Surgical management of colorectal cancer in patients with psychiatric disorders

Hashimoto, Naoki; Isaka, Naoki; Ishizawa, Yoshiya; Mitsui, Toshihito; Sasaki, Makoto

doi:10.1007/s00595-008-3901-9

Cited by 12 publications

(20 citation statements)

References 14 publications

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“…The finding of increased mortality among antidepressant users is consistent with two previous studies comparing CRC patients with psychiatric disorders with those without psychiatric disorders [3,14]. By including CRC patients of all ages in a large population-based cohort, our results extend these previous findings.…”

Section: Other Studiessupporting

confidence: 92%

Preadmission use of antidepressants and risk of complications and death after colorectal cancer surgery: a nationwide population‐based cohort study

et al. 2019

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Aim Few studies have evaluated how preadmission use of antidepressants affects outcomes in colorectal cancer (CRC) patients after they have undergone surgery. Therefore, our aim is to examine whether preadmission use of antidepressants increased the risk of complications and death in patients who underwent CRC surgery. Method Using the Danish Colorectal Cancer Group Database we identified patients who underwent CRC surgery in Denmark from 2005 to 2012. We identified prescriptions for antidepressants redeemed within 1 year prior to surgery and categorized patients as current users (≤ 90 days), former users (91–365 days) and nonusers. All patients were followed from surgery to 30 days thereafter or to death. We calculated 30‐day rates of complications, intensive care unit (ICU) admission and mortality and compared these between users and nonusers using logistic and Cox regression adjusting for potential confounders. Results Of 27 374 patients, 8.9% were current users and 3.0% were former users. Antidepressant users were older and had more comorbidity but a similar cancer stage. Compared with nonusers, current users had a higher risk of postoperative reoperation [adjusted odds ratio (aORs) = 1.15 (95% CI 1.02–1.30)], medical complications [aORs = 1.41 (95% CI 1.25–1.60)] and increased ICU admission rate [adjusted hazard ratio (aHR) = 1.32 (95% CI 1.21–1.45)]. The 30‐day mortality was 11.4% for current users, 9.1% for former users and 6.2% for nonusers [aHR = 1.34 (95% CI 1.17–1.53) for current vs nonusers]. Conclusion Patients with preadmission use of antidepressants had a higher risk of complications and ICU admission, and higher 30‐day mortality following CRC surgery than nonusers.

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Section: Other Studiessupporting

confidence: 92%

Preadmission use of antidepressants and risk of complications and death after colorectal cancer surgery: a nationwide population‐based cohort study

et al. 2019

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“…29,36,37 Factors suggested as affecting poorer operative outcomes in those with psychiatric illness included the following: the patients' psychotic or hazardous health behaviour; interactions between antipsychotics and anaesthetics or analgesias; 37 and insufficient nutrition. 38 However, we could not assess the overall short-term mortality because our data did not include post-discharge information.…”

Section: Interpretation Of Our Findingsmentioning

confidence: 99%

Differences in cancer stage, treatment and in-hospital mortality between patients with and without schizophrenia: retrospective matched-pair cohort study

et al. 2016

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BackgroundHealthcare access and outcomes in cancer patients with schizophrenia remain unclear.AimsTo investigate the likelihood of early diagnosis and treatment in patients with schizophrenia who have cancer and their prognosis.MethodA retrospective matched-pair cohort of gastrointestinal cancer patients was identified using a national in-patient database in Japan. Multivariable ordinal/binary logistic regressions was modelled to compare cancer stage at admission, invasive treatments and 30-day in-hospital mortality between patients with schizophrenia (n = 2495) and those without psychiatric disorders (n = 9980).ResultsThe case group had a higher proportion of stage IV cancer (33.9% v. 18.1%), a lower proportion of invasive treatment (56.5% v. 70.2%, odds ratio (OR) = 0.77, 95% CI 0.69–0.85) and higher in-hospital mortality (4.2% v. 1.8%, OR = 1.35, 95% CI 1.04–1.75).ConclusionsPatients with schizophrenia who had gastrointestinal cancer had more advanced cancer, a lower likelihood of invasive treatment and higher in-hospital mortality than those without psychiatric disorders.

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“…29 A significant number of papers looked at the effect of cancer diagnosis and treatment on patients and their families. 30 Several studies have attempted to examine prevalence of psychiatric morbidity in heterogeneous samples of cancer patients in India. 31,32 The reported prevalence of diagnosable psychiatric conditions in these studies tends to range between 40% and 80%.…”

Section: Discussionmentioning

confidence: 99%

“…In rest of the study group, overall percentage of reaction to severe stress, and adjustment disorders were n=57, Hamilton Rating Scale for Depression HAM-D: Normal (<9), mild (10-13), moderate (14)(15)(16)(17) and severe (>17); Hamilton Rating Scale for Anxiety HAM-A: Normal (<11), mild (12)(13)(14)(15)(16)(17), moderate (18)(19)(20)(21)(22)(23)(24) and severe (25)(26)(27)(28)(29)(30) Thirty one subjects out of 47 cases in Group-1 had some sort of mental maladjustment either anxiety or depression, accounting to 65.95% of psychiatric morbidity whereas in Group-2 overall psychiatric illnesses was 21.42% (21 patients out of 98).…”

Section: Psychiatric Morbiditymentioning

confidence: 99%

Psychiatric morbidity in newly diagnosed carcinoma cervix and its comparison with benign condition

Raj¹,

Bhagat²

2017

Int J Reprod Contracept Obstet Gynecol

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Background: To study the psychiatric morbidity among newly diagnosed carcinoma cervix and its comparison with benign gynaecological diseases of cervix. Cervical cancer is the second most common cancer in the world and ranked first in India. It is mainly caused by sexually transmitted infection (STI) of human papilloma virus (HPV).Methods: It was an open labeled, cross-sectional and extended phase study that screened 158 patients in the age group of 18-70 years who fulfilled both inclusion and exclusion criteria and screened positive on liquid based cytology (LBC), as per guidelines of Bathesda system in Government Medical College, Patiala. 13 patients dropped out of study and finally 145 patients were enrolled. They were further divided after biopsy into two groups as per histopathological examination (HPE) i.e., Group-1, N=47 women HPE positive for cervical intraepithelial neoplasia (CIN) as Cases and Group-2, N=98 HPE negative as Control. and anxiety and severity on Hamilton Rating Scale for Depression (HAM-D) and Hamilton Rating Scale for Anxiety (HAM-A) and Hospital Anxiety Depression Scale (HADS) was used to screen psychiatric morbidity for depression.Results: Mean age of Group-1 was 38.45±11.22 SD years and Group-2 was 36.67±8.54 SD years. Psychiatric morbidity in Group-1 was 65.95% whereas Group-2 was 21.42%. P value obtained on comparing HADS score of two groups was significant (p <0.050). After active intervention there was a significant reduction in psychiatric morbidity of two groups (72% in Group-1 and 81.3% in Group-2).Conclusions: The study revealed that the breaking of bad news has a significant psycho-social impact on patients suffering from carcinoma cervix than benign group.

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Surgical management of colorectal cancer in patients with psychiatric disorders

Cited by 12 publications

References 14 publications

Preadmission use of antidepressants and risk of complications and death after colorectal cancer surgery: a nationwide population‐based cohort study

Preadmission use of antidepressants and risk of complications and death after colorectal cancer surgery: a nationwide population‐based cohort study

Differences in cancer stage, treatment and in-hospital mortality between patients with and without schizophrenia: retrospective matched-pair cohort study

Psychiatric morbidity in newly diagnosed carcinoma cervix and its comparison with benign condition

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