Surgery in Advanced Disease (Testicular Cancer)

Donohue, John P.; Koops, H. Schraffordt; Hendry, W F; Debruyne, F. M. J.

doi:10.1159/000419209

Cited by 2 publications

(1 citation statement)

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“…[4][5][6] The extent of surgery is also debatable; some excise only visible abnormal masses, 7 whereas others perform a more extensive retroperitoneal lymph nodes dissection. 8 Pathology of resected masses may reveal necrosis/fibrosis, mature teratoma, or cancer and additional chemotherapy is usually given to kill the remaining microscopic disease when viable cancer cells are present in the resected specimens. 3,9 In general, it has been suggested that the type of additional chemotherapy should preferably be a salvage regimen different from initial chemotherapy.…”

Section: Introductionmentioning

confidence: 99%

The significance of resections for residual masses after chemotherapy in metastatic testicular tumors

et al. 1999

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Background: After chemotherapy for metastatic testicular tumors, masses may remain, often in the metastatic sites. This study analyses the role of resections for the residual masses. Conclusions:Resection for residual masses after chemotherapy in metastatic testicular tumors was useful in confirming the tissue and in controlling the metastatic sites. Recurrences were often found in patients with cancer in the residual mass and the prognosis of patients with cancer was poor, therefore the development of more effective therapy for patients with cancer is required to improve the prognosis.

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Section: Introductionmentioning

confidence: 99%

The significance of resections for residual masses after chemotherapy in metastatic testicular tumors

et al. 1999

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Prediction of residual retroperitoneal mass histology after chemotherapy for metastatic nonseminomatous germ cell tumor: multivariate analysis of individual patient data from six study groups.

Steyerberg

Keizer²,

Fosså³

et al. 1995

JCO

242

146

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Purpose:To develop a statistical model that predicts the histology (necrosis, mature teratoma, or cancer) after chemotherapy for metastatic nonseminomatous germ cell tumor (NSGCT).Patients and Methods: An international data set was collected comprising individual patient data from six study groups. Logistic regression analysis was used to estimate the probability of necrosis and the ratio of cancer and mature teratoma.Results: Of 556 patients, 250 (45%) had necrosis at resection, 236 (42%) had mature teratoma, and 70 (13%) had cancer. Predictors of necrosis were the absence of teratoma elements in the primary tumor, prechemotherapy normal alfa-fetoprotein (AFP), normal human chorionic gonadotropin (HCG), and elevated lactate dehydrogenase (LDH) levels, a small prechemotherapy or postchemotherapy mass, and a large shrinkage of the

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Surgery in Advanced Disease (Testicular Cancer)

Cited by 2 publications

References 0 publications

The significance of resections for residual masses after chemotherapy in metastatic testicular tumors

The significance of resections for residual masses after chemotherapy in metastatic testicular tumors

Prediction of residual retroperitoneal mass histology after chemotherapy for metastatic nonseminomatous germ cell tumor: multivariate analysis of individual patient data from six study groups.

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