Surfactin: Biosynthesis, Genetics and Potential Applications

Sen, Ramkrishna

doi:10.1007/978-1-4419-5979-9_24

Cited by 79 publications

(55 citation statements)

References 84 publications

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“…Surfactin is one one of the most efficient surface active agents as it reduces the surface tension at the water–air interface from 72 to 27–30 mN/m (Sen 2010). By contrast, iturin reduces the surface tension of water to 43 mN/m (Jacques 2011).…”

Section: Discussionmentioning

confidence: 99%

Lipid composition in a strain of Bacillus subtilis, a producer of iturin A lipopeptides that are active against uropathogenic bacteria

Bernat

Paraszkiewicz

Siewiera

et al. 2016

World J Microbiol Biotechnol

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Urinary tract infections are a common disease in humans. Therefore, new methods are needed to destroy biofilms that are formed by uropathogens. Iturin A lipopeptides (LPs) C14 and C15 are potent biosurfactants synthetized by the Bacillus subtilis I 0 1a strain. The biological activity of extracted LPs was confirmed by examining extracts from I 0 1a cultures against uropathogenic bacteria that had been isolated from biofilms on urinary catheters. Compared with cultures of DSM 3257, which produce surfactin at a relatively low level, the extract obtained from strain I 0 1a exhibited a greater inhibitory effect against both planktonic and sessile forms of Escherichia coli, Serratia marcescens, Enterobacter cloacae, Proteus mirabilis, Citrobacter freundii and Enterococcus faecalis. Moreover, cyclic LP biosurfactants may disturb the integrity of cytoplasmic membranes; therefore, we investigated the effects of synthetized LPs on fatty acids and phospholipids of B. subtilis. LPs and lipids were analyzed using GC-MS, LC-MS/MS and MALDI-TOF/TOF techniques. Compared with B. subtilis DSM 3257, membranes of the I 0 1a strain were characterized by an increased amount of anteiso fatty acids and a ten-fold higher ratio of phosphatidylglycerol (PG)-to-phosphatidylethanolamine (PE). Interestingly, in cultures of B. subtilis DSM 3257 supplemented with LP extracts of the I 0 1a strain, the PG-to-PE ratio was fourfold higher, and the amount of anteiso fatty acids was also increased.

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Section: Discussionmentioning

confidence: 99%

Lipid composition in a strain of Bacillus subtilis, a producer of iturin A lipopeptides that are active against uropathogenic bacteria

Bernat

Paraszkiewicz

Siewiera

et al. 2016

World J Microbiol Biotechnol

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“…Biosurfactants have anti-adhesive properties that inhibit biofilm production and the adhesion of bacteria and infection sites [119,123,124]. Seydlová et al have shown that surfactin inhibits the formation of biofilms by Salmonella typhimurium, Salmonella enterica, Escherichia coli and Proteus mirabilis [119].…”

Section: Anti-adhesive Applicationsmentioning

confidence: 97%

“…Induces formation of ion channels in lipid bi-layer membranes [112][113][114][115][116][117][118] Anti-inflammatory Inhibiting platelet cytosolic phospholipase [33, Anti-adhesive Inhibition of biofilm formation [119,123,124] Environmental applications Mechanisms…”

Section: Surfactin Application Potentialsmentioning

confidence: 99%

Applications of a lipopeptide biosurfactant, surfactin, produced by microorganisms

Chen

Juang

Wei

2015

Biochemical Engineering Journal

228

113

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“…Among the above mentioned biosurfactant types, the lipopeptides have achieved significant importance with their biological activities and structural characteristics [11][12][13]. The bacterial genera namely Bacillus, Pseudomonas and Arthrobacter are reported to produce such lipopeptide biosurfactants [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Biofilm inhibition and antimicrobial action of lipopeptide biosurfactant produced by heavy metal tolerant strain Bacillus cereus NK1

Sriram

Kalishwaralal

Deepak

et al. 2011

Colloids and Surfaces B: Biointerfaces

153

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Surfactin: Biosynthesis, Genetics and Potential Applications

Cited by 79 publications

References 84 publications

Lipid composition in a strain of Bacillus subtilis, a producer of iturin A lipopeptides that are active against uropathogenic bacteria

Lipid composition in a strain of Bacillus subtilis, a producer of iturin A lipopeptides that are active against uropathogenic bacteria

Applications of a lipopeptide biosurfactant, surfactin, produced by microorganisms

Biofilm inhibition and antimicrobial action of lipopeptide biosurfactant produced by heavy metal tolerant strain Bacillus cereus NK1

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