Background
Cataract formation or acceleration can occur after intraocular
surgery, especially following vitrectomy, a surgical technique for removing
the vitreous which is used in the treatment of disorders that affect the
posterior segment of the eye. The underlying problem that led to vitrectomy
may limit the benefit from cataract surgery.
Objectives
The objective of this review was to evaluate the effectiveness and
safety of surgery for post-vitrectomy cataract with respect to visual
acuity, quality of life, and other outcomes.
Search methods
We searched CENTRAL (which contains the Cochrane Eyes and Vision
Group Trials Register) (The Cochrane Library 2013, Issue
4), Ovid MEDLINE, Ovid MEDLINE in-Process and Other Non-Indexed Citations,
Ovid MEDLINE Daily Update, Ovid OLDMED-LINE (January 1946 to May 2013),
EMBASE (January 1980 to May 2013, Latin American and Caribbean Health
Sciences Literature Database (LILACS) (January 1982 to May 2013), PubMed
(January 1946 to May 2013), the metaRegister of Controlled
Trials (mRCT) (www.controlled-trials.com), ClinicalTrials.gov (www.clinicaltrial.gov) and the WHO International Clinical
Trials Registry Platform (ICTRP) (www.who.int/ictrp/search/en). We did not use any date or
language restrictions in the electronic searches for trials. We last
searched the electronic databases on 22 May 2013.
Selection criteria
We planned to include randomized and quasi-randomized controlled
trials comparing cataract surgery with no surgery in adult patients who
developed cataract following vitrectomy.
Data collection and analysis
Two authors screened the search results independently according to
the standard methodological procedures expected by The Cochrane
Collaboration.
Main results
We found no randomized or quasi-randomized controlled trials
comparing cataract surgery with no cataract surgery for patients who
developed cataracts following vitrectomy surgery.
Authors' conclusions
There is no evidence from randomized or quasi-randomized controlled
trials on which to base clinical recommendations for surgery for
post-vitrectomy cataract. There is a clear need for randomized controlled
trials to address this evidence gap. Such trials should stratify
participants by their age, the retinal disorder leading to vitrectomy, and
the status of the underlying disease process in the contralateral eye.
Outcomes assessed in such trials may include gain of vision on the Early
Treatment Diabetic Retinopathy Study (ETDRS) scale, quality of life, and
adverse events such as posterior capsular rupture. Both short-term
(six-month) and long-term (one-year or two-year) outcomes should be
examined.