Surgery and radiotherapy in vulvar cancer

Hullu, Joanne A. de; Zee, Ate G.J. van der

doi:10.1016/j.critrevonc.2006.02.008

Cited by 108 publications

(82 citation statements)

References 142 publications

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“…Apart from the indication when complete resection of the primary tumour could not be achieved [de Hullu and van der Zee, 2006], further recommendations are not clearly defined. Although lymph-node metastases, lymphangioinvasion and large primary tumours (≥4 cm) have been described to be correlated with increased risk for local recurrence, there are no clear treatment recommendations for radiotherapy to the vulva itself based on these findings [Burger et al 1995;].…”

Section: Recommendations For Radiotherapy In Intermediate-stage Vulvamentioning

confidence: 99%

Management of patients with vulvar cancer: a perspective review according to tumour stage

et al. 2013

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Treatment of patients with vulvar cancer is challenging for gynaecologic oncologists. Owing to the localization in a sensitive area, surgical radicality and the indication for adjuvant treatment have to be balanced with psychosocial aspects to treat patients adequately. Clinical management is therefore highly dependent on the tumour stage. For patients with early-stage disease (FIGO I-II) therapy mainly concentrates on surgery with resection of the primary tumour and staging of the groin lymph nodes. In intermediate-stage vulvar cancer (FIGO III), advanced disease is expressed by affected inguinofemoral lymph nodes bringing radical lymphadenectomy and adjuvant therapy as well as radiation or chemoradiation into the focus of treatment. For locally advanced or metastatic vulvar cancer (FIGO IV) neoadjuvant or definitive chemoradiation has to be considered besides surgery. Owing to the low incidence of the disease, the level of evidence for different treatment modalities is poor. This review therefore puts different recommendations of clinical management in context and highlights the need for future trials.

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Section: Recommendations For Radiotherapy In Intermediate-stage Vulvamentioning

confidence: 99%

Management of patients with vulvar cancer: a perspective review according to tumour stage

et al. 2013

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“…However, to date, the preferred treatment for this condition is surgical and the most important clinical prognostic factor in vulvar cancer is the lymph node status (12,13). Little is known about prognostic factors that may indeed provide a better psychosocial quality of life for the women diagnosed with vulvar cancer.…”

Section: Introductionmentioning

confidence: 99%

microRNA Portraits in Human Vulvar Carcinoma

Maia

Lavorato-Rocha

Rodrigues

et al. 2013

Cancer Prevention Research

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Unregulated expression of microRNAs is well known and has already been demonstrated in many tumor types. However, in vulvar carcinoma this field has been unknown territory. Our study characterizes microRNA in vulvar tumors through an expression profile of 754 miRNAs, relating this with clinical and anatomopathologic data, and presence of HPV infection. Twenty HPV-negative and 20 HPV-positive samples, genotyped for high-risk HPVs (HPV16, 18, 31, 33) and a pool of seven normal vulvar skin samples were used for the identification of differentially expressed miRNAs by TLDA Quantitative Real Time PCR (qRT-PCR). Twenty-five differentially expressed microRNAs between HPV-positive and HPV-negative groups and 79 differentially expressed on the tumor compared with normal samples were obtained. A network between microRNA expression profiles and putative target mRNAs predicted by target prediction algorithms and previously demonstrated as relevant in vulvar carcinomas, such as TP53, RB, PTEN, and EGFR was constructed. Downregulation of both miR-223-5p and miR-19-b1-5p were correlated with the presence of lymph node metastasis; downregulation of miR-100-3p and miR-19-b1-5p were correlated with presence of vascular invasion; overexpression of miR-519b and miR-133a were associated with advanced FIGO staging. In conclusion, our study demonstrates that microRNAs may be clinically important in vulvar carcinomas and our findings may help for further studies on functional implications of miRNA deregulation in this type of cancer. Cancer Prev Res; 6(11); 1231-41. Ó2013 AACR.

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“…An important improvement in vulvar cancer treatment was the introduction of sentinel node dissection in selected patients with early stage disease [5]. Adjuvant radiotherapy is indicated in patients with lymph node metastases [6], and chemoradiation is a possibility for (locally) advanced vulvar carcinoma [7].…”

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confidence: 99%