Surgical management of a giant condyloma of Buschke-Löwenstein in a patient with Netherton syndrome using the pedicled anterolateral thigh flap — a case report

Li, Adrienne L.K.; Walsh, Scott; McKay, Douglas R.

doi:10.1016/j.bjps.2011.03.013

Cited by 23 publications

(28 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Multifarious risk factors associated with the giant condyloma acuminatum are smoking, chronic alcoholism, diabetes, local chronic inflammation and immunosuppression. Patients with immunosuppressive state like posttransplantation and a human immunodeficiency syndrome have preponderance towards high recurrence rates known as the Netherton syndrome (8). In immunosuppressed patients, involvement of the urethra and urinary bladder has also been observed.…”

Section: Discussionmentioning

confidence: 99%

Giant Condyloma Acuminatum: A Surgical Riddle

Shukla¹,

Bharti²,

Verma³

et al. 2016

Ann Colorectal Res

View full text Add to dashboard Cite

Giant condyloma acuminatum (GCA) commonly known as Buschke-Lowenstein tumor (BLT) is a rare sexually transmitted disease, which is always preceded by condyloma accuminata and linked to human papillomavirus (HPV). Most commonly affected sites are male and female genitalia, anal and perianal regions. Giant condyloma acuminatum is well-known as slow growing but locally destructive with a high rate of recurrence and increased frequency of malignant transformation. Surgical management is considered to be the best among all the options.

show abstract

Section: Discussionmentioning

confidence: 99%

Giant Condyloma Acuminatum: A Surgical Riddle

Shukla¹,

Bharti²,

Verma³

et al. 2016

Ann Colorectal Res

View full text Add to dashboard Cite

show abstract

“…Le patient consulte parfois pour douleur péri-anale, prurit, rectorragie, écoulement purulent, perte de poids et/ou la palpation d'une masse périnéale [14]. La tumeur est toujours précédée de lésions condylomateuses grisâtres ou rosées, évoluant progressivement pour prendre un aspect papillomateux, irrégulier, en chou-fleur [3, 5].…”

Section: Discussionunclassified

“…La membrane basale reste intacte ce qui preuve la bénignité de la tumeur malgré son comportement malin [6, 13, 14]. …”

Section: Discussionunclassified

See 1 more Smart Citation

La tumeur de Buschke-Lowenstein anorectale : à propos de 16 cas et revue de la littérature

Njoumi¹,

Tarchouli²,

Ratbi³

et al. 2013

Pan Afr Med J

View full text Add to dashboard Cite

La tumeur de Buschke-Lowenstein est une affection rare appartenant au groupe des carcinomes verruqueux. Elle survient le plus souvent chez des sujets pubères en pleine activité sexuelle. Une infection par human papillomavirus (HPV) 6 et 11 est volontiers associée à ces tumeurs. Elle se caractérise par la fréquence des récidives et le risque de transformation maligne. Son traitement est difficile même si l'histologie confirme la bénignité. A partir de 16 observations de TBL et d'une revue de la littérature, les auteurs soulignent les aspects épidémiologiques, cliniques, thérapeutiques et évolutifs de cette affection.

show abstract

“…Hair abnormalities are remarkably variable: classically, hair is short, brittle, spiky, sparse and slow-to-grow, but can have a normal appearance. Severe complications include human papillomaviruses infections (Folster-Holst et al, 1999;Weber et al, 2001) and squamous cell carcinoma (Hintner et al, 1980;Saghari et al, 2002;Krasagakis et al, 2003;Hatano et al, 2005;Li et al, 2011;Natsuga et al, 2011;van der Voort and Prens, 2013), which question whether NS predisposes to HPV infections or to epithelial skin cancers.…”

Section: Inhibitormentioning

confidence: 97%

Netherton syndrome: defective kallikrein inhibition in the skin leads to skin inflammation and allergy

Furio¹,

Hovnanian²

2014

Biological Chemistry

View full text Add to dashboard Cite

Netherton syndrome (NS) is an orphan genetic skin disease with a profound skin barrier defect and severe allergic manifestations. NS is caused by loss of function mutations in SPINK5 encoding lympho-epithelial Kazal-type inhibitor (LEKTI), a secreted multi-domain serine protease inhibitor expressed in stratified epithelia. Studies in mouse models and in NS patients have established that unopposed kallikrein 5 activity triggers stratum corneum detachment and activates PAR-2 signaling, leading to the autonomous production of pro-allergic and pro-inflammatory mediators. This emerging knowledge on NS pathogenesis has highlighted a central role for protease regulation in skin homeostasis but also in the complexity of the disease, and holds the promise of new specific treatments.

show abstract

Surgical management of a giant condyloma of Buschke-Löwenstein in a patient with Netherton syndrome using the pedicled anterolateral thigh flap — a case report

Cited by 23 publications

References 10 publications

Giant Condyloma Acuminatum: A Surgical Riddle

Giant Condyloma Acuminatum: A Surgical Riddle

La tumeur de Buschke-Lowenstein anorectale : à propos de 16 cas et revue de la littérature

Netherton syndrome: defective kallikrein inhibition in the skin leads to skin inflammation and allergy

Contact Info

Product

Resources

About