Surgical design and outcome of duodenum‐preserving pancreatic head resection for benign or low‐grade malignant tumors

Abstract

To apply duodenum-preserving pancreatic head resection (DPPHR) as radical procedure for benign or lowgrade malignant tumors, it needs the reconciliation of complete pancreatic head resection and preservation of the bile duct and peripancreatic vessels. Several modifications have been introduced and applied to remove these lesions, however, the techniques have not been made clear in the management of the peripancreatic vessels and the bile duct. The long-term outcomes of the DPPHR have been reported as extremely rare in comparison with pylorus preserving pancreatoduodenectomy (PPPD) in these pancreatic head tumors. The angiograms by multi-detector row CT (MD-CT) can be reconstructed more physiologically than selective angiography. The anterior arcade is predominant in 43% of 64 patients. Therefore, we modified the DPPHR to include a complete resection of the pancreatic head and the preservation of both anterior and posterior arterial arcades. The bile duct is covered by the pancreatic parenchyma in various ways. The techniques of the preservation of the bile duct are also introduced. We performed 21 DPPHRs and 19 PPPDs in the patients with benign or low-grade malignant pancreatic head tumor. There was no significant difference in operative factors. The postoperative death was one patient in PPPD, but none in DPPHR. The postoperative complications of PPPD were more often than that of DPPHR. There is no postoperative recurrence in DPPHR in the follow-up period from 2 to 216 months. Both exocrine and endocrine function and the long-term results following DPPHR were superior to those following PPPD. The DPPHR should be favored over the PPPD in benign or low-grade malignant tumors of the head of the pancreas if there is no compromise with oncologic radicality.

Duodenum-preserving total and partial pancreatic head resection for benign tumors – Systematic review and meta-analysis

“…3F). Exocrine pancreatic-function testing using a C 13 -octanoad test as well fecal chymotrypsin measurements pre-and postoperatively DPPHRt/p showed no change, contrary to a significant decrease after PD [42].…”

Duodenum‐preserving versus pylorus‐preserving pancreatic head resection for benign and premalignant lesions

“…The complication rate reported by other authors after DPPHR was 32.7% (36/110, range 0–100%) [2, 12, 13, , , , 45]. Such a striking difference in the complication rate may be due to only successful cases being reported [24, 26, 28, 32, 37, 43], to retrospective reporting [2, 12, 13, 25, 30, 31, 36, 38, 41, 45], and to the excellent results of some Japanese series [38, 45]. A 100% complication rate was reported by some authors [27, 29, 35, 39, 42].…”

“…Various alternative surgical options have been proposed during the past two decades for the management of such benign or borderline lesions of the pancreatic head . Among them, DPPHR was the more frequently used procedure, although only 132 patients are reported in the English‐language literature [2, 12, 13, ].…”

Pancreatic tumours in children: diagnosis, treatment and outcome

“…For lesions located in the pancreatic tail, laparoscopic distal pancreatectomy with preservation of the spleen seems to be the preferred surgical approach over open surgery [20]. For benign or low-grade malignant lesions located in the head of the pancreas, duodenum-preserving pancreatic head resection has been shown to have favourable outcomes in adults in terms of post-operative complications, pancreatic function and recurrence [21]. This duodenum-preserving approach has also been reported in children with pancreatic head lesions [22,23].…”