Surgery for chronic pancreatitis in children offers considerable pain relief: a tertiary center experience

Abstract

test, p < 0.05). Mitochondrial inhibitors did not significantly reduce Ca2+ clearance. A combination of glycolytic and mitochondrial inhibitors reduces Ca2+ clearance by 49.3% (p < 0.05). 3-BP and iodoacetate also reduced ATP levels to 0.82% and 75.0% of normal (T-test, p < 0.05), whereas there was no significant reduction when treated with mitochondrial inhibitors. 3-BP at a concentration of 300mM increases the rate of Panc-1 cell necrosis measured at 3 h and 6 h (p < 0.01), suggesting a timedependent and dose-dependent response. CCCP has no effect on cell necrosis. Conclusions: Our data suggests inhibition of glycolytic ATP to PMCA is an effective therapeutic target that could represent a new strategy for selectively killing PDAC cells and sparing normal, healthy cells.

Modified Puestow Procedure for Chronic Pancreatitis in an Adolescent Female

“…Postoperative complications and the need for re-operation are relatively common in the surgical management of chronic pancreatitis in children. Complications reported include wound infection, hemorrhage, postoperative pancreatic fistula, bowel obstruction, splenic infarction, and recurrent pancreatitis [ 17 ]. Repeat surgery is most often indicated for recurrent pancreatitis [ 2 ].…”