Surgery for Pancreatic and Periampullary Carcinoma

Mitra, Abhishek; D’souza, Ashwin; Goel, Mahesh; Shrikhande, Shailesh V.

doi:10.1007/s12262-015-1358-9

Cited by 3 publications

(2 citation statements)

References 92 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…EUS plays an important role in the screening and diagnosis of PDA. EUS was shown to be superior to MDCT, MRI and positron emission tomography (PET) in detecting small lesions and lymph node involvement[ 96 ]. It was able to detect twice the number of lesions compared to MDCT and MRI when used for screening[ 94 ].…”

Section: Recent Advances In Screening and Diagnosismentioning

confidence: 99%

Pancreatic adenocarcinoma: A review of recent paradigms and advances in epidemiology, clinical diagnosis and management

Gupta

Yelamanchi

2021

WJG

View full text Add to dashboard Cite

Pancreatic cancer is one of the dreaded malignancies for both the patient and the clinician. The five-year survival rate of pancreatic adenocarcinoma (PDA) is as low as 2% despite multimodality treatment even in the best hands. As per the Global Cancer Observatory of the International Agency for Research in Cancer estimates of pancreatic cancer, by 2040, a 61.7% increase is expected in the total number of cases globally. With the widespread availability of next-generation sequencing, the entire genome of the tumors is being sequenced regularly, providing insight into their pathogenesis. As invasive PDA arises from pancreatic intraepithelial neoplasia and mucinous neoplasm and intraductal papillary neoplasm, screening for them can be beneficial as the disease is curable with resection at an early stage. Routine preoperative biliary drainage has no role in patients suffering from PDA with obstructive jaundice. If performed, metallic stents are preferred over plastic ones. Minimally invasive procedures are preferred to open procedures as they have less morbidity. The duct-to-mucosa technique for pancreaticojejunostomy is presently widely practiced. The role of intraperitoneal drains after surgery for PDA is controversial. Neoadjuvant chemoradiotherapy has been proven to have a significant role both in locally advanced as well as in resectable PDA. Many new regimens and drugs have been added in the arsenal of chemoradiotherapy for metastatic disease. The roles of immunotherapy and gene therapy in PDA are being investigated. This review article is intended to improve the understanding of the readers with respect to the latest updates of PDA, which may help to trigger new research ideas and make better management decisions.

show abstract

Section: Recent Advances In Screening and Diagnosismentioning

confidence: 99%

Pancreatic adenocarcinoma: A review of recent paradigms and advances in epidemiology, clinical diagnosis and management

Gupta

Yelamanchi

2021

WJG

View full text Add to dashboard Cite

show abstract

“…Positron emission tomography (PET) scan can help identify patients with metastatic disease. Due to its low specificity, a PET scan is not helpful to identify tumor size, invasion, and nodal staging [26,27]. The T staging is better assessed by the MDCT [28].…”

Section: Introductionmentioning

confidence: 99%

The Role of Endoscopic Ultrasonography in the Diagnosis and Staging of Pancreatic Cancer

Zakaria

Al-Share

Klapman

et al. 2022

Cancers

View full text Add to dashboard Cite

Pancreatic cancer is the fourth leading cause of cancer-related death and the second gastrointestinal cancer-related death in the United States. Early detection and accurate diagnosis and staging of pancreatic cancer are paramount in guiding treatment plans, as surgical resection can provide the only potential cure for this disease. The overall prognosis of pancreatic cancer is poor even in patients with resectable disease. The 5-year survival after surgical resection is ~10% in node-positive disease compared to ~30% in node-negative disease. The advancement of imaging studies and the multidisciplinary approach involving radiologists, gastroenterologists, advanced endoscopists, medical, radiation, and surgical oncologists have a major impact on the management of pancreatic cancer. Endoscopic ultrasonography is essential in the diagnosis by obtaining tissue (FNA or FNB) and in the loco-regional staging of the disease. The advancement in EUS techniques has made this modality a critical adjunct in the management process of pancreatic cancer. In this review article, we provide an overall description of the role of endoscopic ultrasonography in the diagnosis and staging of pancreatic cancer.

show abstract

Adjuvant therapy may improve overall survival in high-risk periampullary adenocarcinomas patients – A match-pair analysis from a multi-institutional cohort study (The MIPPAP study)

Ramaswamy,

Chaudhari,

Srinivas

et al. 2024

HPB

View full text Add to dashboard Cite

Surgery for Pancreatic and Periampullary Carcinoma

Cited by 3 publications

References 92 publications

Pancreatic adenocarcinoma: A review of recent paradigms and advances in epidemiology, clinical diagnosis and management

Pancreatic adenocarcinoma: A review of recent paradigms and advances in epidemiology, clinical diagnosis and management

The Role of Endoscopic Ultrasonography in the Diagnosis and Staging of Pancreatic Cancer

Adjuvant therapy may improve overall survival in high-risk periampullary adenocarcinomas patients – A match-pair analysis from a multi-institutional cohort study (The MIPPAP study)

Contact Info

Product

Resources

About