Surgical Experience of Infratentorial Meningiomas : Clinical Series at a Single Institution during the 20-Year Period

Jung, Mi‐Hyang; Moon, Kyung‐Sub; Lee, Kyung‐Hwa; Jang, Won Young; Jung, Tae‐Young; Jung, Shin

doi:10.3340/jkns.2014.55.6.321

Cited by 7 publications

(3 citation statements)

References 26 publications

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“…15 Similarly patients with KPS scores lower than 70 had increased rates of recurrence, and KPS score has been previously described as a predictor of meningioma recurrence after resection. 2,14,31…”

Section: Skull Base Meningiomas and Recurrence Rates After Resectionmentioning

confidence: 99%

Relevance of Simpson grading system and recurrence-free survival after surgery for World Health Organization Grade I meningioma

Nanda¹,

Bir²,

Maiti³

et al. 2017

JNS

151

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OBJECTIVE The clinical significance of the Simpson system for grading the extent of meningioma resection and its role as a predictor of the recurrence of World Health Organization (WHO) Grade I meningiomas have been questioned in the past, echoing changes in meningioma surgery over the years. The authors reviewed their experience in resecting WHO Grade I meningiomas and assessed the association between extent of resection, as evaluated using the Simpson classification, and recurrence-free survival (RFS) of patients after meningioma surgery. METHODS Clinical and radiological information for patients with WHO Grade I meningiomas who had undergone resective surgery over the past 20 years was retrospectively reviewed. Simpson and Shinshu grading scales were used to evaluate the extent of resection. Statistical analysis was conducted using Kaplan-Meier curves and Cox proportional-hazards regression. RESULTS Four hundred fifty-eight patients were eligible for analysis. Overall tumor recurrence rates for Simpson resection Grades I, II, III, and IV were 5%, 22%, 31%, and 35%, respectively. After Cox regression analysis, Simpson Grade I (extensive resection) was revealed as a significant predictor of RFS (p = 0.003). Patients undergoing Simpson Grade I and II resections showed significant improvement in RFS compared with patients undergoing Grade III and IV resections (p = 0.005). Extent of resection had a significant effect on recurrence rates for both skull base (p = 0.047) and convexity (p = 0.012) meningiomas. Female sex and a Karnofsky Performance Scale score > 70 were also identified as independent predictors of RFS after resection of WHO Grade I meningioma. CONCLUSIONS In this patient cohort, a significant association was noted between extent of resection and rates of tumor recurrence. In the authors' experience the Simpson grading system maintains its relevance and prognostic value and can serve an important role for patient education. Even though complete tumor resection is the goal, surgery should be tailored to each patient according to the risks and surgical morbidity.

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Section: Skull Base Meningiomas and Recurrence Rates After Resectionmentioning

confidence: 99%

Relevance of Simpson grading system and recurrence-free survival after surgery for World Health Organization Grade I meningioma

Nanda¹,

Bir²,

Maiti³

et al. 2017

JNS

151

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“…[32][33][34] Postoperative KPS has been shown to correlate with OS; however, it is also not recorded by NCDB. 35 Additionally, NCDB does not record cause-specific survival for AM, which precludes disease-specific survival analysis in the presence of other-cause mortality as a competing risk. However, we were able to combine PSM with multivariate Cox proportional hazards regression to evaluate association between adjuvant RT and OS while controlling for other covariates.…”

Section: Neuro-oncologymentioning

confidence: 99%

Overall survival benefit associated with adjuvant radiotherapy in WHO grade II meningioma

et al. 2017

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“…Meningioma recurrence is higher among patients with lower KPS scores. [ 41 , 66 ] Finally, there is an exponential trend in the increasing incidence of meningioma with age; rates continue increasing even after 85 years of age. [ 48 , 71 ] In contrast, the WHO grade 2 and 3 meningioma rates exhibit a peak between ages 75 and 84 years, with a subsequent decrease in the incidence.…”

Section: Race Sex Functional Status and Agementioning

confidence: 99%

Meningioma recurrence: Time for an online prediction tool?

Albakr,

Baghdadi,

Karmur

et al. 2024

Surgical Neurology International

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Background: Meningioma, the most common brain tumor, traditionally considered benign, has a relatively high risk of recurrence over a patient’s lifespan. In addition, with the emergence of several clinical, radiological, and molecular variables, it is becoming evident that existing grading criteria, including Simpson’s and World Health Organization classification, may not be sufficient or accurate. As web-based tools for widespread accessibility and usage become commonplace, such as those for gene identification or other cancers, it is timely for meningioma care to take advantage of evolving new markers to help advance patient care. Methods: A scoping review of the meningioma literature was undertaken using the MEDLINE and Embase databases. We reviewed original studies and review articles from September 2022 to December 2023 that provided the most updated information on the demographic, clinical, radiographic, histopathological, molecular genetics, and management of meningiomas in the adult population. Results: Our scoping review reveals a large body of meningioma literature that has evaluated the determinants for recurrence and aggressive tumor biology, including older age, female sex, genetic abnormalities such as telomerase reverse transcriptase promoter mutation, CDKN2A deletion, subtotal resection, and higher grade. Despite a large body of evidence on meningiomas, however, we noted a lack of tools to aid the clinician in decision-making. We identified the need for an online, self-updating, and machine-learning-based dynamic model that can incorporate demographic, clinical, radiographic, histopathological, and genetic variables to predict the recurrence risk of meningiomas. Conclusion: Although a challenging endeavor, a recurrence prediction tool for meningioma would provide critical information for the meningioma patient and the clinician making decisions on long-term surveillance and management of meningiomas.

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Surgical Experience of Infratentorial Meningiomas : Clinical Series at a Single Institution during the 20-Year Period

Cited by 7 publications

References 26 publications

Relevance of Simpson grading system and recurrence-free survival after surgery for World Health Organization Grade I meningioma

Relevance of Simpson grading system and recurrence-free survival after surgery for World Health Organization Grade I meningioma

Overall survival benefit associated with adjuvant radiotherapy in WHO grade II meningioma

Meningioma recurrence: Time for an online prediction tool?

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