Background and ObjectivesPatients undergoing breast reconstruction following mastectomy are often admitted overnight. In 2020, our institution implemented a protocol change to discharge clinically stable patients immediately. In this study, we examine the safety of same‐day discharge following mastectomy and reconstruction.MethodsOur retrospective study included female adults undergoing mastectomy and immediate alloplastic reconstruction from August 2019 to January 2020, before implementation of the same‐day discharge protocol, and from March 2020 to September 2021, after the protocol implementation. Independent t‐test and chi‐square analysis was conducted to examine statistical differences.ResultsTwo hundred and eighty‐five patients were included. Forty‐two patients underwent reconstruction before the protocol change (Group 1) and 243 patients underwent reconstruction after the protocol change (Group 2). Group 2 had a greater percentage of prepectoral implant placement. There was no difference in demographics, complications, readmission, or reoperation. Within Group 2, 157 patients were discharged the same day (Group 2a) and 88 patients required overnight admission (Group 2b). Group 2b had higher body mass index, higher percentage of bilateral mastectomy, and larger mastectomy weights. Despite no differences in complications, Group 2b exhibited higher rates of requiring intravenous antibiotics and reoperation.ConclusionsPatients may be safely discharged the same day following mastectomy and alloplastic reconstruction without an increase in complications.