Surgical Complications After Liver Transplantation (Vascular and Biliary)

Tschuor, Christoph; Dutkowski, Philipp; Clavien, Pierre‐Alain

doi:10.1007/978-3-030-82930-8_16

Cited by 1 publication

(1 citation statement)

References 29 publications

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“…Risk scores: model for end-stage liver disease (MELD) score, 22 donor risk index (DRI), 23 Euro-transplant-DRI (ETDRI)/new theoretical ETDRI (NT-ETDRI), 24 survival outcomes following transplantation (SOFT), 25 and balance of risk (BAR) scores 26 ; 7. Post-LT outcomes: portal complications, arterial complications, biliary complications, postoperative ascites, acute cellular rejection, infectious complications, 27 postoperative morbidity according to Clavien-Dindo classification, 28 comprehensive complication index (CCI), 29 primary nonfunction (non-life-sustaining graft leading to retransplantation or death within 7 to 10 d following LT), 30 EAD according to Olthoff criteria (bilirubin ≥ 10 mg/dL and/ or international normalized ratio ≥ 1.5 on postoperative day 7, and/or transaminase levels > 2000 UI/L within the first 7 d following LT), 31 AKI according to Kidney Disease Improving Global Outcomes definition, 32 postoperative RRT, intensive care unit (ICU) stay, hospital stay, in-hospital mortality, graft survival (d), and patient survival (d).…”

Section: Data Collection and Definitionmentioning

confidence: 99%

Clinical Impact of Spontaneous Portosystemic Shunts in Liver Transplantation: A Comprehensive Assessment Through Total Shunt Area Measurement

et al. 2023

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Background. The impact of spontaneous portosystemic shunts (SPSSs) on natural history of cirrhotic patients was recently evaluated through the measurement of total shunt area (TSA), a novel tool that allows a comprehensive assessment of SPSSs extension, identifying a direct correlation of higher TSA with lower patient survival. The role of SPSSs in liver transplant (LT) is still debated: we sought to investigate the clinical impact of TSA on the development of early allograft dysfunction (EAD), acute kidney injury (AKI), postoperative complications, and graft and patient survival following LT. Methods. Preoperative imaging of 346 cirrhotic patients undergoing primary LT between 2015 and 2020 were retrospectively revised, recording the size and anatomy of each SPSS to calculate TSA. The impact of TSA and selected patient and donor characteristics on the development of EAD, AKI, and clinically relevant complications was evaluated through univariate and multivariate logistic regression, whereas their effect on graft and patient survival was investigated through Cox regression analysis. Results. A TSA exceeding 78.54 mm 2 resulted as an independent risk factor for the development of EAD (odds ratio [OR]: 2.327; P = 0.003), grade 3 AKI (OR: 2.093; P = 0.041), and clinically relevant complications (OR: 1.962; P = 0.015). Moreover, higher TSA was significantly related to early graft and patient survivals, emerging as an independent risk factor for 12-mo graft loss (hazard ratio: 3.877; P = 0.007) and patient death (hazard ratio: 2.682; P = 0.018). Conclusions. Higher TSA emerged as a significant risk factor for worse postoperative outcomes following LT, supporting the need for careful hemodynamic assessment and management of patients presenting multiple/larger shunts.

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