Surfactants in suspension systems

Attwood, David; Florence, Alexander T.

doi:10.1007/978-94-009-5775-6_9

Cited by 6 publications

(2 citation statements)

References 58 publications

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“…The study of surfactant adsorption at fluid interfaces is based on the Gibbs adsorption equation [7,8]. It shows the extension of adsorption in a liquid surface, determined from surface tension data.…”

Section: Evaluation Of the Surface Excess Concentration Of Ionic And ...mentioning

confidence: 99%

Molecular behavior of ionic and nonionic surfactants in saline medium

Santos

Neto

Moura

et al. 2009

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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Section: Evaluation Of the Surface Excess Concentration Of Ionic And ...mentioning

confidence: 99%

Molecular behavior of ionic and nonionic surfactants in saline medium

Santos

Neto

Moura

et al. 2009

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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“…It can be observed that, on increasing the concentration of ondansetron, the adsorption of Aquateric latex particles also increases. The adsorption is a type S isotherm that has been presented in other works (12), which explains the adsorption of the drug in progressive layers on the polymer particles.…”

Section: Adsorption Studymentioning

confidence: 86%

Adsorption-Desorption of Ondansetron on Latex Particles

Llacer

Ruíz

Parera

et al. 2000

Drug Development and Industrial Pharmacy

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Engineering Budesonide Microparticles for Enhancing Pulmonary Targeting: Validation through In Vivo Investigations

Kumar,

Verma,

Patel

et al. 2024

Part & Part Syst Charact

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The study aimed to develop and evaluate budesonide inhalation micro‐suspension to target inflammation in the lower trachea and bronchi. Initially, the slurry phase is prepared by dispersing the drug (0.25 and 0.5 mg ml−1) in the Water for Injection with polysorbate 80. The slurry is mixed with the aqueous phase comprising other excipients. The mixture is further subjected to the treatment with homogenizer. The prepared formulations are subjected to various physio‐chemical analysis like description, density, pH, osmolality, viscosity, shelf life, impurities, assay, particle size, etc. Andersen cascade impactor is used to estimate the aerodynamic performance. In vivo analysis is initiated with the induction of Asthma in Sprague Dawley rats by ovalbumin challenge intranasally and the treatment is given with the aid of a nebulizer. Lastly, the biochemical estimations are carried out in blood and bronchoalveolar lavage fluid (BALF). The lungs are also subjected to morphological and histological evaluations. The physio‐chemical and analytical examination indicated a stable formulation that is compliant with the standard guidelines. The D90 value of the test formulation is ≤4.5 µm. Cascade impactor evaluation estimated almost, 2–10% higher amount of budesonide reaching the target region as compared to the marketed product. Test formulation attenuated the manifestation of ovalbumin‐induced asthma through suppression of inflammatory cell count in blood and BALF, and modulation of Lactate dehydrogenase and Alkaline Phosphatase levels which is further confirmed by histopathological analysis. The formulated budesonide micro‐suspension demonstrated stability, safety, and efficient delivery to the target site.

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Surfactants in suspension systems

Cited by 6 publications

References 58 publications

Molecular behavior of ionic and nonionic surfactants in saline medium

Molecular behavior of ionic and nonionic surfactants in saline medium

Adsorption-Desorption of Ondansetron on Latex Particles

Engineering Budesonide Microparticles for Enhancing Pulmonary Targeting: Validation through In Vivo Investigations

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