Surfactin-oleogel with therapeutic potential for inflammatory acne vulgaris induced by Propionibacterium acnes

Shan, Mengyuan; Meng, Fanqiang; Tang, Chao; Zhou, Libang; Lu, Zhaoxin; Lu, Yingjian

doi:10.1007/s00253-021-11719-8

Cited by 8 publications

(12 citation statements)

References 40 publications

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“…Surfactin significantly inhibited the expression of pro-inflammatory cytokines and mediators, and increased anti-inflammatory cytokine IL-10 expression in copper sulfate-stimulated zebrafish larvae [ 37 ]. Surfactin inhibited the expression of pro-inflammatory cytokines and mediators in the epidermis of Propionibacterium acnes -infected mice [ 38 ]. Surfactin also inhibited COX-2-dependent PGE 2 production in particulate matter-stimulated human gingival fibroblasts [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

Surfactin Containing Bacillus licheniformis-Fermented Products Alleviate Dextran Sulfate Sodium-Induced Colitis by Inhibiting Colonic Inflammation and the NLRP3 Inflammasome in Mice

Tsai

Wong

Hsu

et al. 2022

Animals

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Inflammatory bowel disease (IBD) is a non-infectious disease characterized by chronic inflammation of the gastrointestinal tract. Currently, management of IBD is still a clinical challenge. The purpose of this study was to investigate the therapeutic potential of surfactin containing Bacillus licheniformis-fermented products (SBLF) and commercial surfactin (CS) on the treatment of dextran sulfate sodium (DSS)-induced colitis in a mouse model. We found that mice that received drinking water containing 3% DSS developed significant colitis symptoms, including increased disease activity index, body weight loss, shortening of the colon length, splenomegaly, colonic inflammation and colonic NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome activation. Notably, orally received SBLF, CS or clinical anti-inflammatory drug 5-aminosalicylic acid improved DSS-induced colitis symptoms in mice. These findings show that SBLF can improve IBD in mice by reducing colonic inflammation and inhibiting the NLRP3 inflammasome activation, suggesting that SBLF has the potential to be used as a nutraceutical in humans or a feed additive in economic and companion animals for preventing IBD.

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Section: Discussionmentioning

confidence: 99%

Surfactin Containing Bacillus licheniformis-Fermented Products Alleviate Dextran Sulfate Sodium-Induced Colitis by Inhibiting Colonic Inflammation and the NLRP3 Inflammasome in Mice

Tsai

Wong

Hsu

et al. 2022

Animals

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“…Lipoperoxides inhibit keratinocyte proliferation and increase proinflammatory cytokine release [76]. They are also ligands for PPARy, a nuclear hormone receptor that, as previously referred, simplifies androgen-induced comedone evolution [75]. A cytokine mRNA study exposed significantly increased degrees of tumour necrosis factor-(TNF-) and interleukins in facial acne lesions.…”

Section: Cytokines and Inflammationmentioning

confidence: 91%

“…Lipoperoxides, especially those made when squalene breaks down, may be condemned [74]. According to one study, lipoperoxides are found in essentially higher combinations in the pimples of acne patients than in vigorous dermis [75]. Lipoperoxides inhibit keratinocyte proliferation and increase proinflammatory cytokine release [76].…”

Section: Cytokines and Inflammationmentioning

confidence: 99%

Endocrine Disorders and Hormonal Therapy for Adolescent Acne

Assawaruangsin¹

2022

ijcsrr

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Acne vulgaris is a worldwide disease which is mostly found in teenagers. This has a crucial impact on their life’s quality, particularly when endocrine disorders have been implicated. Current consideration regarding antibiotic stewardship, failing with antibiotic utilization, and the improvement of antibiotic-resistant Propionibacterium acnes, there are many treatment alternatives for pimple therapy have been acknowledged. A following analysis investigates hormonal treatments for the therapy of acne vulgaris.

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“…Additionally, acne patients have shown a significant reduction of the anti-inflammatory IL-10 expression. IL-10 modulates the production of cytokines, chemokines, nitric oxide, ROS, and costimulatory molecules, so its downregulation in acne increases inflammatory mechanisms. , …”

Section: Skin-related Conditionsmentioning

confidence: 99%

“…IL-10 modulates the production of cytokines, chemokines, nitric oxide, ROS, and costimulatory molecules, so its downregulation in acne increases inflammatory mechanisms. 73,74 Moreover, P. acnes PAMPs can induce the accumulation of neutrophils that, in turn, induces oxidative stress. Neutrophils release high amounts of lysosomal enzymes, NO, and reactive oxygen species (ROS) to counteract P. acnes colonization.…”

Section: Skin-related Conditionsmentioning

confidence: 99%

Potential Role of Oleanolic and Ursolic Acids from Food and Plant Materials as Natural Ingredients for the Cosmetic Industry: A Review

Mejía-Valdez

Antunes‐Ricardo

Martínez-Ávila

et al. 2023

ACS Food Sci. Technol.

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Cosmeceuticals have emerged as health and beauty aid products that integrate active ingredients from natural sources. Phytochemicals have prevailed in this market as an effective alternative toward different skin conditions. This is mainly due to the increasing demand for natural products that overcome the side effects of conventional treatments. Alopecia, acne, and skin aging are prevalent skin-related conditions worldwide. These conditions are characterized by high levels of inflammatory biomarkers and oxidative stress conditions. Oleanolic and ursolic acids are two biologically active pentacyclic triterpenoid isomeric compounds. They have shown strong potential for the prevention and treatment of diverse skin-related conditions through their effective antioxidant and anti-inflammatory capacity. This review presents the latest available information on the biological potential of oleanolic and ursolic acids, highlighting their cosmeceutical potential. In the pursuit of a better understanding of their potential as natural ingredients of dermatological relevance, graphical analysis is provided to propose the molecular mechanisms involved in the effects of each skin-related condition.

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Surfactin-oleogel with therapeutic potential for inflammatory acne vulgaris induced by Propionibacterium acnes

Cited by 8 publications

References 40 publications

Surfactin Containing Bacillus licheniformis-Fermented Products Alleviate Dextran Sulfate Sodium-Induced Colitis by Inhibiting Colonic Inflammation and the NLRP3 Inflammasome in Mice

Surfactin Containing Bacillus licheniformis-Fermented Products Alleviate Dextran Sulfate Sodium-Induced Colitis by Inhibiting Colonic Inflammation and the NLRP3 Inflammasome in Mice

Endocrine Disorders and Hormonal Therapy for Adolescent Acne

Potential Role of Oleanolic and Ursolic Acids from Food and Plant Materials as Natural Ingredients for the Cosmetic Industry: A Review

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