Surgery for Gastrointestinal Stromal Tumors of the Duodenum

Tien, Yu‐Wen; Lee, Chih-Yuan; Huang, Chun‐Chieh; Hu, Rey‐Heng; Lee, Po‐Huang

doi:10.1245/s10434-009-0761-5

Cited by 65 publications

(73 citation statements)

References 21 publications

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“…Similar survival rates have been reported for patients treated with pancreatico-duodenectomy and simple resection [13]. Therefore, simple resection with negative margins should be the preferred treatment, when possible [15].…”

Section: Discussionsupporting

confidence: 67%

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Duodenal Stromal Tumor: A Rare Cause of Upper Gastrointestinal Bleeding

Dumlu¹,

Özdedeoğlu²,

Bozkurt³

et al. 2013

JCR

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Abstract:Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. Surgery is the primary choice for GIST treatment. However, there is no consensus on the best primary treatment for duodenal stromal tumors. In this study, we discuss the surgical treatment options for duodenal stromal tumors and the clinical outcomes of these treatments with this sample case.

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Section: Discussionsupporting

confidence: 67%

“…However, there is no certain consensus on treatment of tumors located in the duodenum. There are different opinions about the respective benefits of pancreatico-duodenectomy and wedge resection [13].…”

Section: Discussionmentioning

confidence: 99%

Duodenal Stromal Tumor: A Rare Cause of Upper Gastrointestinal Bleeding

Dumlu¹,

Özdedeoğlu²,

Bozkurt³

et al. 2013

JCR

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“…Studies illustrated that compared to the LR group, no statistical significance in disease recurrence was found in the PD group [7, 19, 27, 28]. Also, a meta-analysis confirmed that the oncologic outcome of patients with DGIST was more likely to be dependent on tumor biology rather than the type of surgical procedure [6].…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological and Prognostic Features of Surgical Management in Duodenal Gastrointestinal Stromal Tumors

Shi¹,

Huang²,

Wang³

et al. 2017

Dig Surg

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Background and Objectives: The rarity of duodenal gastrointestinal stromal tumors (DGIST) led to only limited data being available on their management and prognosis. We retrospectively analyzed the clinicopathological features, surgical treatments, adjuvant therapy, and prognosis of DGIST. Methods: Sixty-one patients were identified at diagnosis of primary DGIST from February 2005 to December 2015. One hundred twenty six patients with small intestinal gastrointestinal stromal tutors (GIST) were selected as control groups. Survival analyses were calculated using the Kaplan-Meier method. Results: Three- and five-year recurrence/metastasis-free survival rates of patients with DGIST were similar to those of patients with small intestinal GIST (p > 0.05 for all). Out of 61 cases with DGIST, 45 patients were treated with Limited Resection (LR). Sixteen patients were treated with Pancreaticoduodenectomy (PD). The 3- and 5-year recurrence/metastasis-free survival rates of the PD group and LR group were of no significant difference (p > 0.05 for all). Univariate analysis indicated that factors including surgical approaches, mitotic count, size, and risk grades were significantly associated with recurrence/metastasis-free survival (log-rank test, p < 0.05). Multivariate analysis demonstrated that the mitotic count was independently correlated with a worse recurrence/metastasis-free survival. Conclusions: Patients with radical resected DGIST had a favourable prognosis, which is similar to that of small intestinal GIST. Both LR and PD were optimal choices for treating DGIST.

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“…Uehara reports an even higher proportion of 40 % of patients treated by duodenopancreatectomy for duodenal GIST [21]. There have been some large case series reported more recently reiterating the continued dilemma over the surgical treatment of duodenal GISTs [20,22,23]. The literature search that we performed revealed that these lesions can be easily mistaken for an adenocarcinoma and this subsequently leads to treatment with a pancreaticoduodenectomy rather than an organ-sparing procedure.…”

Section: Discussionmentioning

confidence: 99%

A duodenal stromal tumor mimicking a pancreatic head tumor: one case report and literature review

Mouaqit

Ktaibi

et al. 2013

Eur Surg

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Backround Duodenal gastrointestinal stromal tumors are rare tumors. When these tumors arise from the second part of the duodenum they can easily be misdiagnosed as a pancreatic head cancer.Methods Case report and review of the literature. ResultsWe report on a case of a 37-year-old female presenting with a one-year history of right upper quadrant pain associated with palpable abdominal tumor. Computed tomography scans showed a lesion in the head of the pancreas. No endoscopic fine-needle aspiration (FNA) cytology was carried. No specific mucosal abnormalities were reported in the duodenum. Following a roof top incision, a laparotomy was performed with an examination of the pancreas. This revealed a hard mass in the head of the pancreas and dissection in preparation for a pancreaticoduodenectomy was done. Histopathological and immunohistochemical analysis revealed the duodenal gastrointestinal stromal tumor with high-grade malignancy.Conclusions Duodenal gastrointestinal stromal tumor can have a wide spectrum of clinical presentation. The accurate diagnosis of duodenal gastrointestinal stromal tumor is essential for determining the appropriate surgical intervention. In our case, a radical surgical approach was used to avoid passing near an adenocarcinoma.

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Surgery for Gastrointestinal Stromal Tumors of the Duodenum

Abstract: Based on the fact that type of operation was not correlated to operative risk and disease recurrence, limited operation rather than PD should be attempted for duodenal GIST without involvement of papilla of Vater to preserve more pancreas parenchyma, duodenum, and common bile duct.

Cited by 65 publications

References 21 publications

Duodenal Stromal Tumor: A Rare Cause of Upper Gastrointestinal Bleeding

Duodenal Stromal Tumor: A Rare Cause of Upper Gastrointestinal Bleeding

Clinicopathological and Prognostic Features of Surgical Management in Duodenal Gastrointestinal Stromal Tumors

A duodenal stromal tumor mimicking a pancreatic head tumor: one case report and literature review

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