Surgery in cerebral metastases: Are numbers so important?

Agnoletti, Alessandro; Mencarani, Camilla; Panciani, Pier Paolo; Buffoni, L; Ronchetti, Gabriele; Spena, Giannantonio; Tartara, Fulvio; Buglione, Michela; Pagano, Manuela; Ducati, Alessandro; Fontanella, Marco Maria; Garbossa, Diego

doi:10.4103/0973-1482.131390

Cited by 30 publications

(3 citation statements)

References 28 publications

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“…[ 12 – 14 ] Sodium cantharidinate/vitamin B6 (SC/VB6, a famous insect-derived traditional Chinese medicine) is a combination of sodium cantharidinate and VB6, and has the pharmacological characteristics of both. [ 11 , 15 , 16 ] SC is a derivative of cantharidin, which is extracted from the body of meloidae insects such as Mylabris phalerata pallas and Mylabris cichorii linnaeus . [ 11 , 17 ] SC preserves the unique anti-cancer activity of cantharidin and has lower toxicity and fewer adverse effects.…”

Section: Introductionmentioning

confidence: 99%

“…[ 11 , 17 ] SC preserves the unique anti-cancer activity of cantharidin and has lower toxicity and fewer adverse effects. [ 11 , 15 , 17 ] Its combination with VB6 can even further lower the side effects. [ 11 , 15 ] Previous studies suggest that the anti-tumor mechanisms of SC might be attributed to the following aspects:…”

Section: Introductionmentioning

confidence: 99%

“…[ 11 , 15 , 17 ] Its combination with VB6 can even further lower the side effects. [ 11 , 15 ] Previous studies suggest that the anti-tumor mechanisms of SC might be attributed to the following aspects:…”

Section: Introductionmentioning

confidence: 99%

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Effect of sodium cantharidinate/vitamin B6 injection on survival, liver function, immune function, and quality of life in patients with hepatocellular carcinoma

Zhu¹,

Liu²,

Zhou

et al. 2020

Medicine

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Background: Sodium cantharidinate/vitamin B6 (SC/VB6) injection, a famous insect-derived traditional Chinese medicine preparation, has been widely applied as a promising adjunctive drug for hepatocellular carcinoma (HCC). However, its exact clinical efficacy and safety is still not well investigated. In this study, we aimed to summarize the efficacy of SC/VB6 injection on survival, liver function, immune function, and quality of life (QoL) in patients with HCC through the meta-analysis. Methods: All available randomized controlled trials (RCTs) and high-quality prospective cohort studies that investigated the efficacy and safety of SC/VB6 for patients with HCC were searched from ten electronic databases including PubMed, Google Scholar, Cochrane Library, Excerpt Medica Database (Embase), Medline, Web of Science (WOS), Chinese Biomedical Literature Database (CBM), China National Knowledge Infrastructure (CNKI), China Scientific Journal Database (CSJ), and Wanfang Database. Papers in Chinese or English published from January 2000 to July 2020 will be included without any restrictions. Study selection and data extraction will be performed independently by 2 researchers. The clinical outcomes including overall survival (OS), QoL, liver function, immune function, and adverse events, were systematically evaluated. Review Manager 5.3 and Stata 14.0 were used for data analysis, and the quality of the clinical trials was also evaluated. Results: The results of this study will be published in a peer-reviewed journal, and provide a helpful evidence for clinicians to formulate the best postoperative adjuvant treatment strategy for HCC patients. Conclusion: Our study will draw an objective conclusion of the efficacy of SC/VB6 on survival, liver function, immune function, and QoL in patients with HCC. INPLASY registration number: INPLASY202070121.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of sodium cantharidinate/vitamin B6 injection on survival, liver function, immune function, and quality of life in patients with hepatocellular carcinoma

Zhu¹,

Liu²,

Zhou

et al. 2020

Medicine

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Neurosurgical resection of multiple brain metastases: outcomes, complications, and survival rates in a retrospective analysis

Niedermeyer,

Schmutzer-Sondergeld,

Weller

et al. 2024

J Neurooncol

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Purpose This study investigates the outcomes of microsurgical resection of multiple brain metastasis (BMs). Methods This retrospective, monocentric analysis included clinical data from all consecutive BM patients, who underwent simultaneous resection of ≥ 2 BMs between January 2018 and May 2023. Postoperative neurological and functional outcomes, along with perioperative complications, as well as survival data were evaluated. Results A total of 47 patients, with a median age of 61 years (IQR 48–69), underwent 73 craniotomies (median 2; range 1–3) for resection of 104 BMs. Among patients, 80.8% presented with symptomatic BMs, causing focal neurological deficits in 53% of cases. Gross total resection was achieved in 87.2% of BMs. Karnofsky Performance Scale (KPS) scores improved in 42.6% of patients, remained unchanged in 46.8%, and worsened in 10.6% after surgery. Perioperative complications were observed in 29.8% of cases, with transient complications occurring in 19.2% and permanent deficits in 10.6%. The 30-days mortality rate was 2.1%. Logistic regression identified eloquent localization (p = 0.036) and infratentorial craniotomy (p = 0.018) as significant predictors of postoperative complications. Concerning overall prognosis, patients with permanent neurological deficits post-surgery (HR 11.34, p = 0.007) or progressive extracranial disease (HR: 4.649; p = 0.006) exhibited inferior survival. Conclusion Microsurgical resection of multiple BMs leads to clinical stabilization or functional improvement in most patients. Although transient complications do not affect overall survival, the presence of persistent neurological deficits (> 3 months post-surgery) and progressive extracranial disease negatively impact overall survival. This highlights the importance of careful patient selection for resection of multiple BMs.

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The treatment of patients with 1–3 brain metastases: is there a place for whole brain radiotherapy alone, yet? A retrospective analysis

et al. 2015

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Surgery in cerebral metastases: Are numbers so important?

Cited by 30 publications

References 28 publications

Effect of sodium cantharidinate/vitamin B6 injection on survival, liver function, immune function, and quality of life in patients with hepatocellular carcinoma

Effect of sodium cantharidinate/vitamin B6 injection on survival, liver function, immune function, and quality of life in patients with hepatocellular carcinoma

Neurosurgical resection of multiple brain metastases: outcomes, complications, and survival rates in a retrospective analysis

The treatment of patients with 1–3 brain metastases: is there a place for whole brain radiotherapy alone, yet? A retrospective analysis

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