Surgical management of basosquamous carcinoma with perineural invasion

Petri, William H.; Zoldos, Jozef; Wilson, Therese

doi:10.1016/0278-2391(95)90292-9

Cited by 8 publications

(5 citation statements)

References 12 publications

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“…To our knowledge the surgical management of this rare but aggressive cancer has not been reported, and only two case reports have discussed the significance of perineural invasion 10, 11. The current study demonstrates that patients with perineural invasion have significantly higher rates of metastatic disease and local recurrence when compared with patients without perineural invasion.…”

Section: Discussionmentioning

confidence: 55%

“…This means that basosquamous carcinoma is a more aggressive keratinizing tumor and metastasizes at the same or greater rate than squamous cell carcinoma. This aggressive nature has been shown in two small series in which local recurrence and distant metastasis were more common than in a comparison group with squamous cell carcinoma; the 5‐year survival rate was estimated to be 17.5% 10, 11…”

Section: Discussionmentioning

confidence: 79%

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Basosquamous carcinoma

Martin

Edwards

Cawte

et al. 2000

Cancer

135

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BACKGROUND Basosquamous carcinoma is a rare malignancy, with features of both basal cell carcinoma and squamous cell carcinoma. Some authors believe that basosquamous carcinoma merely is a variant of basal cell carcinoma, whereas others have suggested that basosquamous carcinoma may behave more aggressively. To the authors' knowledge the largest published series to date, comprised of 35 cases, was reported > 20 years ago. The authors reviewed their recent experience with basosquamous carcinoma to identify prognostic factors influencing recurrence. METHODS The medical records of all patients with the diagnosis of basosquamous carcinoma treated at the University of Louisville‐affiliated hospitals between 1985–1988 were reviewed by a senior pathologist. Prognostic factors were analyzed using Cox regression analysis and the log rank test. RESULTS Thirty‐one cases of basosquamous carcinoma were identified in 28 patients. The median age at diagnosis was 68 years (range, 10–94 years). The median follow‐up was 60 months (range, 12–312 months). Seventy‐five percent of cases were located on the face, neck, and scalp. One patient had regional lymph node metastasis synchronous with the primary tumor. Patterns of recurrence were: local recurrence only (five patients), local recurrence plus regional lymph nodes (three patients), and pulmonary plus regional lymph nodes (one patient). One patient died of pulmonary metastasis. Significant factors predictive of recurrence (P < 0.01) were male gender, positive surgical resection margin, lymphatic invasion, and perineural invasion. Although tumor size was not a statistically significant factor overall (P = 0.076), the 3 patients with lymph node metastases had large tumors (measuring 2 cm, 5 cm, and 5 cm, respectively). CONCLUSIONS Basosquamous carcinoma is an aggressive epithelial neoplasm with a propensity for local recurrence and potential for distant metastatic spread. This behavior differs substantially from basal cell carcinoma. Complete resection with negative surgical margins is essential. Long term follow‐up for the detection of local recurrence and distant metastatic spread is recommended. Cancer 2000;88:1365–9. © 2000 American Cancer Society.

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Section: Discussionmentioning

confidence: 55%

Section: Discussionmentioning

confidence: 79%

Basosquamous carcinoma

Martin

Edwards

Cawte

et al. 2000

Cancer

135

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“…The third category is tumours where the cells seem to show characteristics between basal and squamous, the so‐called metatypical carcinomas. As a keratinizing tumour, the basosquamous cell carcinoma has a similar or greater rate of recurrence or metastatization than SCC: the 5‐year survival rate is estimated to be 17.5% 2,3 . In particular, the local recurrence rate of basosquamous cell carcinoma is 45.7% compared with 24.2% for BCC and 21.9% for SCC 2 .…”

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confidence: 99%

Basosquamous cell carcinoma with massive cranial osteolysis

Bianchi

Bernardi²,

Orlandi³

et al. 2003

Clinical and Experimental Dermatology

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“…19 Also the presence of positive resection margins, lymphatic invasion, and especially perineural invasion (PNI) seem to be significantly correlated to higher rates of metastatic disease and/or recurrence. 20 In a large series published by Martin et al, 19 the authors demonstrated that patients with BSC and PNI have higher rates of metastasis and local disease recurrence in comparison to patients without PNI (55% vs 5.3%). Such clinicopathological association (BSC with PNI) is also present in both patients of our study.…”

Section: Discussionmentioning

confidence: 96%

Metastatic Basosquamous Carcinoma

Bucci

Santoro²,

Pannone

et al. 2016

Int J Surg Pathol

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Basosquamous carcinoma is a rare cutaneous tumor considered by some authors as an aggressive type of basal cell carcinoma having a propensity for local recurrence and a potential risk for regional and distant metastatic spread. Herein we present 2 cases of basosquamous carcinoma of head and neck region, with metastatic spread to parotid gland (case 1) and to cervical nodes (case 2). Both patients had recurrence 2 years after initial treatment of the primary lesion (first patient: surgery; second patient: radiotherapy) and at the same time developed regional metastases. We conclude that basosquamous carcinoma must be considered as an aggressive variant of basal cell carcinoma having a great propensity to metastasize even at an early tumor stage. The clinical features, the morphologic aspects, and the treatment of this rare entity are discussed in this article.

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Surgical management of basosquamous carcinoma with perineural invasion

Cited by 8 publications

References 12 publications

Basosquamous carcinoma

Basosquamous carcinoma

Basosquamous cell carcinoma with massive cranial osteolysis

Metastatic Basosquamous Carcinoma

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