Surgical and oncological outcomes after complete mesocolic excision in right-sided colon cancer compared with conventional surgery: a retrospective, single-institution study

Zurleni, Tommaso; Cassiano, A.; Gjoni, Elson; Ballabio, Andrea; Serio, Giovanni; Marzoli, L.; Zurleni, F.

doi:10.1007/s00384-017-2917-2

Cited by 40 publications

(49 citation statements)

References 45 publications

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“…Laparoscopic colorectal cancer surgery, which has an obvious minimally invasive advantage in the abdominal cavity, has become one of the most established surgical methods used for gastrointestinal cancer surgery [15,16] . For the better application of CMEs in laparoscopic hemicolectomies for right colon carcinoma cases, the following points have been summarized in the literature [8,12,17,18] and in our clinical experience. First, a CME presents the concept of fine anatomy.…”

Section: Discussionmentioning

confidence: 99%

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Safety and Short-term Efcacy of a Laparoscopic Complete Mesocolic Excision for the Surgical Treatment of Right Hemicolon Cancer

Li¹,

Meng²,

Chen³

2018

Clin Surg Res Commun

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Objective: This study was designed to evaluate the safety and short-term efficacy of a laparoscopic complete mesocolic excision (CME) in patients with right hemicolon cancer. Methods: A total of 88 patients with right hemicolon cancer were retrospectively reviewed. Forty patients underwent laparoscopic CMEs, and 48 patients underwent open CMEs. The clinical data were analyzed and the outcomes were compared between the two groups. Result: There was no significant difference between the laparoscopic CME group and open CME group with regard to the harvested lymph node number (16.60±3.20 vs. 15.33±3.10, respectively, P=0.060), hospital stay length (18.15±5.17 days vs. 17.21±4.47 days, respectively, P=0.360), and postoperative complications (10.0% vs. 10.4%, respectively, P=0.950). The operation time in the laparoscopic CME group (3.02±0.55 hours) was significantly longer than that in the open CME group (2.58±0.50 hours, P=0.004). The time to first flatus (3.28±0.75 days vs 3.92±0.71 days, respectively, P=0.001) and getting out of bed time (1.95±0.75 days vs 3.54±0.71 days, respectively, P=0.001) were both earlier in the laparoscopic CME group than in the open CME group. Conclusion: A laparoscopic CME is a safe and effective minimally invasive surgery for the treatment of right hemicolon cancer.

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Section: Discussionmentioning

confidence: 99%

“…lon cancer have improved over the last decade [5,6] . Increasing evidence has reported that CMEs contribute to a decreased recurrence rate and increased five-year survival [4,7,8] . At present, a CME is considered to be the standard surgical method for treating colon cancer.…”

mentioning

confidence: 99%

Safety and Short-term Efcacy of a Laparoscopic Complete Mesocolic Excision for the Surgical Treatment of Right Hemicolon Cancer

Li¹,

Meng²,

Chen³

2018

Clin Surg Res Commun

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“…Around 19% of the patients had complications grade III-IV. The literature reports complication rates or postoperative morbidity rates associated with CME surgery from 19% to 35% (8,(10)(11)(12)(13)(14)(15). Reviews published for the last few years to evaluate the safety, quality, and effect of CME discuss the different ways of reporting complications and thus making comparisons difficult (16)(17)(18)(19)(20).…”

Section: Discussionmentioning

confidence: 99%

Risk Factors for Complications following Introduction of Radical Surgery for Colon Cancer: A Consecutive Patient Series

et al. 2018

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“…CSS was significantly improved in RCC patients with a minimum of 15 LNs examined, but the minimum requirement for better CSS could be reduced down to 11 LNs LCC patients 30 . Moreover, it has been suggested that postoperative survival rates of RCC and LCC patients may be affected by surgical treatment 31 . Therefore, the present study aimed to explore the prognostic impacts of the number of LNs examined and LN ratio in RCC and LCC patients, especially if patients undergoing different surgical treatments or at distinct cancer stages.…”

Section: Introductionmentioning

confidence: 99%

Tumor sidedness influences prognostic impact of lymph node metastasis in colon cancer patients undergoing curative surgery

Lai

Wei

Hung

et al. 2019

Sci Rep

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This study aimed to evaluate prognostic impacts of the number of lymph nodes (LNs) examined and LN ratio on cancer-specific mortality after surgery in patients with right-sided colon cancer (RCC) or left-sided colon cancer (LCC) using the Surveillance, Epidemiology, and End Results database. Number of LNs examined and LN ratio were treated as categorical and/or continuous. Competing risks proportional hazards regressions adjusted by propensity score were performed. All included patients had stage I, II, or III disease, and 45.1% of them had RCC. RCC and LCC patients with high level of LNs examined had better prognosis after segmental resection or hemicolectomy. RCC and LCC patients with higher LN ratio had worse prognosis regardless of surgery. Survival benefit of having high level of LNs examined was observed in RCC patients with stage I, II, or III disease, but only in LCC patients with stage II disease. Both higher LN ratio and high level of LN were negative prognostic factors for cancer-specific mortality in stage III patients regardless of tumor sidedness. In conclusion, RCC patients in various conditions had worse or comparable prognosis compared to their LCC counterparts, which reflected the severity of LN metastasis.

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Surgical and oncological outcomes after complete mesocolic excision in right-sided colon cancer compared with conventional surgery: a retrospective, single-institution study

Abstract: Surgical standardization of CME with CVL for right-sided colon cancer is associated with better staging and prognosis, particularly in UICC stage II and III. This study shows that CME is safe and reproducible with acceptable morbidity.

Cited by 40 publications

References 45 publications

Safety and Short-term Efcacy of a Laparoscopic Complete Mesocolic Excision for the Surgical Treatment of Right Hemicolon Cancer

Safety and Short-term Efcacy of a Laparoscopic Complete Mesocolic Excision for the Surgical Treatment of Right Hemicolon Cancer

Risk Factors for Complications following Introduction of Radical Surgery for Colon Cancer: A Consecutive Patient Series

Tumor sidedness influences prognostic impact of lymph node metastasis in colon cancer patients undergoing curative surgery

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