Surgical Aspects of Clostridium septicum Septicemia

Pelfrey, Timothy M.

doi:10.1001/archsurg.1984.01390170044009

Cited by 34 publications

(15 citation statements)

References 32 publications

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“…It is an important pathogen not only because of its strong association with malignancy but also because of its high mortality. The mortality for infection with C septicum can be as high as 70%,2 and in one study that looked at all clostridial infections, the mortality was found to be 56% from C septicum compared to 26% from other strains 14. Other bacterial organisms that can cause pneumocephalus include E coli, E cloacae and K aerogenes 15…”

Section: Discussionmentioning

confidence: 99%

An unusual case of pneumocephalus

Bhogal

Bhatnagar²,

Manieson³

et al. 2011

Case Reports

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The authors present an unusual cause of pneumocephalus in a previously fit and well female octogenarian who presented with acute onset altered level of consciousness and generalised weakness. Radiological imaging demonstrated widespread cerebritis with pneumocephalus and gas within the superior sagittal sinus. Blood culture grew Clostridium septicum, a virulent but rare organism that can infect normal tissues. The close association between C septicum and both haematological and bowel malignancies must be considered if this organism is cultured.

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Section: Discussionmentioning

confidence: 99%

An unusual case of pneumocephalus

Bhogal

Bhatnagar²,

Manieson³

et al. 2011

Case Reports

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“…This is reflected in histological tissue samples which are shown to be deficient in number and functionality of neutrophils 17. α-Toxin contributes to septic shock by increasing capillary permeability 18. Treatment has to consider the patient's premorbid condition.…”

Section: Discussionmentioning

confidence: 99%

Non-traumatic gas gangrene presenting as left buttock and thigh pain in a patient with metastatic non-small cell lung cancer

Leaning

Dixon²,

Fisher³

2010

Case Reports

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SummaryWe report a case of Clostridium septicum myonecrosis in a patient with metastatic non-small cell lung cancer receiving palliative chemotherapy. This is a rare but important differential diagnosis in patients with known malignancy presenting with acute pain. It is critical that the diagnosis is considered and confirmed promptly due to rapid deterioration and a potentially fatal outcome in the absence of aggressive treatment. BACKGROUND

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“…Infections typically present as wound contaminations in the setting of trauma, causing gas gangrene. Spontaneous C. septicum infections are rare and have a significant association with colorectal or hematologic based malignancies ranging from 50 to 87% [3][4][5][6]. Kornbluth between 1945 and 1987 and found 162 cases.…”

Section: Discussionmentioning

confidence: 99%

Clostridium septicum Infection Associated with Necrotizing Pancreatitis, Transmural Gastric Necrosis, and Liquefaction of the Spleen

Zhou

Martindale

2007

Eur J Trauma Emerg Surg

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Spontaneous infection with Clostridium septicum (C. septicum) is rare, but when isolated it is commonly associated with malignancy. We report a case of a 47-year-old man with infected pancreatic necrosis involving greater than 80% of the pancreas, transmural gastric necrosis, and liquefaction necrosis of the spleen. Initial cultures revealed C. septicum infection. He was managed with prompt aggressive surgical debridément, resection, appropriate broad spectrum antibiotics, and early enteral nutrition.

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Surgical Aspects of Clostridium septicum Septicemia

Cited by 34 publications

References 32 publications

An unusual case of pneumocephalus

An unusual case of pneumocephalus

Non-traumatic gas gangrene presenting as left buttock and thigh pain in a patient with metastatic non-small cell lung cancer

Clostridium septicum Infection Associated with Necrotizing Pancreatitis, Transmural Gastric Necrosis, and Liquefaction of the Spleen

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