Surgical ASD closure in the era of interventional procedures

Böning, Andreas; Gerken, Nicholas; Scheewe, Jens; Fischer, Gerrit; Kramer, Hans; Cremer, J.

doi:10.1055/s-2005-862090

Cited by 1 publication

(2 citation statements)

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“…Then three dose groups were set up (the original soaked solution, 1/3 of the soaked solution, 1/9 of the soaked solution) for testing. Chromosome aberration test: Chromosome aberration test was performed according to the methods described in literatures [6,7] . Sample and control preparation: Negative control: normal saline (N.S); Positive control: Mitomycin (MMC) 0.25ug/ml (-S9MIX), Cyclophosphamide (Cp) 20ug/ml (+S9MIX).Metabolism activation: The metabolic activation test in vitro was done through the induction of hepatic microsomal enzymes (S9).Peripheral blood from healthy human subjects was drawn and cultured in 1640 medium (0.5 ml peripheral blood + 4.5 ml medium).…”

Section: Genetic Toxicity and Carcinogenicity Testsmentioning

confidence: 99%

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Evaluation of the Effects of Sterilization by Irradiation on Teratogenic Toxicity of Central Vein Catheter

Yang¹,

Liu²,

Liu³

2012

AMR

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Purpose: The objective of this study was to evaluate the teraogenic toxicity of central vein catheters after irradiation sterilization and provide basis for further application of medical apparatus in future. Methods: central vein catheters were sterilized by irradiation as ISO11137 standard, afterwards, a series of tests including chromosome aberration test, micronucleus test and Ames test were performed to evaluate their teratogenic toxicity. Results: After irradiation sterilization, the samples showed no genetic toxicity (did not cause chromosomal aberrations) and no mutagenic effect, and did not increase the incidence of bone marrow cells micronucleus, demonstrating that the product material was quite stable after irradiation. Conclusions: No teratogenicity was induced in central vein catheters by the setting dose of irradiation sterilization. And therefore irradiation sterilization is a commendable method for such kind of materials, which deserves further promotion and application.

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Section: Genetic Toxicity and Carcinogenicity Testsmentioning

confidence: 99%

“…Micronucleus test was conducted according to literature [7,8] . In our study, normal saline (N.S) was taken as positive control and 2.5mg/ml cyclophosphamide was taken as negative control.…”

Section: Micronucleus Testsmentioning

confidence: 99%