Introduction: Renal duodenal fistulas are a very rare connection due to chronic inflammation or infection secondary to kidney stones.
Case Report: We present a female with right perinephric abscess and reno-duodenal fistula secondary to a long-standing history of kidney stones. Treatment involved drainage of the abscess, nephrostomy tube placement, intravenous antibiotics, and open nephrectomy and duodenal repair with gastrojejunostomy.
Conclusion: In this report, we discuss management strategies which range from conservative treatment of antibiotics to open nephrectomy. In addition, we will discuss the urologic and gastroenterological post-operative complications in this patient.