Surgical Management and Prognostic Factors in Patients with Subungual Melanoma

Heaton, Keith M.; El‐Naggar, Adel K.; Ensign, Lisa G.; Ross, Merrick I.; Balch, Charles M.

doi:10.1097/00000658-199402000-00012

Cited by 101 publications

(99 citation statements)

References 26 publications

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“…Consequently, traditional surgical intervention for this type of malignancy has focused predominantly on amputation. 2,3,10 Nonamputative excision has been rarely advocated in the surgical literature. 1,11 Moreover, less is known regarding the presentation, histopathologic findings, and clinical course of MIS of the nail apparatus than of other forms of MIS.…”

Section: Commentmentioning

confidence: 99%

Presentation, Histopathologic Findings, and Clinical Outcomes in 7 Cases of Melanoma In Situ of the Nail Unit

High¹,

Quirey²,

Guillén³

et al. 2004

Arch Dermatol

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Section: Commentmentioning

confidence: 99%

Presentation, Histopathologic Findings, and Clinical Outcomes in 7 Cases of Melanoma In Situ of the Nail Unit

High¹,

Quirey²,

Guillén³

et al. 2004

Arch Dermatol

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“…The rates of incidence are much higher in non-Caucasian people, representing up to 23% of melanomas in Japanese [4], 17% in Hong Kong Chinese [5] and 25% in Afro-Americans. Because of its rarity, there are only a few studies focused specifically on NAM management [6,7]. Most authors include NAM in the group of cases of acral lentiginous melanoma [8,9].…”

Section: Introductionmentioning

confidence: 99%

The Prognosis of Nail Apparatus Melanoma: 20 Years of Experience from a Single Institute

Dika

Patrizi²,

Fanti³

et al. 2016

Dermatology

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Introduction and Objectives: Nail apparatus melanoma (NAM) is an uncommon tumor, especially in Caucasians. The prognosis of patients affected by NAM was analyzed and correlated with the histopathological criteria and the surgical management of the tumors. Materials and Methods: We collected data regarding NAM referred to the Skin Cancer Unit of the Dermatology Department of the University of Bologna, from 1992 to January 2012. Results: Out of 1,327 melanoma cases diagnosed between 1992 and 2012, 42 patients were affected by NAM (2.93%). All the patients were Caucasian. Two deceased patients with insufficient medical records and 1 woman with a personal history of breast cancer were excluded. Thirty-nine cases entered this study: 24 were women (67%) and 15 men (33%). The mean age at diagnosis of NAM was 57.3 years (range 29-88 years). Statistical analyses showed that prognosis was significantly correlated with the Breslow thickness (≥/<2 mm; p = 0.02), regression (p < 0.0001) and ulceration (p = 0.04). Regarding surgical management, Kaplan-Meier's test pointed out that performing functional surgery compared to disarticulation did not correlate with a better prognosis of patients (p = 0.08). Conclusions: In our experience, the surgical management (disarticulation with respect to functional surgical excision) did not influence the prognosis of NAM patients. The latter was affected by the histopathological characteristics (Breslow thickness, regression and mitoses) and location (fingers vs. foot).

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“…In 1996, Quinn et al showed no statistical difference between proximal and distal amputations [21,34] [29]. Due to the narrow margins of this approach, it is not acceptable for the wider superficial spreading melanoma and lentigo maligna [29].…”

Section: Malignant Melanomamentioning

confidence: 99%

Subungual tumors

Dooley

Kindt

Baratz

2012

HAND

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A 60-year-old man described a 15-year history of intermittent drainage from beneath the nail plate of his left long finger. The drainage began years after the subject sustained an injury in which a thorn became embedded beneath the nail. The patient had performed a number of self-debridements over the years. He had taken oral antibiotics on multiple occasions. In the 6 months prior to presentation, the drainage became more constant along with pain and erythema. On presentation, the nail plate had a central, 2-mm defect with granulomatous tissue underneath and longitudinal melanonychia. The nail plate was tender and minimal serosanginous drainage could be expressed. The remainder of the finger and nail complex appeared normal. Radiographs of the finger were normal.

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Surgical Management and Prognostic Factors in Patients with Subungual Melanoma

Cited by 101 publications

References 26 publications

Presentation, Histopathologic Findings, and Clinical Outcomes in 7 Cases of Melanoma In Situ of the Nail Unit

Presentation, Histopathologic Findings, and Clinical Outcomes in 7 Cases of Melanoma In Situ of the Nail Unit

The Prognosis of Nail Apparatus Melanoma: 20 Years of Experience from a Single Institute

Subungual tumors

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