Surgery of Liver Tumors in Children in the Last 15 Years

Andrés, Ane Miren; Hernandez, Francisco; López‐Santamaría, Manuel; Gámez, M; Murcia, J; Leal, Ney Fuhrmann; Gutierrez, Juan C.; Sastre, A; Tovar, Juan A.

doi:10.1055/s-2007-989270

Cited by 8 publications

(6 citation statements)

References 21 publications

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“…Still [7,11,12,27] . Postnatally, laparotomy offers definitive diagnosis and treatment [1,28,29] . A transverse upper abdominal incision usually enables sufficient exposure.…”

Section: Discussionmentioning

confidence: 99%

Mesenchymal Hamartoma of the Liver: A Benign Tumor with Deceptive Prognosis in the Perinatal Period

Cornette¹,

Festen

Hoonaard

et al. 2009

Fetal Diagn Ther

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This article reports a case of perinatal mesenchymal hepatic hamartoma and reviews the literature on the subject. A fetus presented with polyhydramnios and a large multiloculated cystic abdominal mass at 33 weeks of gestation. The ultrasound appearance was most consistent with a mesenteric cyst. Prenatal drainage was considered, due to the size of the lesion. However, a conservative management was opted for. A female infant was born at 35 weeks by classical cesarean section. The immediate postnatal period was characterized by hemodynamic instability. Laparotomy revealed a pedunculated mesenchymal hamartoma of the liver, which could not completely be resected. The infant had an uneventful postoperative recovery and is doing well at 6 months of age. Hepatic mesenchymal hamartoma are rare benign tumors. Most cases are detected in early childhood. They usually present as a cystic rapidly growing abdominal mass. Prenatal diagnosis remains challenging. In children diagnosed in the perinatal period, the outcome seems worse and determined by the compressive effect of the mass.

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“…Still [7,11,12,27] . Postnatally, laparotomy offers definitive diagnosis and treatment [1,28,29] . A transverse upper abdominal incision usually enables sufficient exposure.…”

Section: Discussionmentioning

confidence: 99%

Mesenchymal Hamartoma of the Liver: A Benign Tumor with Deceptive Prognosis in the Perinatal Period

Cornette¹,

Festen

Hoonaard

et al. 2009

Fetal Diagn Ther

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“…Since 2004, the standard recommended treatment of PRETEXT IV HB without extrahepatic involvement is total hepatectomy and liver transplantation [15,16,[24][25][26][27][28][29]. This recommendation is based on several recent data showing that (1) this treatment provides children with a 5-year disease-free survival rate ranging between 69% and 89% [15,28,30], and this survival rate compares favorably with some nononcological indications for pediatric liver transplantation, such as fulminant hepatic failure [12,14].…”

Section: Discussionmentioning

confidence: 99%

Cure of multifocal panhepatic hepatoblastoma: is liver transplantation always necessary?

Baertschiger

Özşahin

Rougemont

et al. 2010

Journal of Pediatric Surgery

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“…Two-thirds of liver tumours in children are malignant, with hepatoblastoma (HB) being the most frequent (50-60%), followed by hepatocellular carcinoma (HCC) (25-30%) and undifferentiated sarcoma (5-7%) ( 2 ). All the others, including malignant vascular tumours, are extremely rare and account for about 3-5% of all pediatric liver malignancies ( 1 , 3 ). On the other hand, benign primary liver tumours such as vascular tumours, hamartoma, adenoma and focal nodular hyperplasia, represent less than 30% of primary hepatic tumours in children ( 1 , 4 ).…”

Section: Introductionmentioning

confidence: 99%

“…With the implementation of new chemotherapy regimens and the development of a multi-specialist approach in recent decades (multimodal sequential or combined approach with chemotherapy, interventional radiology and surgery, including liver transplantation in selected cases), impressive progress has been achieved. In contrast, the role of liver transplantation has become pivotal for offering a chance of resection in selected patients with otherwise unresectable tumours ( 1 , 3 ).…”

Section: Introductionmentioning

confidence: 99%

The role of liver transplantation in the care of primary hepatic vascular tumours in children

et al. 2022

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Liver transplantation (LT) is the standard of care for many liver conditions, such as end-stage liver diseases, inherited metabolic disorders, and primary liver malignancies. In the latter group, indications of LT for hepatoblastoma and hepatocellular carcinoma evolved and are currently available for many non-resectable cases. However, selection criteria apply, as the absence of active metastases. Evidence of good long-term outcomes has validated the LT approach for managing these malignancies in the context of specialist and multidisciplinary approach. Nevertheless, LT’s role in treating primary vascular tumours of the liver in children, both benign and malignant, remains somewhat controversial. The rarity of the different diseases and the heterogeneity of pathological definitions contribute to the controversy and make evaluating the benefit/risk ratio and outcomes quite difficult. In this narrative review, we give an overview of primary vascular tumours of the liver in children, the possible indications and the outcomes of LT.

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Surgery of Liver Tumors in Children in the Last 15 Years

Abstract: Outcomes have improved much in the last years. Surgical removal is necessary in most cases. Transplantation is a very useful adjunct. Treatment of these tumors should be concentrated in centers with expertise.

Cited by 8 publications

References 21 publications

Mesenchymal Hamartoma of the Liver: A Benign Tumor with Deceptive Prognosis in the Perinatal Period

Mesenchymal Hamartoma of the Liver: A Benign Tumor with Deceptive Prognosis in the Perinatal Period

Cure of multifocal panhepatic hepatoblastoma: is liver transplantation always necessary?

The role of liver transplantation in the care of primary hepatic vascular tumours in children

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