“…In the past, conventional systemic therapy using drugs such as dacarbazine and temozolamide resulted in 5-year overall survival (OS) of only 5-6%, 1 and surgery was a reasonable treatment option for carefully selected patients with metastatic melanoma at distant sites, achieving considerably better 5-year OS (up to 40%). 2…”
“…In the past, conventional systemic therapy using drugs such as dacarbazine and temozolamide resulted in 5-year overall survival (OS) of only 5-6%, 1 and surgery was a reasonable treatment option for carefully selected patients with metastatic melanoma at distant sites, achieving considerably better 5-year OS (up to 40%). 2…”
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