of improving solubility for drug delivery [3] and the incorporation of a wide variety of drugs into micelles formed from a large variety of surfactants in particular non-ionic surfactants have been studied [4,5]. Nystatin release from a chewing gum formulation as drug delivery device with addition of non-ionic surfactants Tween 60 (polyoxyethylene sorbitan mono stearate), Cremophor RH 40 (polyoxyl 40 hydrogenated castor oil) and Panodan AB 90 (diacetyl tartaric acid esters of mono and diglycerides of vegetable fats) was studied by Andersen et al [6].…”

Section: Introductionmentioning

confidence: 99%

Effects of solubilizing surfactants and loading of antiviral, antimicrobial, and antifungal drugs on their release rates from ethylene vinyl acetate copolymer

Tallury¹,

K.²,

Thaw³

et al. 2007

Dental Materials

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Objectives-This study investigates the effects of surfactants and drug loading on the drug release rate from ethylene vinyl acetate (EVA) copolymer. The release rate of nystatin from EVA was studied with addition of non-ionic surfactants Tween 60 and Cremophor RH 40. In addition, the effect of increasing drug load on the release rates of nystatin, chlorhexidine diacetate and acyclovir is also presented.Method-Polymer casting solutions were prepared by stirring EVA copolymer and nystatin (2.5 wt %) in dichloromethane. Nystatin and surfactants were added in ratios of (1:1), (1:2) and (1:3). Drug loading was studied with 2.5, 5.0, 7.5, and 10.0% wt. proportions of nystatin, chlorhexidine diacetate and acyclovir incorporated into a separate polymer. Three drug loaded polymer square films (3cm × 3cm × 0.08 cm) were cut from dry films to follow the kinetics of drug release at 37°C. 10 ml of either distilled water or PBS was used as the extracting medium that was replaced daily. PBS was used for nystatin release with addition of surfactants and water was used for the study on drug loading and surfactant release. The rate of drug release was measured by UVspectrophotometer. The amount of surfactant released was determined by HPLC.Results-The release of nystatin was low in PBS and its release rate increased with the addition of surfactants. Also, increasing surfactant concentrations resulted in increased drug release rates. The release rates of chlorhexidine diacetate (p<0.0001), acyclovir (p<0.0003) and nystatin (p<0.0017) linearly increased with increasing drug loads. The amount of surfactants released was above the CMC.Significance-This study demonstrates that the three therapeutic agents show a sustained rate of drug release from EVA copolymer over extended periods of time. Nystatin release in PBS is low owing to its poor solubility. Its release rate is enhanced by addition of surfactants and increasing the drug load as well.

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Section: Introductionmentioning

confidence: 99%

Effects of solubilizing surfactants and loading of antiviral, antimicrobial, and antifungal drugs on their release rates from ethylene vinyl acetate copolymer

Tallury¹,

K.²,

Thaw³

et al. 2007

Dental Materials

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“…On the other hand, micelles injected into the body are usually subjected to severe dilution and this normally leads to their dissociation and a rapid release of physically encapsulated drugs. Consequently, their effectiveness in drug delivery and their in vivo application are considerably reduced [206]. The use of amphiphilic polymeric unimolecular micelles can help to eliminate problems associated with the dissociation and the large sizes of polymeric micelles.…”

Section: Methodsmentioning

confidence: 99%

Polyester Dendrimers: Smart Carriers for Drug Delivery

Twibanire

Grindley

2014

Polymers

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Polyester dendrimers have been shown to be outstanding candidates for biomedical applications. Compared to traditional polymeric drug vehicles, these biodegradable dendrimers show excellent advantages especially as drug delivery systems because they are non-toxic. Here, advances on polyester dendrimers as smart carriers for drug delivery applications have been surveyed. Both covalent and non-covalent incorporation of drugs are discussed.

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“…emulsions, suspensions, foams, gels and composites) (35). Moreover, they can be used as drug vehicles/carriers or targeting systems (36) and in topical formulations to enhance drug penetration across epithelial barriers (37,38). There are several types of surfactants; anionic (e.g.…”

Section: Materials Used For Drug Deliverymentioning

confidence: 99%

Porous Inorganic Drug Delivery Systems—a Review

et al. 2017

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Innovative methods and materials have been developed to overcome limitations associated with current drug delivery systems. Significant developments have led to the use of a variety of materials (as excipients) such as inorganic and metallic structures; marking a transition from conventional polymers. Inorganic materials, especially those possessing significant porosity, are emerging as good candidates for the delivery of a range of drugs (anti-biotics, anti-cancer and anti-inflammatories), providing several advantages in formulation and engineering (encapsulation of drug in amorphous form, controlled delivery and improved targeting). This review focuses on key selected developments in porous drug delivery systems. The review provides a short broad overview of porous polymeric materials for drug delivery before focusing on porous inorganic materials (e.g. Santa Barbara Amorphous (SBA) and Mobil Composition of Matter (MCM)) and their utilisation in drug dosage form development. Methods for their preparation and drug loading thereafter are detailed. Several examples of porous inorganic materials, drugs used and outcomes are discussed providing the reader with an understanding of advances in the field and realistic opportunities.

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Surfactant systems: their use in drug delivery

Cited by 336 publications

References 25 publications

Effects of solubilizing surfactants and loading of antiviral, antimicrobial, and antifungal drugs on their release rates from ethylene vinyl acetate copolymer

Effects of solubilizing surfactants and loading of antiviral, antimicrobial, and antifungal drugs on their release rates from ethylene vinyl acetate copolymer

Polyester Dendrimers: Smart Carriers for Drug Delivery

Porous Inorganic Drug Delivery Systems—a Review

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