“…Soft tissue augmentation with fillers has become increasingly popular for restoration of facial folds,wrinkles,volume and contour.Several non-biodegradable fillers,as silicone oil, polyacrylamide hydrogel, polymethylmethacrylate(PMMA), have been introduced in order to get long lasting results 1 .The main reason for patients asking permanent fillers instead of resorbable ones,as hyaluronic acid(HA), is related to the willingness to avoid repeated injections, although it has been clearly shown in literature that the only fillers than can be reversed by the use of an antidote are the HA-based ones 1,2 .Even though some studies have indicated permanent fillers as well tolerated with desirable aesthetic results and few complications,conversely many case reports have shown numerous adverse events 3 .Erythema,edema,bruising,infection,hypersensitivity,discoloration, vascular occlusion can be detected with all type of fillers as HA, calcium hydroxyapatite(CaHA), PMMA, poly-L-lactic acid(PLLA), however a feature not often considered and underestimated related to permanent substances, is the unpleasant appearance that may be achieved after some years after implantation 4,5 .Aging process modify facial anatomy,skeleton resorption and fat pads atrophy induces progressive tissue ptosis. For the same reason,also a permanent filler injected with transitory good result, years after implantation may induce a worsening of facial appearance during the aging process,creating a drooping/bulging effect 5,6 .…”