Surgery Improve the Prognosis of Colon Mucinous Adenocarcinoma with Liver Metastases: A SEER-Based Study

Abstract

Background Mucinous adenocarcinoma (MAC) is the second common pathological type of colon carcinoma (CC). Colon cancer liver metastases (CLM) is common and lethal, complete resection for both of the primary tumor and metastases of CLM would be beneficial. However, there is still no consensus for the role of surgery in MAC of CC with liver metastases (M-CLM).Methods Among 5816 patients who diagnosed with M-CLM or classical adenocarcinoma of CLM (A-CLM) from 2010 to 2013 in the Surveillance, Epidemiology, and End Results (SEER) database were retrieved. The clinicopathological features and overall survival (OS) and cancer-specific survival (CSS) data were compared and analyzed.Results Total of 5816 M-CLM and A-CLM patients were enrolled in this study. Results showed M-CLM group had larger tumor size, more right colon location, high pT and pN stage compared with A-CLM group, as well as more female patients, more examined and positive lymph nodes and a higher proportion of surgery than A-CLM group. The OS and CSS of M-CLM patients accepted any surgery were significantly better than that didn’t accept any surgery, but poorer than that of A-CLM patients. Meanwhile, the OS and CSS of M-CLM and A-CLM were comparable when they didn’t receive any surgery. Moreover, partial colectomy provided the similar OS and CSS compared with hemicolectomy or greater for M-CLM, and surgery was an independent protective factor for long-term survival of M-CLM.Conclusions M-CLM had distinct clinicopathological characteristics, surgery could improve the long-term survival and act as an independent protective prognostic factor for M-CLM, additionally, partial colectomy might be a better selection for M-CLM from this study.