Surgeon volume and prognosis of patients with advanced papillary thyroid cancer and lateral nodal metastasis

Kim, H. I.; Kim, T. H.; Choe, Jun Ho; Kim, J.‐H.; Kim, Y. N.; Kim, S. W.; Chung, Jae Hoon

doi:10.1002/bjs.10655

Cited by 32 publications

(29 citation statements)

References 38 publications

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“…More prevalent detection of TC has increased the frequency of thyroid surgery and has led to the production of competent, high-volume surgeons in the tertiary care centers. In our previous study, the prognosis of advanced TC performed by high-volume surgeons was better than that performed by low-volume surgeons 27 . Our data showed that, after 2004, neck dissection was significantly performed more than prior to 2004.…”

Section: Discussionmentioning

confidence: 78%

Improved survival after early detection of asymptomatic distant metastasis in patients with thyroid cancer

Kim

Park

Jung

et al. 2019

Sci Rep

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The incidence of thyroid cancer (TC) has been increasing in many countries and concerns about overdiagnosis are also widely shared. However, early detection may be helpful in some high-risk TC patients, such as those with initial distant metastasis. We conducted this study to evaluate the usefulness of early detection in TC patients with initial distant metastasis. We retrospectively reviewed the clinical data of 13,249 TC patients, and found 127 patients with initial distant metastasis. Enrolled patients were divided into two groups according to the diagnostic periods; before and after 2004, when the early detection of TC by ultrasonography began in earnest in Korea. Patients were also divided into two groups according to the presence of symptoms. Prior to 2004, 33 patients (1.7% of TC patients) were diagnosed with TC with initial distant metastasis and 16 (48.5%) of them died. After 2004, 94 patients (0.8% of TC patients) were diagnosed with TC with initial distant metastasis and 29 (30.9%) of them died. Prior to 2004, the disease-specific death rates were similar between the asymptomatic and symptomatic groups (46.2% vs. 50.0%, P = 0.566). Conversely, after 2004, the asymptomatic group showed a significantly lower disease-specific death rate as compared with that of the symptomatic groups (17.2% vs. 60.0%; P < 0.001). Early detection had a significant positive impact on survival outcomes only after 2004, especially in asymptomatic TC patients with initial distant metastasis.

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Section: Discussionmentioning

confidence: 78%

Improved survival after early detection of asymptomatic distant metastasis in patients with thyroid cancer

Kim

Park

Jung

et al. 2019

Sci Rep

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“…The prognosis of papillary thyroid carcinoma is good. 10year survival rate more is than 90%, especially in young patients (98%) [12][13][14][15][16][17]. The factors affecting the prognosis included vascular invasion, nuclear atypia, tumor size and age.…”

Section: Resultsmentioning

confidence: 99%

Columnar Cell Variant of Papillary Thyroid Carcinoma: A Clinicopathologic Analystis

Zhang¹

2019

EJCBS

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Background: Papillary Thyroid Carcinoma (PTC) is the Most common thyroid malignancy disease, and it is more common in females. It happened in any age. Mean age at diagnosis is approximately 40 years old. There is history of neck irradiation in 5-10% patients. And non-neoplastic gland may show nuclear aberrations as a result. There is increased incidence in Hashimoto's thyroiditis, but not clear whether there is an increased incidence in Graves' disease. Columnar cell variant of papillary thyroid carcinoma is the rare subtype of PTC, which is reportedly about 0.17%. CCV-PTC was reported in 1986 by Evans for the first time. It is different from the typical papillary carcinoma, not only in morphology but also in biological behavior, and is more aggressive than typical papillary carcinoma. Objective: To study the clinical-pathological links and features of papillary thyroid carcinoma (Columnar cell variant) (CCV-PTC). Methods: 4 cases of CCV-PTC from Chengde medical college affiliated hospital were retrospectively analyzed, to observe its clinical features, histological, immunophenotype, and metastasis. And the literature of CCV-PTC were reviewed. Results: Out of the 4 patients, two male patients of 70 and 53 years old, two female patients of 64 and 68 years old. Microscopically, tumor cells arranged in multistage papillary structure, with pseudostratified columnar epithelium, same to gastrointestinal and lung metastatic carcinoma. IHC: Ki-67(5-15%), calcitonin(-), TG(+), ck19(-), TTF-1(+), CgA(-), SyN(-),ck(+/-). Conclusion: CCV-PTC is a special subtype of PTC with a more aggressive biological behavior, particularly among older people, Immunohistochemical method is helpful for the diagnosis.

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“…Although the surgical approach is the most important for the WDTC treatment, the question concerning the surgical intervention volume and long-term treatment results, in particular the patients survival, remains poorly studied. There are even the data refusing the interactions between the surgical intervention volume and the level of WDTC patient's survival: this interaction is underlined to be important only in cases of primary operations on great metastasizing tumors [22]. The majority of surgeons think the gland extirpation together with its tumor is a satisfactory volume of intervention in cases of small carcinomas which do not metastasize and do not invade to extrathyroid tissues (category Т1N0М0); it explains the excellent prognosis for the patient cohort having survived the same operation (Table 3).…”

Section: Resultsmentioning

confidence: 99%

“…in cases of more aggressive carcinomas (Table 3). Therefore, we cannot share the idea that the volume and type of surgical intervention do not exert on the level of patients survival [22].…”

Section: Groupsmentioning

confidence: 97%

Main Prognostic Factors for Well Differentiated Thyroid Cancer: Analis of Combined Patients Treatment Results during 20 Years after Surgery

Bb¹,

Ae²,

My³

et al. 2018

Thyroid Disorders Ther

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Background: In general, the prognosis in patients with well differentiated thyroid carcinoma (WDTC) is excellent. However, there are small cohorts of patients who experience a more aggressive form of disease which is often associated with certain poor prognostic factors. Identifying these patients at an early stage is imperative for guiding treatment decisions. The purpose of the work is to study the cumulative survival of patients with WDTC, depending on a number of clinical and biological characteristics of tumors. Methods: A retrospective cohort study of patients operated on WDTC in the period from 1995 to 2015 (5526 people). Each patient was analyzed according to age, gender, tumor size and characteristics of the TNM (7 editions), clinical stage, volume of surgery, number of points on the MACIS scale, risk group, number of courses of radioiodine treatment, result treatment and the term of postoperative observation. The construction of cumulative survival curves was made according to the Kaplan-Meier approach. To compare the cumulative survival index value in groups, the non-parametric Log-rank test was used. Results: The most unfavorable factors of the prognosis for patients with WDTC are such integrated indicators as the stage of disease IVb and IVc, as well as tumors of the T4b category. It is also unfavorable to recognize the age of patients over 60 years, the presence of distant metastases, the stage of disease IVa, the category of carcinomas T4a and the size of the tumor more than 40 mm. Other prognostic factors (invasion, multifocal tumor growth, metastasis of carcinoma to the lymph nodes, male sex, post-operative relapse), although they are probable predictive factors, but have somewhat less significance in analyzing the prognosis of survival of patients. Conclusion: Understanding the importance of certain prognostic factors of survival is extremely necessary, since they are the only indicators of the effectiveness of the diagnostic, medical and organizational work will reduce the number of patients who require aggressive treatments and, consequently, increase the duration and quality of their postoperative life.

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Surgeon volume and prognosis of patients with advanced papillary thyroid cancer and lateral nodal metastasis

Cited by 32 publications

References 38 publications

Improved survival after early detection of asymptomatic distant metastasis in patients with thyroid cancer

Improved survival after early detection of asymptomatic distant metastasis in patients with thyroid cancer

Columnar Cell Variant of Papillary Thyroid Carcinoma: A Clinicopathologic Analystis

Main Prognostic Factors for Well Differentiated Thyroid Cancer: Analis of Combined Patients Treatment Results during 20 Years after Surgery

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