Surgery for non-small cell lung carcinoma after previous chemoradiotherapy alone

Пикин, О. В.; Ryabov, А. B.; Glushko, V. A.; Колбанов, К. И.; Амиралиев, А. М.; Вурсол, Д. А.; Bagrov, V. A.; Бармин, В. В.

doi:10.17116/hirurgia201611228-31

Cited by 2 publications

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“…According to the annual report on the status of cancer in China, in total, 651,053 patients were newly diagnosed with lung cancer in 2011, including 441,364 men and 209,689 women [ 2 ]. Lung and bronchus cancer is usually classified into NSCLC and small cell lung cancer (SCLC) accounting for approximately 80% and 20% respectively, the former of which is traditionally treated with surgery combined with or without radiochemotherapy [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Long non-coding RNAs associated with non-small cell lung cancer

et al. 2017

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Lung cancer, with 80–85% being non-small cell lung cancer (NSCLC), is the leading cause of cancer-related death in both men and women. Long non-coding RNAs (lncRNAs), always defined as non-protein-coding RNA molecules longer than 200 nucleotides, are now thought as a new frontier in the study of human malignant diseases including NSCLC. As researches continue, increasing number of roles that lncRNAs play in NSCLC has been found, and more and more evidences show lncRNAs have a close relationship with patients’ response to radiochemotherapy or molecular therapy. The aim of this review is to disclose the roles that lncRNAs play in NSCLC and how lncRANs influence the treatment of NSCLC.

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Section: Introductionmentioning

confidence: 99%

Long non-coding RNAs associated with non-small cell lung cancer

et al. 2017

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“…Показанием к операции может быть и ликвидация жизнеугрожающих осложнений консервативного противоопухолевого лечения. В таком случае операция называется «операцией спасения» (salvage surgery) [24,46]. Эти операции позволяют рассчитывать на длительную выживаемость, особенно у больных со значимым патологическим ответом [47].…”

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The analysis of current international recommendations for the treatment of patients with stage III non-small cell lung cancer

Akopov

2024

VESTNIK KHIRURGII IMENI I.I.GREKOVA

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The development of systemic antitumor treatment, targeted therapy and immune checkpoint inhibitor therapy (ICI) has changed the treatment outcome and prognosis for locally advanced non-small cell lung cancer (NSCLC). Modern recommendations provide for the division of such patients into potentially resectable and unresectable, and such division does not always correspond to stage IIIa, IIIb or IIIc of the disease. The treatment of resectable tumors is recommended to start with neoadjuvant chemoimmunotherapy (CIT), followed by surgical intervention aimed at radical tumor removal only in patients who respond to treatment. For unresectable tumors, the best approach is considered to be simultaneous chemoradiation therapy (CRT) followed by adjuvant ICI therapy, and the role of surgical interventions is limited to salvage surgery – residual tumor or local relapse removal after non-surgical self-treatment.This approach to the treatment of patients with stage III NSCLC is unlikely to fully satisfy specialists and patients – there is no complete consensus on the definition of the term «resectability»; the possibility of converting an unresect able tumor into a resectable one as a result of neoadjuvant treatment is denied, which is contrary to clinical practice. The objective of the article was the critical analysis of existing recommendations on the role of the surgical approach as a stage of complex treatment of stage III NSCLC from the surgeon’s point of view.

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Surgery for non-small cell lung carcinoma after previous chemoradiotherapy alone

Abstract: «Salvage» surgery may be recommended as individual approach in patients with reccurent lung cancer after previous chemoradiotherapy.

Cited by 2 publications

References 5 publications

Long non-coding RNAs associated with non-small cell lung cancer

Long non-coding RNAs associated with non-small cell lung cancer

The analysis of current international recommendations for the treatment of patients with stage III non-small cell lung cancer

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