Surgical Versus Conservative Treatment for Endometrial Cancer in Women of Reproductive Age: Incidence of Urinary Tract Symptoms

Abstract

Endometrial cancer is the most common gynecologic malignancy. The mainstay of treatment for endometrial cancer is total hysterectomy with bilateral salpingo-oophorectomy. Radiation and chemotherapy accompanied with progestins can also play a significant role in treatment. Lower urinary tract symptoms (LUTS) following therapy for endometrial cancer are an extremely difficult and challenging condition that deteriorates patients' quality of life. Current literature remains rather scarce regarding LUTS after therapy for endometrial cancer. This review aimed to investigate the incidence of LUTS in endometrial cancer treatment.Endometrial cancer is a very commonly diagnosed malignancy of females even in women of reproductive age. It is the sixth most common malignancy worldwide with 61.880 new cases in 2019 in the United States and nearly 11,000 deaths from the disease, which primarily affects postmenopausal women (1, 2). Its incidence is increasing especially in socioeconomically developed countries including the United States where its rate reaches 19 cases in every 100,000 women (3). Similar rates are also observed in Eastern and Northern Europe. However, an extreme increase is observed in developing countries of South Africa and several countries in Asia (3).The most frequent symptom is the post-menopausal bleeding. Other, not so rare symptoms include: irregular, unpredictable, heavy or prolonged (>7 days) periods, bleeding between periods, after sex and after menopause, pelvic pain and pressure, discharge, changes in bowel habits and urination frequency (4, 5).The treatment of endometrial cancer may be surgical or conservative (6). The surgical treatment includes exploratory laparotomy, total hysterectomy with bilateral salpingooophorectomy, robotic total hysterectomy with pelvic and paraaortic lymphadenectomy, laparoscopic-assisted vaginal hysterectomy and total laparoscopic hysterectomy (7). Conservative treatment includes the use of progestins, radiation and/or chemotherapy based on staging of the disease (8). Concerning surgical treatment, the first choice is total hysterectomy with bilateral salpingo-oophorectomy.

Sleep Disorders Prior to Adjuvant Radiation Therapy for Gynecological Malignancies

“…these patients receive local or locoregional radiotherapy, either with external beam radiotherapy (EBRT), brachytherapy or both. Anticipation of a course of radiotherapy can lead to fear and nervousness about the high-tech machinery, exposure to radiation, and potential treatment-related adverse events (2,3). One potential consequence of these concerns is the occurrence of sleep disorders.…”

Development and validation of prediction model for early warning of ovarian metastasis risk of endometrial carcinoma

“…About 25% of patients are premenopausal women, and up to 5% of women under 40 years old. [ 4 , 5 ] In view of this, whether ovariectomy has become the focus of surgical controversy, and only the trauma caused by hysterectomy also has a great impact on patients’ reproductive function.…”