Surgical approach to microwave and radiofrequency liver ablation for hepatocellular carcinoma and colorectal liver metastases less than 5 cm: a systematic review and meta-analysis

Abdalla, Moustafa; Collings, Amelia T.; Dirks, Rebecca; Onkendi, Edwin; Nelson, Daniel W.; Ozair, Ahmad; Miraflor, Emily; Rahman, Faique; Whiteside, Jake; Shah, Mihir M.; Ayloo, Subhashini; Abou‐Setta, Ahmed M; Sucandy, Iswanto; Kchaou, Ali; Douglas, Samuel; Polanco, Patricio M.; Vreeland, Timothy J.; Buell, Joseph F.; Ansari, Mohammed; Pryor, Aurora D.; Slater, Bethany J.; Awad, Ziad T.; Richardson, William; Jeyarajah, D. Rohan; Ceppa, Eugene P.

doi:10.1007/s00464-022-09815-5

Cited by 16 publications

(3 citation statements)

References 32 publications

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“…2,3 MWA and radiofrequency ablation (RFA) provide similar RFS and OS for patients with HCC 4 or liver metastases. 5 We agree with the authors that not all patients with early disease are 'ideal candidates' for ablation. Similarly, it is also important to determine the best approach for patients with recurrent HCC within Milan criteria.…”

Section: Letter: Repeat Hepatic Resection Versus Radiofrequency Ablat...supporting

confidence: 65%

Letter: repeat hepatic resection versus radiofrequency ablation for recurrent hepatocellular carcinoma in ideal candidates

Teng

zhang

Chan

et al. 2023

Aliment Pharmacol Ther

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Section: Letter: Repeat Hepatic Resection Versus Radiofrequency Ablat...supporting

confidence: 65%

Letter: repeat hepatic resection versus radiofrequency ablation for recurrent hepatocellular carcinoma in ideal candidates

Teng

zhang

Chan

et al. 2023

Aliment Pharmacol Ther

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“…Percutaneous microwave ablation has emerged as a signi cant approach for managing malignant liver tumors [20,21,22,23]. This study's nding of a 70.3% 3-year disease-free survival rate postpercutaneous microwave ablation highlights a signi cant improvement over previous research.…”

Section: Discussionmentioning

confidence: 74%

Enhancing Patient Outcomes through Microwave Ablation in Hepatic Malignant Tumors: Insights on Recurrence Factors

Shi,

Jiang,

et al. 2024

Preprint

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The treatment of hepatic malignant tumors poses a significant global health challenge, often managed through percutaneous microwave ablation (MWA). Understanding the effectiveness of MWA and the factors influencing tumor recurrence is essential for improving patient outcomes. Methods: In this study, a cohort of 101 patients out of 249 with hepatic malignant tumors treated at the Shandong Cancer Hospital and Institute were analyzed. The study evaluated disease-free and overall survival rates at 1, 2, and 3 years post-MWA, exploring correlations between tumor recurrence and variables such as Child-Pugh B liver function classification and lesion count. Additionally, a meta-analysis was conducted to identify independent risk factors for recurrence following MWA treatment. Results: Disease-free survival rates of 80.2%, 72.3%, and 70.3% at 1, 2, and 3 years post-MWA were observed, alongside overall survival rates of 99%, 97%, and 96%. Noteworthy associations were found between tumor recurrence and Child-Pugh B classification, as well as the number of lesions. The meta-analysis further supported lesion count and Child-Pugh B classification as independent risk factors for recurrence post-MWA. Conclusion: Child-Pugh B classification and lesion count emerge as pivotal factors in predicting tumor recurrence post-MWA treatment for hepatic malignant tumors. These insights offer valuable guidance to clinicians in treatment decisions and post-treatment monitoring strategies, potentially leading to improved patient care and outcomes.

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“…Both are based on the local generation of electromagnetic waves but working at different frequencies, 400-500 kHz for the RF and 900-2500 MHz for the MW. The benefits of these techniques are similar in terms of overall survival, complete ablation, recurrence-free survival and local tumor progression [21][22][23][24][25][26]. Potential complications such as bleeding, colon perforation, bile duct stenosis or hemothorax [16,27] are also the same.…”

Section: Introductionmentioning

confidence: 99%

In Vivo Thermal Ablation of Deep Intrahepatic Targets Using a Super-Convergent MRgHIFU Applicator and a Pseudo-Tumor Model

Lorton

Peloso

et al. 2023

Cancers

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Background: HIFU ablation of liver malignancies is particularly challenging due to respiratory motion, high tissue perfusion and the presence of the rib cage. Based on our previous development of a super-convergent phased-array transducer, we aimed to further investigate, in vivo, its applicability to deep intrahepatic targets. Methods: In a series of six pigs, a pseudo-tumor model was used as target, visible both on intra-operatory MRI and post-mortem gross pathology. The transcostal MRgHIFU ablation was prescribed coplanar with the pseudo-tumor, either axial or sagittal, but deliberately shifted 7 to 18 mm to the side. No specific means of protection of the ribs were implemented. Post-treatment MRI follow-up was performed at D7, followed by animal necropsy and gross pathology of the liver. Results: The pseudo-tumor was clearly identified on T1w MR imaging and subsequently allowed the MRgHIFU planning. The peak temperature at the focal point ranged from 58–87 °C. Gross pathology confirmed the presence of the pseudo-tumor and the well-delineated MRgHIFU ablation at the expected locations. Conclusions: The specific design of the transducer enabled a reliable workflow. It demonstrated a good safety profile for in vivo transcostal MRgHIFU ablation of deep-liver targets, graded as challenging for standard surgery.

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Surgical approach to microwave and radiofrequency liver ablation for hepatocellular carcinoma and colorectal liver metastases less than 5 cm: a systematic review and meta-analysis

Cited by 16 publications

References 32 publications

Letter: repeat hepatic resection versus radiofrequency ablation for recurrent hepatocellular carcinoma in ideal candidates

Letter: repeat hepatic resection versus radiofrequency ablation for recurrent hepatocellular carcinoma in ideal candidates

Enhancing Patient Outcomes through Microwave Ablation in Hepatic Malignant Tumors: Insights on Recurrence Factors

In Vivo Thermal Ablation of Deep Intrahepatic Targets Using a Super-Convergent MRgHIFU Applicator and a Pseudo-Tumor Model

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