Surgical excision of non-melanoma skin cancer: no end in site?

Chouhan, Ram Pratap Singh; Patel, Rupa; Shakib, Kaveh; Mitsimponas, Konstantinos

doi:10.1016/j.bjoms.2021.05.018

Cited by 4 publications

(8 citation statements)

References 9 publications

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“…According to National Comprehensive Cancer Network Guidelines, BCCs and cSCCs in these areas are classified as high risk for recurrence independently of other cancer characteristics; therefore, more radical treatment modalities are recommended [ 15 , 20 ]. These facts align well with our results, which showed a higher re-resection rate in these areas, as they might be more complex to operate on due to the complexity of the anatomical structures and lack of excess tissue [ 16 ].…”

Section: Discussionsupporting

confidence: 91%

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Do Sex-Specific Factors Influence the Surgical Treatment of Facial Skin Cancer?

Wünscher

Spendel

Nischwitz

et al. 2023

JPM

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Facial skin cancer (FSC) is prone to incomplete excision due to the sophisticated anatomy and the aesthetic importance of the face. In this study, we sought to investigate to what extent sex-specific differences and other operation-, patient-, and cancer-specific factors influence the re-resection rate in FSC surgery, in order to provide personalized treatment strategies to patients. In this retrospective study, patients (>18 years) undergoing surgical excision of an FSC were enrolled. Each patient’s demographic data, cancer location, the surgical team, primary and secondary surgeries were analyzed. Overall, 469 patients (819 surgeries) were included. The mean age was 69 ± 15 years. No significant association between sex-specific factors (surgeon’s sex (OR: 1.09, 95% CI: 0.76–1.56) or patient’s sex (OR: 0.85, 95% CI: 0.62–1.17), surgeon–patient sex concordance and discordance) and the likelihood of secondary surgery were found. However, healing by secondary intention (OR: 4.28; 95% CI: 1.94–9.45) and cancer location showed an increased re-resection rate. In conclusion, FSC surgery is a safe method unaffected by sex-specific factors, which had no impact on the re-resection rate. However, in further analysis, the likelihood of a re-resection was influenced by other factors such as healing by secondary intention and cancer location. This knowledge might be useful to provide an algorithm for personalized treatment strategies in the future.

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Section: Discussionsupporting

confidence: 91%

“…If the BCC showed characteristics of more than one subtype according to the histopathological report, the subtype “mixed” was allocated to the cancer. Histopathological subtypes such as morpheaform clinically present as plaques with poorly defined borders, making preoperative markings challenging [ 15 , 16 ].…”

Section: Methodsmentioning

confidence: 99%

Do Sex-Specific Factors Influence the Surgical Treatment of Facial Skin Cancer?

Wünscher

Spendel

Nischwitz

et al. 2023

JPM

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“…However, temporal cutaneous malignancies, overlying the temporal fossa, are challenging for surgeons. 1,2 This is mainly due to the risk of injury to the temporal (frontal) branches of the facial nerve, with a possible loss of ability to lift the eyebrow. Furthermore, the temple’s relatively thin, soft tissue may compromise the deep-margin clearance during surgery.…”

Section: Introductionmentioning

confidence: 99%

“…The incidence of skin cancer is increasing, which is attributed to increased exposure to sunlight and an increased older population, among other factors. 1,2 In general, the management of suspected skin cancer after obtaining a history and clinical examination is primarily surgical. This includes both therapeutic excision and diagnostic biopsy.…”

Section: Introductionmentioning

confidence: 99%

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Maintaining Functionality in Temporal Skin Tumor Surgery: A Focus on Nerve Injury and Excision Margins

Al-Aswad,

Fernandez-Diaz,

Abdelrazek

et al. 2024

Plastic and Reconstructive Surgery - Global Open

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Background: Operating on temporal cutaneous tumors is challenging because of the intricate facial nerve system, particularly the frontal branches, and the possibility of brow dysfunction. Surgery for deep margin clearance is difficult because of the fragile and sensitive soft tissue in the temporal region. To address this research gap, this study assessed clearance margins, types of skin tumors, and nerve injuries in this critical anatomical position. This retrospective study assessed temporal skin cancer surgery, malignancy types, and clearance margins in patients with frontal-branch facial nerve injuries. Methods: Forty-five patients with temporal skin carcinoma biopsies were analyzed. The deep and peripheral excision margins of skin malignancies were examined. Medical records were reviewed for clinically injured frontal nerve. Results: Thirty-four patients were men (75%), and basal cell carcinoma was the most prevalent histological malignancy, followed by squamous cell carcinoma. The mean age of the patients was 77.8 years (39–107 years). Two patients experienced damage to the frontal branch nerve. Twenty-six percent of the skin malignancies had inadequate deep margin excision. Conclusions: Removing temporal skin lesions is difficult. We discovered a 26% and 4% probability of inadequate deep margin excision and frontal branch facial nerve injury, respectively. Temporal skin lesions must be removed safely by surgeons to preserve the branches of the facial nerves. Insufficiently removed tumors require multidisciplinary teamwork and patient discussions regarding the advantages and risks to improve results.

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Treatment of nasal squamous cell carcinoma with combination of surgery and photodynamic therapy

Cao,

Huang,

et al. 2023

Photodiagnosis and Photodynamic Therapy

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Surgical excision of non-melanoma skin cancer: no end in site?

Cited by 4 publications

References 9 publications

Do Sex-Specific Factors Influence the Surgical Treatment of Facial Skin Cancer?

Do Sex-Specific Factors Influence the Surgical Treatment of Facial Skin Cancer?

Maintaining Functionality in Temporal Skin Tumor Surgery: A Focus on Nerve Injury and Excision Margins

Treatment of nasal squamous cell carcinoma with combination of surgery and photodynamic therapy

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