Surgical adhesive: Synthesis and properties of thermoresponsive Pluronic L‐31–3,4–dihydroxyphenylalanine–arginine derivatives

Abstract

A novel thermosensitive adhesive was synthesized by the esterification reaction of multihydroxyl Pluronic L-31 with 3,4dihydroxy-L-phenylalanine and L-arginine. Pluronic L-31-DOPA-arginine derivative (PDA) gels, rapidly formed in situ with horseradish peroxidase and hydrogen peroxide, were used to explore the performance of efficient tissue adhesives. The results of their adhesive strength on porcine skin demonstrate that the structure of the polymers and temperature influenced the adhesiveness to tissue of the polymers. Compared with the PDAs at 25 8C, the PDAs at 37 8C showed superior adhesive strength. The attractive performance of the PDA gels were demonstrated by this study's results, which suggest biomedical applications in tissue-adhesive devices in the future.

Effect of Hydrophobic Polypeptide Length on Performances of Thermo-Sensitive Hydrogels

“…On the one hand, they are rather safe for clinical utilization because the common thermosensitive gel preparation process does not involve the use of organic solvents. On the other hand, the gelling conditions of heat-sensitive hydrogels are easy to control, making them applicable in the field of biomedicine [ 10 , 11 , 12 ].…”