2021
DOI: 10.3390/children8060446
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Surgical Approaches to Neuroblastoma: Review of the Operative Techniques

Abstract: Neuroblastoma (NB) is the most commonly occurring soft-tissue malignancy of childhood. Surgery plays an important role in multidisciplinary treatment and its principal aim is a local control of the disease, respecting the integrity of the surrounding structures. There is no unanimous consensus on the best surgical technique, and the operative approach largely depends on the anatomical location and the extension of the mass. To have a complete overview of the different type of treatment, we made a review of the… Show more

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Cited by 10 publications
(6 citation statements)
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“…Cervical masses are very common in the pediatric population and most are benign (e.g., lipoma, fibroma, hemangioma. 5 Neuroblastoma represents a neoplastic expansion of neural crest cells in the developing sympathetic nervous system, it is approximately 97% of all neuroblastic tumors and is the third most common childhood cancer. The primary tumor originates anywhere along the sympathetic chain, usually located in the adrenal gland.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Cervical masses are very common in the pediatric population and most are benign (e.g., lipoma, fibroma, hemangioma. 5 Neuroblastoma represents a neoplastic expansion of neural crest cells in the developing sympathetic nervous system, it is approximately 97% of all neuroblastic tumors and is the third most common childhood cancer. The primary tumor originates anywhere along the sympathetic chain, usually located in the adrenal gland.…”
Section: Discussionmentioning
confidence: 99%
“…The primary tumor originates anywhere along the sympathetic chain, usually located in the adrenal gland. 5,6 The median age at diagnosis is 19 months. 7 Primary cervical neuroblastoma should be ruled out in any child less than one year of age with a persistent neck mass.…”
Section: Discussionmentioning
confidence: 99%
“…Surgery usually involves a multidisciplinary treatment strategy. 17 In contrast, instances of fetal adrenal teratoma also require aggressive surgical treatment following diagnosis but usually have a better prognosis than neuroblastoma cases and do not require chemotherapy after surgery. 18 In the present study, all newborns with adrenal neuroblastoma and teratoma underwent surgery, and all cases survived until follow-up was completed.…”
Section: Discussionmentioning
confidence: 99%
“…The standard treatment for NB consists of a coordinated sequence of chemotherapy, radiation therapy, surgical tumor resection, and combinations thereof, as well as myeloablative consolidation therapy with stem cell rescue and transplantation, 13-cis retinoic acid, and immunotherapy [ 85 , 86 ]. Surgery for low-risk NB may be sufficient support for chemotherapy with carboplatin, etoposide, cyclophosphamide, and doxorubicin [ 87 ].…”
Section: Neuroblastomas (Nbs): Standard Treatments and Challengesmentioning
confidence: 99%