Surgical decompression and radiation therapy in epidural metastasis from cervical cancer

Cormio, Gennaro; Colamaria, Antonio; Vagno, Giovanni Di; Tommasi, Antonio De; Loverro, Giuseppe; Selvaggi, Luigi

doi:10.1016/s0301-2115(99)00165-7

Cited by 12 publications

(16 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Neurologic symptoms were present in almost all patients, of which headache was the most common in our series and in most reported cases (4,5,8,(10)(11)(12)(13)(14)(15)(16) . Ikeda et al identified nausea and vomiting as the most prevalent symptoms, but even in this series, headache was common (7) .…”

Section: Discussionsupporting

confidence: 51%

“…Treatment characteristics of whole-brain irradiation are shown in Table 3. The median dose was 3750 cGy (range 3000-4000 cGy), given over a median of 11 fractions (range [10][11][12][13][14][15][16][17][18][19][20]. Two of the four patients with solitary lesions received a stereotactic boost to the tumor site.…”

Section: Resultsmentioning

confidence: 99%

“…Metastatic disease, which heralds mortality in most cases, typically occurs via local extension and lymphatic dissemination. When distant, hematogenous metastases do occur; typical sites include the liver, the lung, and the bone (3) .Brain metastasis from cervical cancer is rare, with less than 100 cases identified in a search of the English medical literature (Pubmed, no date restriction, search terms include cervical cancer, brain metastasis, CNS metastasis, cervical carcinoma) (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19) . Of these, only three manuscripts reported more than three patients (5,7,10) .…”

mentioning

confidence: 99%

See 2 more Smart Citations

Brain metastasis from cervical carcinoma

Chura

Shukla

Argenta

2007

Int J Gynecol Cancer

View full text Add to dashboard Cite

The aim of this study was to describe the features of patients with brain metastasis from cervical cancer. Twelve patients with brain metastasis from cervical cancer were identified. Information regarding symptoms, treatment, and survival was analyzed. The incidence of brain metastasis in our population was 0.77%. Median patient age at initial diagnosis of cervical cancer was 43.5 years (range 29-57 years) compared with 44.5 years (range 31-58 years) at identification of brain metastasis. Six patients had FIGO stage IB disease; three had stage IIB disease; and one each had stage IIIA, IIIB, and IVB disease. The median interval from diagnosis of cervical cancer to identification of brain metastasis was 17.5 months (range 1.1-96.1 months). All but one patient presented with neurologic symptoms. Eight patients received whole-brain irradiation and steroids, three received steroids alone, and one underwent surgery, followed by irradiation. All the patients who received whole-brain irradiation experienced improvement in their symptoms. Median survival from diagnosis of brain metastasis to death was 2.3 months (range 0.3-7.9 months). Five patients who received chemotherapy after brain irradiation had a median survival of 4.4 months compared to 0.9 months for those who received no additional treatment after brain irradiation (P= .016). Most patients with brain metastasis from cervical cancer presented with neurologic sequelae. Brain irradiation improved these symptoms. Survival after diagnosis of brain metastasis was poor; however, patients who received chemotherapy after brain irradiation appeared to have improved survival.

show abstract

Section: Discussionsupporting

confidence: 51%

Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Brain metastasis from cervical carcinoma

Chura

Shukla

Argenta

2007

Int J Gynecol Cancer

View full text Add to dashboard Cite

show abstract

“…With regard to metastases at other CNS sites, a single report describes epidural metastasis from cervical carcinoma in three patients ( 99 ) . All three underwent surgical decompression and irradiation of spinal cord tumors; tumors in all cases were grade 3 adenocarcinomas, and two had lymphovascular space invasion with multiple lymph node involvement.…”

Section: Cerebral Metastasesmentioning

confidence: 99%

“…Treatment for that patient consisted of radiosurgery to the brain, conformal radiotherapy to the lung, decompression of the spinal cord tumor, and chemotherapy. Disease persisted and progressed at all sites, and the patient died of systemic disease approximately 2 years after the first recurrence ( 99 ) .…”

Section: Cerebral Metastasesmentioning

confidence: 99%

Role of surgical resection for lung, liver, and central nervous system metastases in patients with gynecological cancer: a literature review

Tangjitgamol¹,

Levenback²,

Beller³

et al. 2004

Int J Gynecol Cancer

View full text Add to dashboard Cite

Many reports of ovarian, cervical, and uterine cancers metastatic to lung, liver, and brain have been published. A fewer number of them focused on the surgical treatment for these patients. We reviewed the published literature, regarding surgical management of metastatic disease in patients with gynecological cancer. Some prognostic factors in the patients with metastatic lesions from these three different cancers were found in common. Favorable prognostic factors for a prolonged survival were good performance status of the patients, long disease-free interval, absence of other systemic disease, and the resectability, preferably with a clear margin. These factors should be considered as the criteria for surgery. In well-selected patients, survival could be extended from the surgical procedure with minimal complications. Other types of treatment such as radiation therapy or chemotherapy could also be given in conjunction with surgery, depending on tumor type and disease status of the primary cancer, other systemic diseases, and residual metastatic lesions after surgery.

show abstract

Interdisciplinary clinical evaluation of 58 patients with lumbar-vertebral metastases from cervico-uterine cancer

Gomez

Cazares

Astudillo³

et al. 2005

Clin Transl Oncol

View full text Add to dashboard Cite

In the present series of patients, the diagnosis of metastases of the lumbar vertebrae was late, and the disease was advanced. The results obtained with radiotherapy in advanced stage disease did not improve the quality of life of patients. Metastasectomy was the therapeutic scheme in cases with intermediate stage disease and was the basis of the integrated treatment We believe that it is necessary to shorten the diagnostic time and to apply a staging system for vertebral metastases so that appropriate individualised selection of interdisciplinary treatment would be facilitated.

show abstract

Surgical decompression and radiation therapy in epidural metastasis from cervical cancer

Cited by 12 publications

References 6 publications

Brain metastasis from cervical carcinoma

Brain metastasis from cervical carcinoma

Role of surgical resection for lung, liver, and central nervous system metastases in patients with gynecological cancer: a literature review

Interdisciplinary clinical evaluation of 58 patients with lumbar-vertebral metastases from cervico-uterine cancer

Contact Info

Product

Resources

About